{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:43:59Z","timestamp":1758041039166,"version":"3.44.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.ajog.2009.11.034","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T00:54:54Z","timestamp":1263516894000},"page":"579.e1-579.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium"],"prefix":"10.1016","volume":"202","author":[{"given":"Raghad","family":"Samir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Asplund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Tot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyula","family":"Pekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Hellberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2009.11.034_bib1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0140-6736(83)90840-1","article-title":"Smoking as risk factor in cervical neoplasia","volume":"2","author":"Hellberg","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2009.11.034_bib2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2105\/AJPH.73.5.558","article-title":"Smoking and carcinoma in situ of the uterine cervix","volume":"73","author":"Lyon","year":"1983","journal-title":"Am J Pub Health"},{"key":"10.1016\/j.ajog.2009.11.034_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1001\/jama.1983.03340040039028","article-title":"Cigarette smoking and dysplasia and carcinoma in situ of the uterine cervix","volume":"250","author":"Trevathan","year":"1983","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2009.11.034_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1056\/NEJM198501313120516","article-title":"Cigarette smoking and neoplasia of the uterine cervix: smoke constituents in cervical mucus","volume":"312","author":"Sasson","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2009.11.034_bib5","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0002-9378(88)90093-2","article-title":"Smoking and cervical intraepithelial neoplasia: nicotine and cotinine in serum and cervical mucus in smokers and nonsmokers","volume":"158","author":"Hellberg","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2009.11.034_bib6","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/j.1360-0443.2008.02297.x","article-title":"Assessing smoking status in children, adolescents and adults: cotinine cut-points revisited","volume":"103","author":"Jarvis","year":"2008","journal-title":"Addiction"},{"key":"10.1016\/j.ajog.2009.11.034_bib7","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/jnci\/89.12.868","article-title":"Identification of tobacco-specific carcinogens in the cervical mucus of smokers and nonsmokers","volume":"89","author":"Prokopczyk","year":"1997","journal-title":"J Nat Cancer Inst"},{"key":"10.1016\/j.ajog.2009.11.034_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3835(99)00203-7","article-title":"Identification of benzo(a)pyrene metabolites in cervical mucus and DNA adducts in cervical tissues in humans by gas chromatography-mass spectrometry","volume":"146","author":"Melikian","year":"1999","journal-title":"Cancer Letters"},{"key":"10.1016\/j.ajog.2009.11.034_bib9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1074\/mcp.R500009-MCP200","article-title":"Antibody-based proteomics for human tissue profiling","volume":"4","author":"Uhlen","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.ajog.2009.11.034_bib10","first-page":"1401","article-title":"Associations between ten biological tumor markers in squamous cell cervical cancer and serum estradiol, serum progesterone and smoking","volume":"27","author":"Lindstr\u00f6m","year":"2007","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ajog.2009.11.034_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1525-1438.2007.01021.x","article-title":"LRIG and squamous epithelial cervical cancer: correlation to prognosis, sex steroid hormones, and smoking","volume":"18","author":"Lindstr\u00f6m","year":"2008","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ajog.2009.11.034_bib12","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1158\/1078-0432.CCR-05-0234","article-title":"The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer","volume":"11","author":"Holschneider","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajog.2009.11.034_bib13","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1034\/j.1600-0412.2000.0790121105.x","article-title":"The influence of cotinine on interleukin 6 expression in smokers with cervical neoplasia","volume":"79","author":"Eppel","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2009.11.034_bib14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/aje\/kwh115","article-title":"Cigarette smoking, oncogenic papillomavirus, Ki-67 antigen, and cervical intraepithelial neoplasia","volume":"159","author":"Harris","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajog.2009.11.034_bib15","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/carcin\/bgi091","article-title":"The p53 story: layers of complexity","volume":"26","author":"Braithwaite","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ajog.2009.11.034_bib16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/humu.10178","article-title":"The role of TP53 in cervical carcinogenesis","volume":"21","author":"Tommasino","year":"2003","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ajog.2009.11.034_bib17","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00428-005-1252-0","article-title":"Expression of cyclins, p53, and Ki-67 in cervical squamous cell carcinomas: overexpression of cyclin A is a poor prognostic factor in stage Ib and II disease","volume":"446","author":"Shiohara","year":"2005","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ajog.2009.11.034_bib18","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.humpath.2005.07.016","article-title":"Cell cycle and\/or proliferation markers: hat is the best method to discriminate cervical high-grade lesions?","volume":"36","author":"Lorenzato","year":"2005","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajog.2009.11.034_bib19","doi-asserted-by":"crossref","first-page":"S233","DOI":"10.1016\/j.ygyno.2007.07.064","article-title":"p16 and MIB1 improve the sensitivity and specificity of the diagnosis of high grade squamous epithelial lesions: methodological issues in a report of 447 biopsies with consensus diagnosis and HPV HCII testing","volume":"107","author":"Van Niekerk","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2009.11.034_bib20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ygyno.2008.01.008","article-title":"Cyclooxygenase-2 in cervical neoplasia: a review","volume":"109","author":"Young","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2009.11.034_bib21","first-page":"1609","article-title":"Predicting the outcome of squamous cell carcinoma of the uterine cervix using combinations of individual tumor marker expression","volume":"27","author":"Lindstr\u00f6m","year":"2007","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ajog.2009.11.034_bib22","doi-asserted-by":"crossref","first-page":"L391","DOI":"10.1152\/ajplung.00062.2005","article-title":"The aryl hydrocarbon receptor is a regulator of cigarette induction of the cyclooxygenase and prostaglandin pathways","volume":"289","author":"Martey","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajog.2009.11.034_bib23","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1158\/0008-5472.664.65.2","article-title":"Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands","volume":"65","author":"Moraitis","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2009.11.034_bib24","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/07357900802112693","article-title":"Correlation between IL-10 gene expression and HPV infection in cervical cancer: a mechanism for immune response escape","volume":"26","author":"Bermudez-Morales","year":"2008","journal-title":"Cancer Invest"},{"key":"10.1016\/j.ajog.2009.11.034_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1023305827971","article-title":"Correlates of IL-10 and IL-12 concentrations in cervical secretions","volume":"23","author":"Gravitt","year":"2003","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.ajog.2009.11.034_bib26","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.humpath.2004.08.012","article-title":"Increased secretion patterns of interleukin-10 and tumor necrosis factor-alpha in cervical squamous intraepithelial lesions","volume":"35","author":"Azar","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajog.2009.11.034_bib27","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/ijc.24117","article-title":"Diminished IFN-\u03bb and IL-10 and elevated Fox3 mRNA in the cervix are associated with CIN or 3","volume":"124","author":"Scott","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajog.2009.11.034_bib28","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1158\/1055-9965.EPI-06-0399","article-title":"Synergy between cigarette smoking and human papillomavirus type 16 in cervical cancer in situ development","volume":"15","author":"Gunnell","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293780902208X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293780902208X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:37:40Z","timestamp":1757587060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293780902208X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S000293780902208X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2009.11.034","relation":{},"ISSN":["0002-9378"],"issn-type":[{"type":"print","value":"0002-9378"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2009.11.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}