{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:30:21Z","timestamp":1762101021194,"version":"3.44.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.ajog.2009.12.016","type":"journal-article","created":{"date-parts":[[2010,2,21]],"date-time":"2010-02-21T04:28:48Z","timestamp":1266726528000},"page":"581.e1-581.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Amplification of the chromosome 3q26 region shows high negative predictive value for nonmalignant transformation of LSIL cytologic finding"],"prefix":"10.1016","volume":"202","author":[{"given":"G. Reza","family":"Jalali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Dziura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Walat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Kilpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2009.12.016_bib1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jnci\/djj009","article-title":"Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance\/low-grade squamous intraepithelial lesion triage study (ALTS)","volume":"98","author":"Kulasingam","year":"2006","journal-title":"J Natl Cancer Inst"},{"issue":"suppl","key":"10.1016\/j.ajog.2009.12.016_bib2","article-title":"Chapter 20: Issues in planning cervical cancer screening in the era of HPV vaccination","volume":"24","author":"Franco","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.ajog.2009.12.016_bib3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jnci\/93.4.293","article-title":"Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial","volume":"93","author":"Solomon","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajog.2009.12.016_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/jnci\/94.2.102","article-title":"Effects of age and human papilloma viral load on colposcopy triage: data from the randomized atypical squamous cells of undetermined significance\/low-grade squamous intraepithelial lesion triage study (ALTS)","volume":"94","author":"Sherman","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajog.2009.12.016_bib5","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/S0140-6736(04)17354-6","article-title":"Regression of low-grade squamous intra-epithelial lesions in young women","volume":"364","author":"Moscicki","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2009.12.016_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jnci\/92.5.397","article-title":"The ALTS Group: human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial","volume":"92","author":"Koutsky","year":"2000","journal-title":"J Natl Cancer Inst"},{"issue":"suppl","key":"10.1016\/j.ajog.2009.12.016_bib7","article-title":"Chapter 5: Updating the natural history of HPV and anogenital cancer","volume":"24","author":"Moscicki","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.ajog.2009.12.016_bib8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/AOG.0b013e31818f5008","article-title":"Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2","volume":"113","author":"Castle","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2009.12.016_bib9","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ctrv.2006.07.008","article-title":"The up to date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia; the Cochrane colposcopy & cervical cytopathology collaborative group (C5 group) approach","volume":"32","author":"Kyrgiou","year":"2006","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ajog.2009.12.016_bib10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ajog.2007.07.047","article-title":"2006 Consensus guidelines for the management of women with abnormal cervical cancer screening tests","volume":"197","author":"Wright","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2009.12.016_bib11","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.5858\/2004-128-1224-BIARRP","article-title":"Bethesda 2001 implementation and reporting rates: 2003 practices of participants in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology","volume":"128","author":"Davey","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.ajog.2009.12.016_bib12","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0002-9378(03)00413-7","article-title":"A randomized trial on the management of low grade squamous intraepithelial lesion cytology interpretations","volume":"188","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"suppl","key":"10.1016\/j.ajog.2009.12.016_bib13","doi-asserted-by":"crossref","first-page":"K29","DOI":"10.1016\/j.vaccine.2008.06.019","article-title":"Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries","volume":"26","author":"Cuzick","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.ajog.2009.12.016_bib14","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)63498-0","article-title":"Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia","volume":"163","author":"Heselmeyer-Haddad","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajog.2009.12.016_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ygyno.2008.01.040","article-title":"Gain of the 3q26 region in cervicovaginal liquid-based pap preparations is associated with squamous intraepithelial lesions and squamous cell carcinoma","volume":"110","author":"Caraway","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2009.12.016_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1073\/pnas.93.1.479","article-title":"Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix","volume":"93","author":"Heselmeyer","year":"1996","journal-title":"PNAS"},{"key":"10.1016\/j.ajog.2009.12.016_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1098-2264(199708)19:4<233::AID-GCC5>3.0.CO;2-Y","article-title":"Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q","volume":"19","author":"Heselmeyer","year":"1997","journal-title":"Genes Chromosom Cancer"},{"key":"10.1016\/j.ajog.2009.12.016_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/path.2070","article-title":"Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer","volume":"210","author":"Hopman","year":"2006","journal-title":"J Pathol"},{"key":"10.1016\/j.ajog.2009.12.016_bib19","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0002-9440(10)62341-3","article-title":"Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer","volume":"166","author":"Heselmeyer-Haddad","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajog.2009.12.016_bib20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.2353\/jmoldx.2007.070007","article-title":"Chromosomal biomarkers for detection of human papillomavirus associated genomic instability in epithelial cells of cervical cytology specimens","volume":"9","author":"Sokolova","year":"2007","journal-title":"J Mol Diag"},{"key":"10.1016\/j.ajog.2009.12.016_bib21","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1001\/jama.287.16.2114","article-title":"The 2001 Bethesda System: terminology for reporting results of cervical cytology","volume":"287","author":"Solomon","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2009.12.016_bib22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ygyno.2009.03.031","article-title":"Gain of 3q26: a genetic marker in low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix","volume":"114","author":"Seppo","year":"2009","journal-title":"Gynecol Oncol"},{"year":"2003","series-title":"The statistical evaluation of medical tests for classification and prediction","author":"Pepe","key":"10.1016\/j.ajog.2009.12.016_bib23"},{"key":"10.1016\/j.ajog.2009.12.016_bib24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/ijc.24010","article-title":"Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older","volume":"124","author":"Meijer","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajog.2009.12.016_bib25","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/01.AOG.0000263461.71732.40","article-title":"Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significance","volume":"109","author":"Safaeian","year":"2007","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937809022741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937809022741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:37:44Z","timestamp":1757587064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937809022741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0002937809022741"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2009.12.016","relation":{},"ISSN":["0002-9378"],"issn-type":[{"type":"print","value":"0002-9378"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amplification of the chromosome 3q26 region shows high negative predictive value for nonmalignant transformation of LSIL cytologic finding","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2009.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}