{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:01:15Z","timestamp":1791846075308,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.ajog.2010.03.017","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T04:41:03Z","timestamp":1273552863000},"page":"75.e7-75.e15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate"],"prefix":"10.1016","volume":"203","author":[{"given":"Maria","family":"Serrano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingda","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Brinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kersti K.","family":"Linask","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2010.03.017_bib1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/bdra.20461","article-title":"Maternal periconceptional smoking and alcohol consumption and risk for select congenital anomalies","volume":"82","author":"Grewal","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ajog.2010.03.017_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1242\/dmm.001438","article-title":"Folate rescues lithium-, homocysteine-, and Wnt3A-induced vertebrate cardiac anomalies","volume":"2","author":"Han","year":"2009","journal-title":"Dis Models Mech"},{"key":"10.1016\/j.ajog.2010.03.017_bib3","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/bdra.20448","article-title":"Molecular effects of lithium exposure during mouse and chick gastrulation and subsequent valve dysmorphogenesis","volume":"82","author":"Chen","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ajog.2010.03.017_bib4","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s11999-008-0171-1","article-title":"Ethanol may suppress Wnt\/beta-catenin signaling on human bone marrow stroma cells: a preliminary study","volume":"466","author":"Yeh","year":"2008","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.ajog.2010.03.017_bib5","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4161\/cc.7.24.7189","article-title":"Wnt\/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis","volume":"7","author":"Kwon","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ajog.2010.03.017_bib6","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/dvdy.20878","article-title":"Early temporal-specific responses and differential sensitivity to lithium and Wnt-3A exposure during heart development","volume":"235","author":"Manisastry","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ajog.2010.03.017_bib7","doi-asserted-by":"crossref","first-page":"9685","DOI":"10.1073\/pnas.0702859104","article-title":"Biphasic role for Wnt\/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells","volume":"104","author":"Ueno","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2010.03.017_bib8","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1070824","article-title":"Ectodermal Wnt function as a neural crest inducer","volume":"297","author":"Garcia-Castro","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ajog.2010.03.017_bib9","doi-asserted-by":"crossref","first-page":"R713","DOI":"10.1016\/S0960-9822(01)00417-1","article-title":"Heads or tails: wnts and anterior-posterior patterning","volume":"11","author":"Yamaguchi","year":"2001","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajog.2010.03.017_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J Morphol"},{"key":"10.1016\/j.ajog.2010.03.017_bib11","article-title":"Culture of avian embryos","volume":"vol 1","author":"Darnell","year":"2000"},{"key":"10.1016\/j.ajog.2010.03.017_bib12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1203\/00006450-199610000-00020","article-title":"Doppler echocardiography of normal and abnormal embryonic mouse heart","volume":"40","author":"Gui","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajog.2010.03.017_bib13","first-page":"245","article-title":"Use of Doppler echocardiography to monitor embryonic mouse heart function","volume":"135","author":"Linask","year":"2000","journal-title":"Methods Mol Bio"},{"key":"10.1016\/j.ajog.2010.03.017_bib14","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1542\/peds.104.6.e66","article-title":"Dose-dependent effect of folic acid on the prevention of orofacial clefts","volume":"104","author":"Czeizel","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2010.03.017_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.ph.49.030187.001005","article-title":"What does the power function reveal about structure and function in animals of different size?","volume":"49","author":"Heusner","year":"1987","journal-title":"Ann Rev Physiol"},{"key":"10.1016\/j.ajog.2010.03.017_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/dvdy.1131","article-title":"Sodium-calcium exchanger (NCX-1) and calcium modulation: NCX protein expression patterns and regulation of early heart development","volume":"221","author":"Linask","year":"2001","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ajog.2010.03.017_bib17","first-page":"165","article-title":"Application of plastic embedding for sectioning whole-mount immunostained early vertebrate embryos","volume":"135","author":"Linask","year":"2000","journal-title":"Method Mol Biol"},{"key":"10.1016\/j.ajog.2010.03.017_bib18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ydbio.2005.08.041","article-title":"The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary\/anterior heart field","volume":"287","author":"Verzi","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajog.2010.03.017_bib19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0736-5748(92)90016-S","article-title":"Patterns of ethanol-induced cell death in the developing nervous system of mice: neural fold states through the time of anterior neural tube closure","volume":"10","author":"Kotch","year":"1992","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.ajog.2010.03.017_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/tera.1420270211","article-title":"Some teratogenic properties of ethanol and acetaldehyde in C57BL\/6J mice: implications for the study of the fetal alcohol syndrome","volume":"27","author":"Webster","year":"1983","journal-title":"Teratology"},{"key":"10.1016\/j.ajog.2010.03.017_bib21","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai","year":"2003","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajog.2010.03.017_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1101\/gad.1279405","article-title":"Heart induction by Wnt antagonists depends on the homeodomain transcription factor hex","volume":"19","author":"Foley","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajog.2010.03.017_bib23","doi-asserted-by":"crossref","first-page":"b1673","DOI":"10.1136\/bmj.b1673","article-title":"Prevalence of severe congenital heart disease after folic acid fortification of grain products: time trend analysis in Quebec, Canada","volume":"338","author":"Ionescu-Ittu","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2010.03.017_bib24","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1111\/j.1753-4887.2004.tb00065.x","article-title":"Folate and vitamin B12 recommended intakes and status in the United States","volume":"62","author":"Bailey","year":"2004","journal-title":"Nutr Rev"},{"key":"10.1016\/j.ajog.2010.03.017_bib25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1530-0277.2000.tb04559.x","article-title":"Genetic and developmental modulation of cardiac deficits in prenatal alcohol exposure","volume":"24","author":"Cavieres","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajog.2010.03.017_bib26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.reprotox.2009.03.018","article-title":"Developmental toxicity of ethanol in chick heart in ovo and in micromass culture can be prevented by addition of vitamin C and folic acid","volume":"28","author":"Memon","year":"2009","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.ajog.2010.03.017_bib27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1101\/gad.855501","article-title":"Inhibition of Wnt activity induces heart formation from posterior mesoderm","volume":"15","author":"Marvin","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajog.2010.03.017_bib28","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1172\/JCI31731","article-title":"Wnt\/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling","volume":"117","author":"Cohen","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajog.2010.03.017_bib29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature02028","article-title":"The Wnt\/beta-catenin pathway regulates cardiac valve formation","volume":"425","author":"Hurlstone","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2010.03.017_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/bdra.20440","article-title":"Fetal alcohol syndrome (FAS) in C57BL\/6 mice detected through proteomics screening of the amniotic fluid","volume":"82","author":"Datta","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ajog.2010.03.017_bib31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/01.RES.0000141146.95728.da","article-title":"Heart valve development: endothelial cell signaling and differentiation","volume":"95","author":"Armstrong","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.ajog.2010.03.017_bib32","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1098\/rstb.2007.2130","article-title":"Valvulogenesis: the moving target","volume":"362","author":"Butcher","year":"2007","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.ajog.2010.03.017_bib33","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.RES.0000141429.13560.cb","article-title":"Lineage and morphogenetic analysis of the cardiac valves","volume":"95","author":"de Lange","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.ajog.2010.03.017_bib34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0012-1606(02)00024-6","article-title":"Hensen's node gives rise to the ventral midline of the foregut, implications for organizing head and heart development","volume":"253","author":"Kirby","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajog.2010.03.017_bib35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/GRF.0b013e31816fea3d","article-title":"Pregnancy and alcohol use: evidence and recommendations for prenatal care","volume":"51","author":"Bailey","year":"2008","journal-title":"Clin Obstet Gynecol"},{"issue":"suppl","key":"10.1016\/j.ajog.2010.03.017_bib36","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/j.placenta.2006.11.003","article-title":"Complex expression pattern of Wnt ligands and frizzled receptors in human placenta and its trophoblast subtypes","volume":"21","author":"Sonderegger","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2010.03.017_bib37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1126\/science.1173288","article-title":"Dependence of mouse embryonic stem cells on threonine catabolism","volume":"325","author":"Wang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ajog.2010.03.017_bib38","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1101\/gad.1385806","article-title":"The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes","volume":"20","author":"Sierra","year":"2006","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajog.2010.03.017_bib39","doi-asserted-by":"crossref","first-page":"8164","DOI":"10.1128\/MCB.00555-07","article-title":"Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors","volume":"27","author":"Wohrle","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajog.2010.03.017_bib40","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bbamcr.2008.08.013","article-title":"WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1","volume":"1793","author":"Liu","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajog.2010.03.017_bib41","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/dvdy.21094","article-title":"Epigenetics in development","volume":"236","author":"Kiefer","year":"2007","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ajog.2010.03.017_bib42","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.1171468","article-title":"Epigenetic temporal control of mouse Hox genes in vivo","volume":"324","author":"Soshnikova","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ajog.2010.03.017_bib43","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1523\/JNEUROSCI.5731-07.2008","article-title":"Brain chromatin remodeling: a novel mechanism of alcoholism","volume":"28","author":"Pandey","year":"2008","journal-title":"J Neurosci"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937810003157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937810003157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:35:16Z","timestamp":1757586916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937810003157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0002937810003157"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2010.03.017","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2010.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}