{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:11:40Z","timestamp":1791231100545,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.ajog.2010.06.011","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T04:49:24Z","timestamp":1281070164000},"page":"477.e1-477.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Steroid profiling in preeclamptic women: evidence for aromatase deficiency"],"prefix":"10.1016","volume":"203","author":[{"given":"Alexandre","family":"Hertig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Liere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Chabbert-Buffet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Fort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Pianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Eychenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Cambourg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Berkane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lefevre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Uzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rondeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rozenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Edith","family":"Rafestin-Oblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2010.06.011_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2010.06.011_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ncpneph0880","article-title":"How should women with pre-eclampsia be followed up?","volume":"4","author":"Hertig","year":"2008","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1016\/j.ajog.2010.06.011_bib3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajog.2010.06.011_bib4","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1172\/JCI18015","article-title":"Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?","volume":"111","author":"Luttun","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajog.2010.06.011_bib5","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/ki.2009.284","article-title":"The biology of preeclampsia","volume":"76","author":"Kanasaki","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajog.2010.06.011_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-2007-999669","article-title":"Catechol-o-methyl transferase activity in the human term placenta","volume":"5","author":"Barnea","year":"1988","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajog.2010.06.011_bib7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature06951","article-title":"Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia","volume":"453","author":"Kanasaki","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2010.06.011_bib8","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1073\/pnas.91.9.3964","article-title":"2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site","volume":"91","author":"D'Amato","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2010.06.011_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/368237a0","article-title":"The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth","volume":"368","author":"Fotsis","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2010.06.011_bib10","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2353\/ajpath.2010.090513","article-title":"Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions","volume":"176","author":"Lee","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajog.2010.06.011_bib11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0378-4347(99)00563-0","article-title":"Validation of an analytical procedure to measure trace amounts of neurosteroids in brain tissue by gas chromatography-mass spectrometry","volume":"739","author":"Liere","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1016\/j.ajog.2010.06.011_bib12","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1210\/en.2006-1678","article-title":"Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography\/mass spectrometry","volume":"148","author":"Meffre","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2010.06.011_bib13","unstructured":"Hertig A, Fort J, Lefevre G, et al. Soluble endoglin in preeclamptic women with or without HELLP syndrome. Am J Obstet Gynecol (in press)."},{"key":"10.1016\/j.ajog.2010.06.011_bib14","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.ajog.2005.08.044","article-title":"Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child","volume":"195","author":"Martin","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2010.06.011_bib15","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1373\/clinchem.2004.036715","article-title":"Maternal serum sFlt1 concentration is an early and reliable predictive marker of preeclampsia","volume":"50","author":"Hertig","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2010.06.011_bib16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejogrb.2007.09.007","article-title":"Soluble endoglin levels during normotensive and hypertensive pregnancies","volume":"140","author":"Hertig","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2010.06.011_bib17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/S1470-2045(07)70377-7","article-title":"Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence","volume":"8","author":"Xue","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ajog.2010.06.011_bib18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ije\/dyg094","article-title":"Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies","volume":"32","author":"Troisi","year":"2003","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ajog.2010.06.011_bib19","first-page":"428","article-title":"Maternal plasma prolactin levels in preeclampsia","volume":"55","author":"Ranta","year":"1980","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2010.06.011_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.HYP.0000200042.64517.19","article-title":"Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction","volume":"47","author":"Salas","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2010.06.011_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000299081","article-title":"Serum levels of unconjugated and total oestrogens and dehydroepiandrosterone, progesterone and urinary oestriol excretion in pre-eclampsia","volume":"18","author":"Rosing","year":"1984","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.ajog.2010.06.011_bib22","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1471-0528.1984.tb15079.x","article-title":"Human placental lactogen in pre-eclampsia","volume":"91","author":"Obiekwe","year":"1984","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2010.06.011_bib23","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0026-0495(97)90088-3","article-title":"Maternal and fetal modulators of lipid metabolism correlate with the development of preeclampsia","volume":"46","author":"Murai","year":"1997","journal-title":"Metabolism"},{"key":"10.1016\/j.ajog.2010.06.011_bib24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0009-8981(89)90322-7","article-title":"Metabolism of androstenedione by placental microsomes in pregnancy hypertension","volume":"181","author":"H\u00e4hnel","year":"1989","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ajog.2010.06.011_bib25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1081\/ERC-120015041","article-title":"Aromatase in primate pregnancy: a review","volume":"28","author":"Kragie","year":"2002","journal-title":"Endocr Res"},{"key":"10.1016\/j.ajog.2010.06.011_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1096\/fasebj.11.1.9034163","article-title":"Cytochromes P450 11: expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage","volume":"11","author":"Simpson","year":"1997","journal-title":"Faseb J"},{"key":"10.1016\/j.ajog.2010.06.011_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1677\/joe.0.1720031","article-title":"Retinoic acids promote the action of aromatase and 17beta-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17beta-estradiol in placental cells","volume":"172","author":"Zhu","year":"2002","journal-title":"J Endocrinol"},{"key":"10.1016\/j.ajog.2010.06.011_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jri.2009.02.005","article-title":"Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts","volume":"81","author":"Diaz","year":"2009","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.ajog.2010.06.011_bib29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jsbmb.2007.11.004","article-title":"NADPH- and iron-dependent lipid peroxidation inhibit aromatase activity in human placental microsomes","volume":"110","author":"Milczarek","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ajog.2010.06.011_bib30","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/aje\/153.6.572","article-title":"Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women","volume":"153","author":"Zhang","year":"2001","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajog.2010.06.011_bib31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0895-7061(03)00897-5","article-title":"Plasma carotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwean women","volume":"16","author":"Williams","year":"2003","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.ajog.2010.06.011_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/AOG.0b013e31817c4304","article-title":"Fractional excretion of tumor necrosis factor-alpha in women with severe preeclampsia","volume":"112","author":"Cackovic","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2010.06.011_bib33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11010-008-9739-z","article-title":"Alterations in lipid peroxidation and antioxidant status in pregnancy with preeclampsia","volume":"313","author":"Kaur","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ajog.2010.06.011_bib34","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1210\/mend.14.10.0539","article-title":"Hypoxia prevents induction of aromatase expression in human trophoblast cells in culture: potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian achaete-scute homologous protein-2)","volume":"14","author":"Jiang","year":"2000","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ajog.2010.06.011_bib35","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0022-4731(85)90282-1","article-title":"Oxygen dependence of oestrogen production by human placental microsomes and cultured choriocarcinoma cells","volume":"22","author":"Aw","year":"1985","journal-title":"J Steroid Biochem"},{"key":"10.1016\/j.ajog.2010.06.011_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/107155769400100304","article-title":"Low serum estradiol and high serum progesterone concentrations characterize hypertensive pregnancies at high altitude","volume":"1","author":"Zamudio","year":"1994","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.ajog.2010.06.011_bib37","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0002-9378(00)70235-3","article-title":"The role of estrogen in the maintenance of primate pregnancy","volume":"182","author":"Albrecht","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2010.06.011_bib38","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1067\/mob.2002.127378","article-title":"Endothelial dysfunction in uterine circulation in preeclampsia: can estrogens improve it?","volume":"187","author":"Svedas","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2010.06.011_bib39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s12020-006-0012-5","article-title":"Effects of estradiol-17beta on expression of mRNA for seven angiogenic factors and their receptors in the endometrium of ovariectomized (OVX) ewes","volume":"30","author":"Johnson","year":"2006","journal-title":"Endocrine"},{"key":"10.1016\/j.ajog.2010.06.011_bib40","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1365-2265.2007.02826.x","article-title":"Reduced maternal corticosteroid-binding globulin and cortisol levels in pre-eclampsia and gamete recipient pregnancies","volume":"66","author":"Ho","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ajog.2010.06.011_bib41","first-page":"739","article-title":"Study of estradiol on treatment of preeclampsia in rat model [in Chinese]","volume":"40","author":"Wang","year":"2005","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.ajog.2010.06.011_bib42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.reprotox.2009.11.004","article-title":"The antioxidative effect of estradiol therapy on erythrocytes in women with preeclampsia","volume":"29","author":"Djordjevic","year":"2010","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.ajog.2010.06.011_bib43","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1080\/00016340500453685","article-title":"Estrogens are potentially the only steroids with an antioxidant role in pregnancy: in vitro evidence","volume":"85","author":"Reyes","year":"2006","journal-title":"Acta Obstet Gynecol Scand"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937810007696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937810007696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:31:48Z","timestamp":1762079508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937810007696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0002937810007696"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2010.06.011","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Steroid profiling in preeclamptic women: evidence for aromatase deficiency","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2010.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}