{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:32:36Z","timestamp":1777624356381,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.ajog.2011.02.035","type":"journal-article","created":{"date-parts":[[2011,4,9]],"date-time":"2011-04-09T04:15:20Z","timestamp":1302322520000},"page":"546.e10-546.e17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep"],"prefix":"10.1016","volume":"204","author":[{"given":"Jeffrey A.","family":"Keelan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Nitsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle C.","family":"Musk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Timmins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Yaegashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Newnham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2011.02.035_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2393-6-18","article-title":"Pregnancy outcome following gestational exposure to azithromycin","volume":"6","author":"Sarkar","year":"2006","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.ajog.2011.02.035_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1701-2163(16)32350-7","article-title":"The effect of second-trimester antibiotic therapy on the rate of preterm birth","volume":"29","author":"Morency","year":"2007","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.ajog.2011.02.035_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00404-010-1646-3","article-title":"Antibiotic chemotherapy during pregnancy and lactation period: aspects for consideration","volume":"283","author":"Mylonas","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ajog.2011.02.035_bib4","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0140-6736(00)04233-1","article-title":"Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial","volume":"357","author":"Kenyon","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2011.02.035_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0095-5108(03)00101-5","article-title":"The epidemiology of preterm birth","volume":"30","author":"Iams","year":"2003","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.ajog.2011.02.035_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000262.pub3","article-title":"Antibiotics for treating bacterial vaginosis in pregnancy","author":"McDonald","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajog.2011.02.035_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/siny.2002.0121","article-title":"Infection and prematurity and the role of preventive strategies","volume":"7","author":"Romero","year":"2002","journal-title":"Semin Neonatol"},{"key":"10.1016\/j.ajog.2011.02.035_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001058.pub2","article-title":"Antibiotics for preterm rupture of membranes","volume":"8","author":"Kenyon","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajog.2011.02.035_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1517\/13543784.16.3.337","article-title":"Emerging drug therapies for preventing spontaneous preterm labor and preterm birth","volume":"16","author":"Lamont","year":"2007","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.ajog.2011.02.035_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000262.pub2","article-title":"Antibiotics for treating bacterial vaginosis in pregnancy","author":"McDonald","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajog.2011.02.035_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02766648","article-title":"Successful treatment of preterm labour by eradication of Ureaplasma urealyticum with erythromycin","volume":"253","author":"Mazor","year":"1993","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ajog.2011.02.035_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000097103","article-title":"Antibiotic treatment of intra-amniotic infection with Ureaplasma urealyticum","volume":"22","author":"Smorgick","year":"2007","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ajog.2011.02.035_bib13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.qco.0000224819.42729.2e","article-title":"Antenatal infection and inflammation: what's new?","volume":"19","author":"Maxwell","year":"2006","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.ajog.2011.02.035_bib14","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1056\/NEJM198404123101502","article-title":"Association of Ureaplasma urealyticum in the placenta with perinatal morbidity and mortality","volume":"310","author":"Kundsin","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2011.02.035_bib15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0029-7844(95)00376-2","article-title":"Ureaplasma urealyticum infection of the placenta in pregnancies that ended prematurely","volume":"87","author":"Kundsin","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.02.035_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1479-828X.1997.tb02216.x","article-title":"The role of Ureaplasma urealyticum in adverse pregnancy outcome","volume":"37","author":"Knox","year":"1997","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2011.02.035_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/00016340802572646","article-title":"Quantification of Ureaplasma urealyticum DNA in the amniotic fluid from patients in PTL and pPROM and its relation to inflammatory cytokine levels","volume":"88","author":"Jacobsson","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2011.02.035_bib18","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1471-0528.2007.01410.x","article-title":"Local inflammatory response in choriodecidua induced by Ureaplasma urealyticum","volume":"114","author":"Aaltonen","year":"2007","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2011.02.035_bib19","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"Goldenberg","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2011.02.035_bib20","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1095\/biolreprod.110.084954","article-title":"Maternal administration of erythromycin fails to eradicate intrauterine ureaplasma infection in an ovine model","volume":"83","author":"Dando","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2011.02.035_bib21","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1471-0528.2000.tb13339.x","article-title":"The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin","volume":"107","author":"Heikkinen","year":"2000","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2011.02.035_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0002-9378(16)37926-1","article-title":"The placental transfer of erythomycin","volume":"69","author":"Kiefer","year":"1955","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.02.035_bib23","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1056\/NEJM197306072882307","article-title":"Transplacental passage of erythromycin and clindamycin","volume":"288","author":"Philipson","year":"1973","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2011.02.035_bib24","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.placenta.2007.03.001","article-title":"Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes","volume":"28","author":"Aye","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2011.02.035_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1517\/17425255.2.1.51","article-title":"Active transport across the human placenta: impact on drug efficacy and toxicity","volume":"2","author":"Evseenko","year":"2006","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.ajog.2011.02.035_bib26","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1067\/mob.2003.141","article-title":"Maternal and transplacental pharmacokinetics of azithromycin","volume":"188","author":"Ramsey","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.02.035_bib27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cmpb.2010.01.007","article-title":"PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel","volume":"99","author":"Zhang","year":"2010","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.ajog.2011.02.035_bib28","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/BF01967388","article-title":"Comparative in vitro activity of azithromycin, clarithromycin, erythromycin and lomefloxacin against Mycoplasma pneumoniae, Mycoplasma hominis and Ureaplasma urealyticum","volume":"9","author":"Renaudin","year":"1990","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ajog.2011.02.035_bib29","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1177\/014860719902300502","article-title":"The ontogeny of the small intestinal epithelium","volume":"23","author":"Lebenthal","year":"1999","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.ajog.2011.02.035_bib30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1128\/AAC.00771-09","article-title":"Pharmacokinetic properties of azithromycin in pregnancy","volume":"54","author":"Salman","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajog.2011.02.035_bib31","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1439-0442.2007.00986.x","article-title":"Pharmacokinetics and mammary residual depletion of erythromycin in healthy lactating ewes","volume":"54","author":"Goudah","year":"2007","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"issue":"Suppl 2","key":"10.1016\/j.ajog.2011.02.035_bib32","first-page":"11","article-title":"Predicting antibacterial response from pharmacodynamic and pharmacokinetic profiles","volume":"29","author":"Nicolau","year":"2001","journal-title":"Infection"},{"issue":"Suppl A","key":"10.1016\/j.ajog.2011.02.035_bib33","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation\u2014a review","volume":"28","author":"Carter","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2011.02.035_bib34","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1067\/S0002-9378(03)00758-0","article-title":"Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep","volume":"189","author":"Newnham","year":"2003","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937811002250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937811002250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:42:40Z","timestamp":1757587360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937811002250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0002937811002250"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2011.02.035","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2011.02.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}