{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:47Z","timestamp":1791158447660,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.ajog.2011.05.041","type":"journal-article","created":{"date-parts":[[2011,6,18]],"date-time":"2011-06-18T21:07:32Z","timestamp":1308431252000},"page":"363.e1-363.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis"],"prefix":"10.1016","volume":"205","author":[{"given":"Maeva","family":"Wendremaire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bardou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Peyronel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Hadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sagot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lirussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2011.05.041_bib1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s10995-008-0340-6","article-title":"Prevalence of overweight and obesity among women of childbearing age: results from the 2002 National Survey of Family Growth","volume":"13","author":"Vahratian","year":"2009","journal-title":"Matern Child Health J"},{"key":"10.1016\/j.ajog.2011.05.041_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.siny.2009.09.006","article-title":"Obesity in pregnancy: prevalence and metabolic consequences","volume":"15","author":"Huda","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2011.05.041_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00404-009-1288-5","article-title":"Effect of pre-pregnancy body mass index on adverse pregnancy outcome in north of China","volume":"283","author":"Liu","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ajog.2011.05.041_bib4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1471-0528.2006.01233.x","article-title":"Poor uterine contractility in obese women","volume":"114","author":"Zhang","year":"2007","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2011.05.041_bib5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1471-0528.2010.02889.x","article-title":"Maternal obesity and labour complications following induction of labour in prolonged pregnancy","volume":"118","author":"Arrowsmith","year":"2011","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2011.05.041_bib6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1467-789X.2008.00511.x","article-title":"The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: a meta-analysis","volume":"9","author":"Heslehurst","year":"2008","journal-title":"Obes Rev"},{"key":"10.1016\/j.ajog.2011.05.041_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1933719109349780","article-title":"Maternal obesity and its relationship with spontaneous and oxytocin-induced contractility of human myometrium in vitro","volume":"17","author":"Higgins","year":"2010","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajog.2011.05.041_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.physiol.62.1.413","article-title":"Leptin","volume":"62","author":"Ahima","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ajog.2011.05.041_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2011.05.041_bib10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.physbeh.2006.05.038","article-title":"The role of leptin in leptin resistance and obesity","volume":"88","author":"Zhang","year":"2006","journal-title":"Physiol Behav"},{"key":"10.1016\/j.ajog.2011.05.041_bib11","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1210\/endo.138.10.5573","article-title":"Synthesis of leptin in human placenta","volume":"138","author":"Senaris","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2011.05.041_bib12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1365-2265.1997.2441017.x","article-title":"Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy","volume":"47","author":"Hardie","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ajog.2011.05.041_bib13","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ajog.2005.06.041","article-title":"The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia","volume":"193","author":"Hendler","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.05.041_bib14","first-page":"1020","article-title":"Expression of placental leptin and leptin receptor transcripts in early pregnancy and at term","volume":"92","author":"Henson","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.05.041_bib15","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1210\/jcem.85.5.6567","article-title":"Expression of leptin receptor in human endometrium and fluctuation during the menstrual cycle","volume":"85","author":"Kitawaki","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2011.05.041_bib16","first-page":"1505","article-title":"Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?","volume":"27","author":"Markowska","year":"2005","journal-title":"Int J Oncol"},{"key":"10.1016\/j.ajog.2011.05.041_bib17","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ajog.2006.01.106","article-title":"Inhibitory effect of leptin on human uterine contractility in vitro","volume":"195","author":"Moynihan","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.05.041_bib18","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1074\/jbc.272.10.6093","article-title":"The leptin receptor","volume":"272","author":"Tartaglia","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajog.2011.05.041_bib19","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1210\/endo.138.8.5343","article-title":"Expression and characterization of a putative high affinity human soluble leptin receptor","volume":"138","author":"Liu","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2011.05.041_bib20","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1096\/fj.06-5989fje","article-title":"Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1\/2, and p38 through c-Fos and ATF1","volume":"20","author":"Cui","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.ajog.2011.05.041_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1042\/BJ20051578","article-title":"Intracellular signaling pathways activated by leptin","volume":"393","author":"Fruhbeck","year":"2006","journal-title":"Biochem J"},{"issue":"suppl","key":"10.1016\/j.ajog.2011.05.041_bib22","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.ejogrb.2009.02.044","article-title":"Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour","volume":"144","author":"Shynlova","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2011.05.041_bib23","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1095\/biolreprod.102.013763","article-title":"A functional genomic study to identify differential gene expression in the preterm and term human myometrium","volume":"68","author":"Charpigny","year":"2003","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2011.05.041_bib24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1095\/biolreprod.105.048124","article-title":"Myometrial apoptosis: activation of the caspase cascade in the pregnant rat myometrium at midgestation","volume":"74","author":"Shynlova","year":"2006","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2011.05.041_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/1933719107309646","article-title":"Vascular and myometrial changes in the human uterus at term","volume":"15","author":"Leong","year":"2008","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajog.2011.05.041_bib26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1095\/biolreprod.107.064444","article-title":"ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis","volume":"78","author":"Lirussi","year":"2008","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2011.05.041_bib27","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1476-5381.2009.00616.x","article-title":"SAR150640, a selective beta3-adrenoceptor agonist, prevents human myometrial remodeling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis","volume":"159","author":"Lirussi","year":"2010","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ajog.2011.05.041_bib28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1677\/ERC-06-0027","article-title":"Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and down-regulating Bax via a Janus kinase 2-linked pathway","volume":"14","author":"Chen","year":"2007","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.ajog.2011.05.041_bib29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/cvr\/cvp071","article-title":"Leptin attenuates cardiac apoptosis after chronic ischaemic injury","volume":"83","author":"McGaffin","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ajog.2011.05.041_bib30","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.abb.2008.06.015","article-title":"Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway","volume":"477","author":"Perez-Perez","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.ajog.2011.05.041_bib31","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3109\/10428191003802365","article-title":"Leptin receptor expression and its association with PI3K\/AKT signaling pathway in diffuse large B-cell lymphoma","volume":"51","author":"Uddin","year":"2010","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.ajog.2011.05.041_bib32","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/en.2007-1225","article-title":"Ablation of leptin signaling disrupts the establishment, development, and maintenance of endometriosis-like lesions in a murine model","volume":"149","author":"Styer","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2011.05.041_bib33","doi-asserted-by":"crossref","first-page":"H823","DOI":"10.1152\/ajpheart.00759.2009","article-title":"Involvement of calcium-calmodulin-dependent protein kinase II in endothelin receptor expression in rat cerebral arteries","volume":"298","author":"Waldsee","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajog.2011.05.041_bib34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ygyno.2004.06.040","article-title":"Expression of leptin and leptin receptors in gestational trophoblastic diseases","volume":"95","author":"Li","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2011.05.041_bib35","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/cdd.2009.44","article-title":"Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes","volume":"16","author":"Galluzzi","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ajog.2011.05.041_bib36","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nature01388","article-title":"STAT3 signaling is required for leptin regulation of energy balance but not reproduction","volume":"421","author":"Bates","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2011.05.041_bib37","first-page":"683","article-title":"Leptin regulates the proliferation and apoptosis of human endometrial epithelial cells","volume":"22","author":"Tanaka","year":"2008","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.ajog.2011.05.041_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.domaniend.2009.06.001","article-title":"Comparison of effects of leptin and ghrelin on porcine ovarian granulosa cells","volume":"39","author":"Sirotkin","year":"2010","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.ajog.2011.05.041_bib39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1081\/PRG-200059877","article-title":"Raised leptin concentrations in feto-placental tissues from women with preeclampsia","volume":"24","author":"Singh","year":"2005","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.ajog.2011.05.041_bib40","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ajog.2006.06.021","article-title":"The transcriptome of the uterine cervix before and after spontaneous term parturition","volume":"195","author":"Hassan","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.05.041_bib41","doi-asserted-by":"crossref","first-page":"484.e1","DOI":"10.1016\/j.ajog.2007.01.021","article-title":"Why do membranes rupture at term?","volume":"196","author":"Reti","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.05.041_bib42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jcb.20521","article-title":"Leptin expression in human primary skeletal muscle cells is reduced during differentiation","volume":"96","author":"Solberg","year":"2005","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ajog.2011.05.041_bib43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1271\/bbb.70244","article-title":"Leptin promotes proliferation and inhibits differentiation in porcine skeletal myoblasts","volume":"72","author":"Yu","year":"2008","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.ajog.2011.05.041_bib44","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/stem.432","article-title":"Leptin functions peripherally to regulate differentiation of mesenchymal progenitor cells","volume":"28","author":"Scheller","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajog.2011.05.041_bib45","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jcp.21622","article-title":"Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation","volume":"218","author":"Catalano","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajog.2011.05.041_bib46","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1158\/0008-5472.CAN-04-0655","article-title":"Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin","volume":"64","author":"Yin","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2011.05.041_bib47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1095\/biolreprod.106.051391","article-title":"Leptin promotes cell proliferation and survival of trophoblastic cells","volume":"76","author":"Magarinos","year":"2007","journal-title":"Biol Reprod"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937811007265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937811007265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:42:13Z","timestamp":1757587333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937811007265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0002937811007265"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2011.05.041","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2011.05.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}