{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:29:41Z","timestamp":1791160181088,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD27861"],"award-info":[{"award-number":["HD27861"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD27869"],"award-info":[{"award-number":["HD27869"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD19897"],"award-info":[{"award-number":["HD19897"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD21434"],"award-info":[{"award-number":["HD21434"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD27905"],"award-info":[{"award-number":["HD27905"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD27917"],"award-info":[{"award-number":["HD27917"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD36801"],"award-info":[{"award-number":["HD36801"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD27889"],"award-info":[{"award-number":["HD27889"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD21414"],"award-info":[{"award-number":["HD21414"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD27883"],"award-info":[{"award-number":["HD27883"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD27860"],"award-info":[{"award-number":["HD27860"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD27915"],"award-info":[{"award-number":["HD27915"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.ajog.2011.08.028","type":"journal-article","created":{"date-parts":[[2011,9,10]],"date-time":"2011-09-10T02:26:03Z","timestamp":1315621563000},"page":"145.e1-145.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["The antibiotic treatment of PPROM study: systemic maternal and fetal markers and perinatal outcomes"],"prefix":"10.1016","volume":"206","author":[{"given":"Brian M.","family":"Mercer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis T.","family":"Crouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menachem","family":"Miodovnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delicia C.","family":"Mapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Meis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell P.","family":"Dombrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2011.08.028_bib1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/01.AOG.0000263888.69178.1f","article-title":"ACOG practice bulletin no. 80: premature rupture of membranes; clinical management guidelines for obstetrician-gynecologists","volume":"109","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.08.028_bib2","first-page":"178","article-title":"Preterm premature rupture of the membranes","volume":"101","author":"Mercer","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.08.028_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cyto.2008.06.009","article-title":"Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection","volume":"44","author":"Chow","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.ajog.2011.08.028_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jri.2008.08.006","article-title":"Mid-pregnancy circulating cytokine levels, histologic chorioamnionitis and spontaneous preterm birth","volume":"79","author":"Gargano","year":"2008","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.ajog.2011.08.028_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0029-7844(97)00602-9","article-title":"Maternal serum interleukin-6 concentration as a marker for impending preterm delivery","volume":"91","author":"Murtha","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.08.028_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0029-7844(97)00294-9","article-title":"Maternal serum interleukin-6 during pregnancy and during term and preterm labor","volume":"90","author":"Greig","year":"1997","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.08.028_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/s-2007-994172","article-title":"Fetal but not maternal serum cytokine levels correlate with histologic acute placental inflammation","volume":"14","author":"Salafia","year":"1997","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajog.2011.08.028_bib8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000291862","article-title":"Value of maternal interleukin 6 level for determination of histologic chorioamnionitis in preterm delivery","volume":"43","author":"Maeda","year":"1997","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.ajog.2011.08.028_bib9","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0002-9378(98)70272-8","article-title":"The fetal inflammatory response syndrome","volume":"179","author":"Gomez","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.08.028_bib10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/14767050701227877","article-title":"Maternal plasma interleukin-6, interleukin-1beta and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery","volume":"20","author":"Skrablin","year":"2007","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2011.08.028_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/14767050500072888","article-title":"Intercellular adhesion molecule-1 concentration, in utero, decreases after antibiotic treatment","volume":"17","author":"Hadar","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2011.08.028_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0020-7292(02)00016-4","article-title":"Interleukin-6 and interleukin-1 receptor antagonist in amniotic fluid and cord blood in patients with pre-term, premature rupture of the membranes","volume":"77","author":"Fukuda","year":"2002","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.ajog.2011.08.028_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-2001-18694","article-title":"Detection of interleukin-6 in maternal plasma predicts neonatal and infectious complications in preterm premature rupture of membranes","volume":"18","author":"Lewis","year":"2001","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajog.2011.08.028_bib14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1034\/j.1600-0412.2000.079008667.x","article-title":"Predictive value of serum interleukin-6 and -8 levels in preterm labor or rupture of the membranes","volume":"79","author":"von Minckwitz","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2011.08.028_bib15","first-page":"774","article-title":"Clinical application of maternal serum cytokine determination in premature rupture of membranes\u2013interleukin-6, an early predictor of neonatal infection?","volume":"78","author":"Pfeiffer","year":"1999","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2011.08.028_bib16","first-page":"303","article-title":"Relationship of IL-6, IL-8, TNF and sICAM-1 levels to PROM, pPROM, and the risk of early-onset neonatal sepsis","volume":"29","author":"Veleminsky","year":"2008","journal-title":"Neuro Endocrinol Lett"},{"key":"10.1016\/j.ajog.2011.08.028_bib17","first-page":"37","article-title":"Cord blood cytokine levels in neonates born to mothers with prolonged premature rupture of membranes and its relationship with morbidity and mortality","volume":"19","author":"Satar","year":"2008","journal-title":"Eur Cytokine Netw"},{"key":"10.1016\/j.ajog.2011.08.028_bib18","first-page":"224","article-title":"Comparison of umbilical cord interleukin-6 in preterm infants with premature rupture of membranes and intact membranes","volume":"29","author":"Gharehbaghi","year":"2008","journal-title":"Saudi Med J"},{"key":"10.1016\/j.ajog.2011.08.028_bib19","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.ajog.2004.06.086","article-title":"Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity","volume":"191","author":"Goepfert","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.08.028_bib20","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/jama.1997.03550120049032","article-title":"Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes: a randomized controlled trial","volume":"278","author":"Mercer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2011.08.028_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0002-9378(89)90409-2","article-title":"Infection and labor, V: prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes","volume":"161","author":"Romero","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2011.08.028_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0891-5520(05)70347-0","article-title":"Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection","volume":"11","author":"Gomez","year":"1993","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.ajog.2011.08.028_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0095-5108(18)30286-0","article-title":"Premature labor and intra-amniotic infection: clinical aspects and role of cytokines in diagnosis and pathophysiology","volume":"22","author":"Gomez","year":"1995","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.ajog.2011.08.028_bib24","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s100249900161","article-title":"Fetal membrane histology in preterm premature rupture of membranes: comparison to controls, and between antibiotic and placebo treatment","volume":"2","author":"Bendon","year":"1999","journal-title":"Pediatr Dev Pathol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937811011495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937811011495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:44:20Z","timestamp":1757587460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937811011495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0002937811011495"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2011.08.028","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antibiotic treatment of PPROM study: systemic maternal and fetal markers and perinatal outcomes","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2011.08.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}