{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:43:30Z","timestamp":1769201010372,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ajog.2012.09.024","type":"journal-article","created":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T14:19:06Z","timestamp":1348841946000},"page":"497.e1-497.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Copeptin: a marker for stress reaction in fetuses with intrauterine growth restriction"],"prefix":"10.1016","volume":"207","author":[{"given":"Tilo","family":"Burkhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Schwabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils G.","family":"Morgenthaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Natalucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Wellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2012.09.024_bib1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.clp.2004.06.006","article-title":"Diagnosis and management of intrauterine growth restriction","volume":"31","author":"Harkness","year":"2004","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.ajog.2012.09.024_bib2","first-page":"490","article-title":"Intrauterine growth restriction","volume":"99","author":"Resnik","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.09.024_bib3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ajog.2010.08.055","article-title":"Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management","volume":"204","author":"Figueras","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.09.024_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0378-3782(92)90062-L","article-title":"Fetal biochemistry in growth retardation","volume":"29","author":"Soothill","year":"1992","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ajog.2012.09.024_bib5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","article-title":"Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin","volume":"52","author":"Morgenthaler","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2012.09.024_bib6","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1373\/clinchem.2005.065581","article-title":"Immunoluminometric assay for measurement of the C-terminal endothelin-1 precursor fragment in human plasma","volume":"52","author":"Papassotiriou","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2012.09.024_bib7","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1373\/clinchem.2005.051110","article-title":"Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay","volume":"51","author":"Morgenthaler","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2012.09.024_bib8","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/cc3015","article-title":"Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study","volume":"9","author":"Morgenthaler","year":"2005","journal-title":"Crit Care"},{"key":"10.1016\/j.ajog.2012.09.024_bib9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.placenta.2008.11.005","article-title":"Decreased umbilical artery compliance and IGF-I plasma levels in infants with intrauterine growth restriction\u2013implications for fetal programming of hypertension","volume":"30","author":"Burkhardt","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2012.09.024_bib10","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1210\/jc.2010-1331","article-title":"High copeptin concentrations in umbilical cord blood after vaginal delivery and birth acidosis","volume":"95","author":"Wellmann","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2012.09.024_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9378(85)90298-4","article-title":"Estimation of fetal weight with the use of head, body, and femur measurements\u2013a prospective study","volume":"151","author":"Hadlock","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.09.024_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1469-0705.1997.10020112.x","article-title":"Reference resistance indices of the umbilical, fetal middle cerebral and uterine arteries at 24-42 weeks of gestation","volume":"10","author":"Kurmanavicius","year":"1997","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.09.024_bib13","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1055\/s-2006-924458","article-title":"[Analysis of the neonatal collective in the Federal Republic of Germany, 12th report: presentation of detailed percentiles for the body measurement of newborns, in German]","volume":"66","author":"Voigt","year":"2006","journal-title":"Geburtsh Frauenheilk"},{"key":"10.1016\/j.ajog.2012.09.024_bib14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1373\/clinchem.2003.021204","article-title":"Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma","volume":"50","author":"Morgenthaler","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2012.09.024_bib15","doi-asserted-by":"crossref","first-page":"E982","DOI":"10.1210\/jc.2010-2858","article-title":"Plasma copeptin in preterm infants: a highly sensitive marker of fetal and neonatal stress","volume":"96","author":"Benzing","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2012.09.024_bib16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2431-11-38","article-title":"Copeptin concentration in cord blood in infants with early-onset sepsis, chorioamnionitis and perinatal asphyxia","volume":"11","author":"Schlapbach","year":"2011","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.ajog.2012.09.024_bib17","first-page":"341","article-title":"Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level","volume":"29","author":"Katan","year":"2008","journal-title":"Neuro Endocrinol Lett"},{"key":"10.1016\/j.ajog.2012.09.024_bib18","doi-asserted-by":"crossref","first-page":"e29562","DOI":"10.1371\/journal.pone.0029562","article-title":"Effects of cord serum insulin, IGF-II, IGFBP-2, IL-6 and cortisol concentrations on human birth weight and length: pilot study","volume":"6","author":"Smerieri","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ajog.2012.09.024_bib19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1447-0756.2007.00493.x","article-title":"Cord blood cortisol level is lower in growth-restricted newborns","volume":"33","author":"Strinic","year":"2007","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.ajog.2012.09.024_bib20","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1530\/EJE-07-0286","article-title":"Impact of fetal growth restriction on body composition and hormonal status at birth in infants of small and appropriate weight for gestational age","volume":"157","author":"Verkauskiene","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ajog.2012.09.024_bib21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1203\/PDR.0b013e318191fb44","article-title":"Blunted stress response in small for gestational age neonates","volume":"65","author":"Sch\u00e4ffer","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajog.2012.09.024_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.tem.2008.03.003","article-title":"IGF signaling defects as causes of growth failure and IUGR","volume":"19","author":"Klammt","year":"2008","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ajog.2012.09.024_bib23","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1055\/s-0029-1231026","article-title":"Changes in GH\/IGF-1 axis in intrauterine growth retardation: consequences of fetal programming?","volume":"41","author":"Setia","year":"2009","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.ajog.2012.09.024_bib24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000242126","article-title":"The effects of acute and chronic perinatal stress on plasma vasopressin concentration and renin activity at birth","volume":"47","author":"Pohjavuori","year":"1985","journal-title":"Biol Neonate"},{"key":"10.1016\/j.ajog.2012.09.024_bib25","first-page":"992","article-title":"Fetal endothelin levels and placental vascular endothelin receptors in intrauterine growth retardation","volume":"82","author":"McQeen","year":"1993","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.09.024_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00016349409013387","article-title":"Endothelin-1,2 levels in umbilical vein serum of intra-uterine growth retarded fetuses as detected by cordocentesis","volume":"73","author":"Schiff","year":"1994","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2012.09.024_bib27","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0002-9378(96)70613-0","article-title":"Elevated endothelin levels are associated with increased placental resistance","volume":"174","author":"Harvey-Wilkes","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.09.024_bib28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1515\/JPM.2003.008","article-title":"Maternal and fetal plasma endothelin levels in intrauterine growth restriction: relation to umbilical artery Doppler flow velocimetry","volume":"31","author":"Erdem","year":"2003","journal-title":"J Perinat Med"},{"key":"10.1016\/j.ajog.2012.09.024_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0020-7292(03)00332-1","article-title":"Endothelin 1 and leptin in the pathophysiology of intrauterine growth restriction","volume":"84","author":"Arslan","year":"2004","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajog.2012.09.024_bib30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12098-009-0079-0","article-title":"Endothelin-1 and leptin as markers of intrauterine growth restriction","volume":"76","author":"Nezar","year":"2009","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.ajog.2012.09.024_bib31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/14767050701412263","article-title":"Maternal and umbilical venous adrenomedullin and nitric oxide levels in intrauterine growth restriction","volume":"20","author":"Akturk","year":"2007","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2012.09.024_bib32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1067\/mob.2000.103944","article-title":"Adrenomedullin is increased in the fetoplacental circulation in intrauterine growth restriction with abnormal umbilical artery waveforms","volume":"182","author":"Di Iorio","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.09.024_bib33","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1471-0528.1992.tb14418.x","article-title":"Maternal and fetal atrial natriuretic peptide levels at delivery from normal and growth retarded pregnancies","volume":"99","author":"Kingdom","year":"1992","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2012.09.024_bib34","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1203\/01.PDR.0000061564.86797.78","article-title":"Cardiac hypertrophy and altered hemodynamic adaptation in growth-restricted preterm infants","volume":"53","author":"Leip\u00e4l\u00e4","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajog.2012.09.024_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tem.2007.11.001","article-title":"Copeptin: clinical use of a new biomarker","volume":"19","author":"Morgenthaler","year":"2008","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ajog.2012.09.024_bib36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000292452","article-title":"Brain natriuretic peptide and atrial natriuretic peptide levels in normal pregnancy and preeclampsia","volume":"38","author":"uruhashi","year":"1994","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.ajog.2012.09.024_bib37","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000330411","article-title":"Plasma C-terminal pro-endothelin-1 and the natriuretic pro-peptides NT-proBNP and MR-proANP in very preterm infants with patent ductus arteriosus","volume":"101","author":"Letzner","year":"2012","journal-title":"Neonatology"},{"key":"10.1016\/j.ajog.2012.09.024_bib38","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0006-3223(02)01569-X","article-title":"Children, stress, and sensitization: an integration of basic and clinical research on emotion?","volume":"52","author":"Pine","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.ajog.2012.09.024_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N Engl J Med"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937812010654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937812010654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:45:13Z","timestamp":1757587513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937812010654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0002937812010654"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2012.09.024","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Copeptin: a marker for stress reaction in fetuses with intrauterine growth restriction","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2012.09.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}