{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:25:45Z","timestamp":1791077145679,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ajog.2012.10.007","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T15:01:05Z","timestamp":1349708465000},"page":"514.e1-514.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model"],"prefix":"10.1016","volume":"207","author":[{"given":"Paul","family":"Berveiller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Vinot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Broutin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Deroussent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atmane","family":"Seck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Camps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Paci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Tr\u00e9luyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2012.10.007_bib1","first-page":"1","article-title":"Death in the United States, 2007","author":"Minino","year":"2009","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.ajog.2012.10.007_bib2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1200\/JCO.2009.23.2801","article-title":"Cancer during pregnancy: an analysis of 215 patients emphasizing the obstetrical and the neonatal outcomes","volume":"28","author":"Van Calsteren","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajog.2012.10.007_bib3","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1016\/j.ejca.2010.09.010","article-title":"Breast cancer in pregnancy: recommendations of an international consensus meeting","volume":"46","author":"Amant","year":"2010","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ajog.2012.10.007_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/annonc\/mdm460","article-title":"Emerging therapeutic options for breast cancer chemotherapy during pregnancy","volume":"19","author":"Mir","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ajog.2012.10.007_bib5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/annonc\/mdh009","article-title":"Anthracyclines during pregnancy: embryo-fetal outcome in 160 patients","volume":"15","author":"Germann","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ajog.2012.10.007_bib6","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1093\/annonc\/mdn553","article-title":"Chemotherapy for breast cancer during pregnancy: is epirubicin safe?","volume":"19","author":"Mir","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ajog.2012.10.007_bib7","first-page":"595","article-title":"Transplacental passage of doxorubicin","volume":"18","author":"Grohard","year":"1989","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"10.1016\/j.ajog.2012.10.007_bib8","first-page":"63","article-title":"Transplacental passage of epirubicin","volume":"24","author":"Gaillard","year":"1995","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"10.1016\/j.ajog.2012.10.007_bib9","first-page":"1456","article-title":"Transplacental transfer of paclitaxel, docetaxel, carboplatin, and trastuzumab in a baboon model","volume":"20","author":"Van Calsteren","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ajog.2012.10.007_bib10","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1016\/S0264-410X(03)00334-7","article-title":"Placental transport of immunoglobulin G","volume":"21","author":"Simister","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.ajog.2012.10.007_bib11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/annonc\/mdp517","article-title":"Taxanes for breast cancer during pregnancy: a systematic review","volume":"21","author":"Mir","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ajog.2012.10.007_bib12","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1124\/dmd.32.6.666","article-title":"Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs","volume":"32","author":"Vaclavikova","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.ajog.2012.10.007_bib13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000341820","article-title":"Taxanes during pregnancy: probably safe, but still to be optimized","volume":"83","author":"Berveiller","year":"2012","journal-title":"Oncology"},{"key":"10.1016\/j.ajog.2012.10.007_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1055\/s-2006-951301","article-title":"Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-alpha-acetylmethadol, and paclitaxel","volume":"23","author":"Nekhayeva","year":"2006","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajog.2012.10.007_bib15","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.bcp.2005.03.030","article-title":"Role of P-glycoprotein in transplacental transfer of methadone","volume":"69","author":"Nanovskaya","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajog.2012.10.007_bib16","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/0002-9378(72)90909-X","article-title":"Transfer across the perfused human placenta of antipyrine, sodium and leucine","volume":"114","author":"Schneider","year":"1972","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.10.007_bib17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2165\/00003088-199427040-00002","article-title":"Clinical pharmacokinetics of paclitaxel","volume":"27","author":"Sonnichsen","year":"1994","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.ajog.2012.10.007_bib18","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1158\/1078-0432.CCR-0842-03","article-title":"Comparative pharmacokinetics of weekly and every-three-weeks docetaxel","volume":"10","author":"Baker","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajog.2012.10.007_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejogrb.2009.08.007","article-title":"Contribution and limit of the model of perfused cotyledon to the study of placental transfer of drugs; example of a protease inhibitor of HIV: nelfinavir","volume":"147","author":"Gavard","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2012.10.007_bib20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.reprotox.2010.01.006","article-title":"Quality assessment of a placental perfusion protocol","volume":"30","author":"Mathiesen","year":"2010","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.ajog.2012.10.007_bib21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0143-4004(03)00170-X","article-title":"Basal membrane localization of MRP1 in human placental trophoblast","volume":"24","author":"Nagashige","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2012.10.007_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tips.2004.06.002","article-title":"Importance of P-glycoprotein at blood-tissue barriers","volume":"25","author":"Fromm","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.ajog.2012.10.007_bib23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.placenta.2004.05.013","article-title":"P-glycoprotein expression of the human placenta during pregnancy","volume":"26","author":"Gil","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2012.10.007_bib24","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1073\/pnas.97.7.3473","article-title":"Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo","volume":"97","author":"Hoffmeyer","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2012.10.007_bib25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1067\/mcp.2002.122055","article-title":"Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects","volume":"71","author":"Nakamura","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.ajog.2012.10.007_bib26","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.ejca.2004.01.024","article-title":"Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein","volume":"40","author":"Kemper","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ajog.2012.10.007_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2165\/00003088-199936020-00002","article-title":"Clinical pharmacokinetics of docetaxel","volume":"36","author":"Clarke","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.ajog.2012.10.007_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2165\/00003088-199528030-00005","article-title":"Placental transfer of drugs administered to the mother","volume":"28","author":"Pacifici","year":"1995","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.ajog.2012.10.007_bib29","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2165\/00003088-200443080-00001","article-title":"Drug transfer and metabolism by the human placenta","volume":"43","author":"Syme","year":"2004","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.ajog.2012.10.007_bib30","doi-asserted-by":"crossref","first-page":"815","DOI":"10.4161\/cbt.4.8.1867","article-title":"Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel","volume":"4","author":"Smith","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.ajog.2012.10.007_bib31","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1158\/1078-0432.CCR-12-0761","article-title":"Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel","volume":"18","author":"De Graan","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajog.2012.10.007_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-pharmtox-010611-134529","article-title":"Drug transporters in drug efficacy and toxicity","volume":"52","author":"DeGorter","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.ajog.2012.10.007_bib33","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1067\/mob.2001.113319","article-title":"Maternal-fetal transfer of saquinavir studied in the ex vivo placental perfusion model","volume":"185","author":"Forestier","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2012.10.007_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/clpt.2011.66","article-title":"The human placental perfusion model: a systematic review and development of a model to predict in vivo transfer of therapeutic drugs","volume":"90","author":"Hutson","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.ajog.2012.10.007_bib35","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2165\/00003088-200544100-00001","article-title":"Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach","volume":"44","author":"Anderson","year":"2005","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.ajog.2012.10.007_bib36","first-page":"386","article-title":"Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation","volume":"54","author":"Cresteil","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2012.10.007_bib37","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3816\/CBC.2006.n.049","article-title":"Effect of pregnancy on the pharmacokinetics of paclitaxel: a case report","volume":"7","author":"Lycette","year":"2006","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.ajog.2012.10.007_bib38","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3109\/00016349.2010.512070","article-title":"Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study","volume":"89","author":"Van Calsteren","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2012.10.007_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ctrv.2009.10.006","article-title":"Overall survival benefit for weekly vs three-weekly taxanes regimens in advanced breast cancer: a meta-analysis","volume":"36","author":"Mauri","year":"2010","journal-title":"Cancer Treat Rev"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937812010794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937812010794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:45:44Z","timestamp":1757587544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937812010794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0002937812010794"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2012.10.007","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2012.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}