{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:46:15Z","timestamp":1776689175715,"version":"3.51.2"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.ajog.2013.02.012","type":"journal-article","created":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T09:45:16Z","timestamp":1361699116000},"page":"492.e1-492.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers"],"prefix":"10.1016","volume":"208","author":[{"given":"Laura L.","family":"Jelliffe-Pawlowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Currier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Baer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh M.","family":"O'Brodovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey B.","family":"Gould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2013.02.012_bib1","first-page":"2916","article-title":"Corticotrophin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells","volume":"83","author":"Smith","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2013.02.012_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-2001-13909","article-title":"On the role of human chorionic gonadotropin (hCG) in the embryo-endometrial microenvironment: implications for differentiation and implantation","volume":"19","author":"Licht","year":"2001","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.ajog.2013.02.012_bib3","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"Goldenberg","year":"2000","journal-title":"N Engl J Med"},{"issue":"suppl A","key":"10.1016\/j.ajog.2013.02.012_bib4","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1016\/j.placenta.2005.10.012","article-title":"Modulation of PAPP-A expression by PPARgamma in human first trimester trophoblast","volume":"27","author":"Handschuh","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2013.02.012_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1530\/rep.1.01076","article-title":"TGF-beta superfamily expression and actions in the endometrium and placenta","volume":"132","author":"Jones","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.ajog.2013.02.012_bib6","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3181\/0612-MR-291","article-title":"Physiology of alpha-fetoprotein as a biomarker for perinatal distress: relevance to adverse pregnancy outcome","volume":"232","author":"Mizejewski","year":"2007","journal-title":"Exp Biol Med (Maywood )"},{"key":"10.1016\/j.ajog.2013.02.012_bib7","first-page":"101","article-title":"Defective implantation and placentation: laying the blueprint for pregnancy complications","volume":"14","author":"Norwitz","year":"2007","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ajog.2013.02.012_bib8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJMra061360","article-title":"Parturition","volume":"356","author":"Smith","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2013.02.012_bib9","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.2174\/092986708786848677","article-title":"PPARgamma and early human placental development","volume":"15","author":"Fournier","year":"2008","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.ajog.2013.02.012_bib10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.placenta.2009.04.007","article-title":"Placental blood flow and the risk of preterm delivery","volume":"30","author":"Misra","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2013.02.012_bib11","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1210\/jc.2008-2257","article-title":"Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor","volume":"94","author":"Smith","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2013.02.012_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/pd.2396","article-title":"Increased nuchal translucency in euploid fetuses: what should we be telling the parents?","volume":"30","author":"Bilardo","year":"2010","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2013.02.012_bib13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1210\/er.2010-0001","article-title":"Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit","volume":"32","author":"Ishimoto","year":"2011","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ajog.2013.02.012_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.placenta.2011.01.018","article-title":"Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin-A","volume":"32","author":"Fitzgerald","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2013.02.012_bib15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1471-0528.2011.03266.x","article-title":"Dysregulated biomarkers induce distinct pathways in preterm birth","volume":"119","author":"Brou","year":"2012","journal-title":"BJOG"},{"issue":"suppl","key":"10.1016\/j.ajog.2013.02.012_bib16","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.placenta.2011.11.007","article-title":"Review: human trophoblast fusion and differentiation: lessons from trisomy 21 placenta","volume":"33","author":"Pidoux","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2013.02.012_bib17","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.ajog.2004.06.052","article-title":"First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial)","volume":"191","author":"Dugoff","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib18","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.ajog.2004.05.068","article-title":"Association of extreme first-trimester free human chorionic gonadotropin-beta, pregnancy-associated plasma protein A, and nuchal translucency with intrauterine growth restriction and other adverse pregnancy outcomes","volume":"191","author":"Krantz","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib19","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/ije\/dyl154","article-title":"Maternal and biochemical predictors of spontaneous preterm birth among nulliparous women: a systematic analysis in relation to the degree of prematurity","volume":"35","author":"Smith","year":"2006","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ajog.2013.02.012_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.AOG.0000191302.79560.d8","article-title":"Pregnancy-associated plasma protein A and alpha-fetoprotein and prediction of adverse perinatal outcome","volume":"107","author":"Smith","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/01.AOG.0000172419.37410.eb","article-title":"Quad screen as a predictor of adverse pregnancy outcome","volume":"106","author":"Dugoff","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1479-828X.2008.00912.x","article-title":"First trimester predictors of adverse pregnancy outcomes","volume":"48","author":"Brameld","year":"2008","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ajog.2008.06.099","article-title":"Prediction of patient-specific risk for fetal loss using maternal characteristics and first- and second-trimester maternal serum Down syndrome markers","volume":"199","author":"Dugoff","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/uog.5163","article-title":"First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery","volume":"31","author":"Spencer","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib25","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/AOG.0b013e3181da93da","article-title":"First- and second-trimester maternal serum markers for aneuploidy and adverse obstetric outcomes","volume":"115","author":"Dugoff","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/pd.2489","article-title":"Second trimester serum predictors of preterm birth in a population-based sample of low-risk pregnancies","volume":"30","author":"Jelliffe-Pawlowski","year":"2010","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2013.02.012_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/AOG.0b013e3181a9479e","article-title":"Triple-marker prenatal screening program for chromosomal defects","volume":"114","author":"Kazerouni","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/AOG.0b013e31824be8f5","article-title":"Practitioner-specific medians for nuchal translucency to improve first-trimester screening performance","volume":"119","author":"Wu","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.clp.2010.01.004","article-title":"The role of regional collaboratives: the California Perinatal Quality Care Collaborative model","volume":"37","author":"Gould","year":"2010","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.ajog.2013.02.012_bib30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/pd.2802","article-title":"Detection rate of quadruple-marker screening determined by clinical follow-up and registry data in the statewide California program, July 2007 to February 2009","volume":"31","author":"Kazerouni","year":"2011","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2013.02.012_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijgo.2007.02.010","article-title":"Nuchal translucency as a predictor of adverse pregnancy outcome","volume":"98","author":"Piazze","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajog.2013.02.012_bib34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00404-007-0421-6","article-title":"The association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newborns","volume":"277","author":"Sayin","year":"2008","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ajog.2013.02.012_bib35","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0002-9378(82)90188-0","article-title":"Second-trimester placental changes associated with elevated maternal serum alpha-fetoprotein","volume":"144","author":"Perkes","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib36","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0002-9378(97)70019-X","article-title":"Elevated maternal serum midtrimester alpha-fetoprotein levels are associated with fetoplacental ischemia","volume":"177","author":"Spong","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib37","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1006\/bbrc.1994.1826","article-title":"Evidence that alpha-fetoprotein suppresses the immunological function in transgenic mice","volume":"201","author":"Yamashita","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajog.2013.02.012_bib38","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1476-5381.2009.00401.x","article-title":"Alpha-fetoprotein as a modulator of the pro-inflammatory response of human keratinocytes","volume":"158","author":"Potapovich","year":"2009","journal-title":"Br J Pharmacol"},{"issue":"suppl 1","key":"10.1016\/j.ajog.2013.02.012_bib39","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.ejogrb.2009.02.044","article-title":"Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour","volume":"144","author":"Shynlova","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2013.02.012_bib40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1600-0897.2011.01074.x","article-title":"Modulation of amniotic fluid activin-a and inhibin-a in women with preterm premature rupture of the membranes and infection-induced preterm birth","volume":"67","author":"Rosenberg","year":"2012","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2013.02.012_bib41","first-page":"533","article-title":"Placental pathology in pregnancy-induced hypertension (PIH) with or without intrauterine growth retardation","volume":"50","author":"Jain","year":"2007","journal-title":"Indian J Pathol Microbiol"},{"key":"10.1016\/j.ajog.2013.02.012_bib42","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1447-0756.2010.01408.x","article-title":"Comparison of risk factors for placental abruption and placenta previa: case-cohort study","volume":"37","author":"Matsuda","year":"2011","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.ajog.2013.02.012_bib43","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2147\/VHRM.S4009","article-title":"Pathophysiology of placentation abnormalities in pregnancy-induced hypertension","volume":"4","author":"Furuya","year":"2008","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.ajog.2013.02.012_bib44","first-page":"214","article-title":"Fetal cerebral maturation in hypertensive disorders of pregnancy","volume":"63","author":"Hadi","year":"1984","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib45","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1097\/00001756-200106130-00030","article-title":"Cerebral protection by hypoxic preconditioning in a murine model of focal ischemia-reperfusion","volume":"12","author":"Miller","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.ajog.2013.02.012_bib46","first-page":"321","article-title":"Effects of symmetric and asymmetric fetal growth on pregnancy outcomes","volume":"96","author":"Dashe","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib47","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ajog.2004.11.057","article-title":"Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia?","volume":"193","author":"Ancel","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.02.012_bib48","doi-asserted-by":"crossref","first-page":"v","DOI":"10.3310\/hta16020","article-title":"Pulse oximetry as a screening test for congenital heart defects in newborn infants: a test accuracy study with evaluation of acceptability and cost-effectiveness","volume":"16","author":"Ewer","year":"2012","journal-title":"Health Technol Assess"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937813001531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937813001531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:52:23Z","timestamp":1757587943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937813001531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0002937813001531"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2013.02.012","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2013.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}