{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:19:42Z","timestamp":1783696782713,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.ajog.2013.03.027","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T12:01:17Z","timestamp":1363953677000},"page":"415-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Is it time to sound an alarm about false-positive cell-free DNA testing for fetal aneuploidy?"],"prefix":"10.1016","volume":"209","author":[{"given":"Michael T.","family":"Mennuti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena M.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.D.","family":"Morrissette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Dugoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2013.03.027_bib1","article-title":"Clinical applications of maternal plasma fetal DNA analysis: translating the fruits of 15 years of research","volume":"51","author":"Chiu","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ajog.2013.03.027_bib2","doi-asserted-by":"crossref","first-page":"20458","DOI":"10.1073\/pnas.0810641105","article-title":"Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma","volume":"105","author":"Chiu","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajog.2013.03.027_bib3","doi-asserted-by":"crossref","first-page":"16266","DOI":"10.1073\/pnas.0808319105","article-title":"Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood","volume":"105","author":"Fan","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajog.2013.03.027_bib4","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/pd.3993","article-title":"Noninvasive prenatal aneuploidy testing of chromosome 13, 18, 21, X, and Y, using targeted sequencing of polymorphic loci","volume":"32","author":"Zimmerman","year":"2012","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2013.03.027_bib5","series-title":"Noninvasive prenatal testing for fetal aneuploidy; ACOG committee opinion no. 545","year":"2012"},{"key":"10.1016\/j.ajog.2013.03.027_bib6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/gim.2011.73","article-title":"DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study","volume":"14","author":"Palomaki","year":"2012","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2013.03.027_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2012.01.029","article-title":"Chromosome-selective sequencing of maternal plasma cell-free DNA for first-trimester detection of trisomy 21 and trisomy 18","volume":"206","author":"Ashoor","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.03.027_bib8","doi-asserted-by":"crossref","first-page":"319.e1","DOI":"10.1016\/j.ajog.2012.01.030","article-title":"Noninvasive prenatal detection and selective analysis of cell-free DNA obtained from maternal blood: evaluation for trisomy 21 and trisomy 18","volume":"206","author":"Sparks","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.03.027_bib9","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/AOG.0b013e31824fb482","article-title":"Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing","volume":"119","author":"Bianchi","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.03.027_bib10","doi-asserted-by":"crossref","first-page":"137.e1","DOI":"10.1016\/j.ajog.2012.05.021","article-title":"Non-invasive chromosomal evaluation (NICE) study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18","volume":"207","author":"Norton","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.03.027_bib11","first-page":"1","article-title":"Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test\u00a0for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors","volume":"9","author":"Dan","year":"2012","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2013.03.027_bib12","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1081::AID-PD682>3.0.CO;2-Z","article-title":"Revised guidelines for the diagnosis of mosaicism in amniocytes","volume":"19","author":"Hsu","year":"1999","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2013.03.027_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/fn.79.3.F223","article-title":"Confined placental mosaicism and intrauterine fetal growth","volume":"79","author":"Lestou","year":"1998","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.ajog.2013.03.027_bib14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/pd.1970140505","article-title":"Confined placental mosaicism, IUGR, and adverse pregnancy outcome: a controlled retrospective U.K. collaborative survey","volume":"14","author":"Wolstenholme","year":"1994","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2013.03.027_bib15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000053871","article-title":"Correlation of confined placental mosaicism with fetal intrauterine growth retardation: a case control study of placentas at delivery","volume":"16","author":"Stipoljev","year":"2001","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ajog.2013.03.027_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/uog.5133","article-title":"Prenatal testing for uniparental disomy: indications and clinical relevance","volume":"31","author":"Kotzot","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.03.027_bib17","series-title":"First-trimester screening for fetal aneuploidy; ACOG committee opinion no. 296","year":"2004"},{"key":"10.1016\/j.ajog.2013.03.027_bib18","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/AOG.0b013e318251e499","article-title":"Is cell-free fetal DNA from maternal blood finally ready for prime time?","volume":"119","author":"Simpson","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.03.027_bib19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nm0311-250","article-title":"Community Corner: Opening the Pandora's box of prenatal genetic testing","volume":"17","author":"Wright","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.ajog.2013.03.027_bib20","doi-asserted-by":"crossref","first-page":"374.e1","DOI":"10.1016\/j.ajog.2012.08.033","article-title":"Noninvasive prenatal testing for fetal trisomies in a routinely screened first-trimester population","volume":"207","author":"Nicolaides","year":"2012","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937813003013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937813003013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:54:27Z","timestamp":1757588067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937813003013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0002937813003013"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2013.03.027","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is it time to sound an alarm about false-positive cell-free DNA testing for fetal aneuploidy?","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2013.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}