{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:21:55Z","timestamp":1793384515132,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.ajog.2013.12.043","type":"journal-article","created":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T00:46:09Z","timestamp":1393029969000},"page":"221.e1-221.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Distinct cervical microRNA profiles are present in women destined to have a preterm birth"],"prefix":"10.1016","volume":"210","author":[{"given":"Michal A.","family":"Elovitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy G.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Anton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Gilstrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Heiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Bastek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2013.12.043_bib1","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa035140","article-title":"Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate","volume":"348","author":"Meis","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2013.12.043_bib2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1056\/NEJMoa067815","article-title":"Progesterone and the risk of preterm birth among women with a short cervix","volume":"357","author":"Fonseca","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2013.12.043_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1067\/mob.2003.41","article-title":"Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study","volume":"188","author":"da Fonseca","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib4","doi-asserted-by":"crossref","first-page":"375.e1","DOI":"10.1016\/j.ajog.2009.08.015","article-title":"Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length","volume":"201","author":"Owen","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0002-9378(96)80051-2","article-title":"The preterm prediction study: risk factors in twin gestations: National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network","volume":"175","author":"Goldenberg","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/uog.9017","article-title":"Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial","volume":"38","author":"Hassan","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1530\/REP-07-0032","article-title":"Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice","volume":"134","author":"Read","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.ajog.2013.12.043_bib8","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1210\/en.2006-0851","article-title":"Dynamic changes in the cervical epithelial tight junction complex and differentiation occur during cervical ripening and parturition","volume":"148","author":"Timmons","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2013.12.043_bib9","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1210\/en.2011-1950","article-title":"Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth","volume":"153","author":"Akgul","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2013.12.043_bib10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jri.2009.12.004","article-title":"Pro-inflammatory and anti-inflammatory cytokines in human preterm and term cervical ripening","volume":"84","author":"Dubicke","year":"2010","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ajog.2013.12.043_bib11","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1095\/biolreprod.108.075309","article-title":"Preterm and term cervical ripening in CD1 Mice (Mus musculus): similar or divergent molecular mechanisms?","volume":"81","author":"Gonzalez","year":"2009","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2013.12.043_bib12","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ajog.2006.06.021","article-title":"The transcriptome of the uterine cervix before and after spontaneous term parturition","volume":"195","author":"Hassan","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3109\/14767050903353216","article-title":"The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this process","volume":"22","author":"Hassan","year":"2009","journal-title":"J\u00a0Matern Fetal Neonat"},{"key":"10.1016\/j.ajog.2013.12.043_bib14","doi-asserted-by":"crossref","first-page":"472.e1","DOI":"10.1016\/j.ajog.2010.06.076","article-title":"The molecular basis for sonographic cervical shortening at term: identification of differentially expressed genes and the epithelial-mesenchymal transition as a function of cervical length","volume":"203","author":"Hassan","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib15","doi-asserted-by":"crossref","first-page":"208.e1","DOI":"10.1016\/j.ajog.2011.12.036","article-title":"Inflammation promotes a cytokine response and disrupts the cervical epithelial barrier: a possible mechanism of premature cervical remodeling and preterm birth","volume":"206","author":"Nold","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fncel.2013.00136","article-title":"The interplay of microRNA and neuronal activity in health and disease","volume":"7","author":"Eacker","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.ajog.2013.12.043_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-007-5590-1_1","article-title":"MicroRNAs in human cancer","volume":"774","author":"Farazi","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ajog.2013.12.043_bib18","article-title":"MicroRNA as biomarkers and regulator of cardiovascular development and disease","author":"Hagiwara","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ajog.2013.12.043_bib19","doi-asserted-by":"crossref","first-page":"5704","DOI":"10.2174\/13816128113199990364","article-title":"MicroRNAs as early biomarkers in obesity and related metabolic and cardiovascular diseases","volume":"19","author":"Hulsmans","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ajog.2013.12.043_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.autrev.2010.07.002","article-title":"MicroRNAs in autoimmunity and inflammatory bowel disease: crucial regulators in immune response","volume":"11","author":"Iborra","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.ajog.2013.12.043_bib21","doi-asserted-by":"crossref","unstructured":"Ma R, Jiang T, Kang X. Circulating microRNAs in cancer: origin, function and application. J Exp Clin Cancer Res 30 2012;31:38.","DOI":"10.1186\/1756-9966-31-38"},{"key":"10.1016\/j.ajog.2013.12.043_bib22","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00018-011-0775-6","article-title":"MicroRNAs mediate metabolic stresses and angiogenesis","volume":"69","author":"Patella","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ajog.2013.12.043_bib23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.arbres.2012.04.011","article-title":"Role of microRNAs in lung disease","volume":"48","author":"Angulo","year":"2012","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.ajog.2013.12.043_bib24","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1161\/CIRCRESAHA.111.247437","article-title":"Differential expression of microRNAs in different disease states","volume":"110","author":"Abdellatif","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.ajog.2013.12.043_bib25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.biotechadv.2012.01.006","article-title":"Exploiting microRNAs for cell engineering and therapy","volume":"30","author":"Bratkovic","year":"2012","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.ajog.2013.12.043_bib26","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1111\/j.1755-5922.2010.00220.x","article-title":"MicroRNA-based therapeutic approaches in the cardiovascular system","volume":"30","author":"Fiedler","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.ajog.2013.12.043_bib27","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.bcp.2011.08.007","article-title":"Targeting microRNAs involved in human diseases: a novel approach for modification of gene expression and drug development","volume":"82","author":"Gambari","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajog.2013.12.043_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/AOG.0b013e31829ab714","article-title":"Biomarkers and cervical length to predict spontaneous preterm birth in asymptomatic high-risk women","volume":"122","author":"Bastek","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib29","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1159\/000331298","article-title":"Analysis of mRNA quality in freshly prepared and archival Papanicolaou samples","volume":"43","author":"Chuaqui","year":"1999","journal-title":"Acta Cytol"},{"key":"10.1016\/j.ajog.2013.12.043_bib30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJM199602293340904","article-title":"The length of the cervix and the risk of spontaneous premature delivery: National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network","volume":"334","author":"Iams","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2013.12.043_bib31","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.ajpath.2013.07.021","article-title":"MiR-210 inhibits trophoblast invasion and is a serum biomarker for preeclampsia","volume":"183","author":"Anton","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajog.2013.12.043_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/humrep\/der362","article-title":"Lipopolysaccharide induces cytokine production and decreases extravillous trophoblast invasion through a mitogen-activated protein kinase-mediated pathway: possible mechanisms of first trimester placental dysfunction","volume":"27","author":"Anton","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2013.12.043_bib33","doi-asserted-by":"crossref","first-page":"223.e1","DOI":"10.1016\/j.ajog.2013.01.020","article-title":"Prevention of preterm birth by progestational agents: what are the molecular mechanisms?","volume":"208","author":"Nold","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib34","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1091\/mbc.e13-06-0298","article-title":"JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function","volume":"24","author":"Monteiro","year":"2013","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajog.2013.12.043_bib35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1053\/j.semperi.2009.06.006","article-title":"Prevention of preterm birth based on short cervix: progesterone","volume":"33","author":"da Fonseca","year":"2009","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajog.2013.12.043_bib36","doi-asserted-by":"crossref","first-page":"314.e1","DOI":"10.1016\/j.ajog.2008.01.029","article-title":"Preventing cervical ripening: the primary mechanism by which progestational agents prevent preterm birth?","volume":"198","author":"Xu","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib37","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1210\/en.2012-1577","article-title":"Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice","volume":"153","author":"Soh","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2013.12.043_bib38","doi-asserted-by":"crossref","first-page":"e68547","DOI":"10.1371\/journal.pone.0068547","article-title":"Microbial products induce claudin-2 to compromise gut epithelial barrier function","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2013.12.043_bib39","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/jcp.2004.021840","article-title":"Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease","volume":"58","author":"Sanders","year":"2005","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.ajog.2013.12.043_bib40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fimmu.2013.00280","article-title":"Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics","volume":"4","author":"Pastorelli","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajog.2013.12.043_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrendo.2013.96","article-title":"MicroRNAs\u2014mediators of myometrial contractility during pregnancy and labour","volume":"9","author":"Renthal","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ajog.2013.12.043_bib42","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1210\/me.2012-1199","article-title":"The microRNA (miR)-199a\/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor","volume":"26","author":"Williams","year":"2012","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ajog.2013.12.043_bib43","doi-asserted-by":"crossref","first-page":"20828","DOI":"10.1073\/pnas.1008301107","article-title":"MiR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor","volume":"107","author":"Renthal","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2013.12.043_bib44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/path.2463","article-title":"Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition","volume":"217","author":"Montenegro","year":"2009","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.ajog.2013.12.043_bib45","doi-asserted-by":"crossref","first-page":"80.e1","DOI":"10.1016\/j.ajog.2009.08.016","article-title":"MicroRNA expression profiling of the human uterine cervix after term labor and delivery","volume":"202","author":"Hassan","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib46","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1161\/CIRCGENETICS.110.958702","article-title":"MiR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells","volume":"4","author":"Rangrez","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.ajog.2013.12.043_bib47","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1101\/gad.1842409","article-title":"MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury","volume":"23","author":"Xin","year":"2009","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajog.2013.12.043_bib48","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1152\/physiolgenomics.00146.2010","article-title":"Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?","volume":"43","author":"Albinsson","year":"2011","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.ajog.2013.12.043_bib49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.leukres.2011.10.006","article-title":"Inhibition of the miR-143\/145 cluster attenuated neutrophil differentiation of APL cells","volume":"36","author":"Batliner","year":"2012","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajog.2013.12.043_bib50","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1021\/pr300600r","article-title":"Effects of the miR-143\/-145 microRNA cluster on the colon cancer proteome and transcriptome","volume":"11","author":"Bauer","year":"2012","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.ajog.2013.12.043_bib51","doi-asserted-by":"crossref","first-page":"28312","DOI":"10.1074\/jbc.M111.221945","article-title":"The miR-143\/145 cluster is a novel transcriptional target of Jagged-1\/Notch signaling in vascular smooth muscle cells","volume":"286","author":"Boucher","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ajog.2013.12.043_bib52","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nature08195","article-title":"MiR-145 and miR-143 regulate smooth muscle cell fate and plasticity","volume":"460","author":"Cordes","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2013.12.043_bib53","first-page":"447","article-title":"Inflammation on the cervical Papanicolaou smear: the predictive value for infection in asymptomatic women","volume":"24","author":"Bertolino","year":"1992","journal-title":"Fam Med"},{"key":"10.1016\/j.ajog.2013.12.043_bib54","first-page":"997","article-title":"The significance of moderate and severe inflammation on class I Papanicolaou smear","volume":"76","author":"Lawley","year":"1990","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2013.12.043_bib55","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1053\/j.gastro.2010.07.040","article-title":"MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function","volume":"139","author":"McKenna","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajog.2013.12.043_bib56","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/j.gastro.2011.07.005","article-title":"MicroRNA regulation of intestinal epithelial tight junction permeability","volume":"141","author":"Ye","year":"2011","journal-title":"Gastroenterology"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937813022886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937813022886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:56:11Z","timestamp":1757588171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937813022886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0002937813022886"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2013.12.043","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct cervical microRNA profiles are present in women destined to have a preterm birth","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2013.12.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}