{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:57:27Z","timestamp":1789851447890,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ajog.2014.03.069","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T10:17:54Z","timestamp":1396520274000},"page":"385.e1-385.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes"],"prefix":"10.1016","volume":"211","author":[{"given":"Marian","family":"Kacerovsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Musilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Hornychova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radka","family":"Kutova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Pliskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Kostal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jacobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2014.03.069_bib1","first-page":"178","article-title":"Preterm premature rupture of the membranes","volume":"101","author":"Mercer","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.0001-6349.2005.00765.x","article-title":"Preterm birth in Sweden 1973-2001: rate, subgroups, and effect of changing patterns in multiple births, maternal age and smoking","volume":"84","author":"Morken","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2014.03.069_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0897.2010.00830.x","article-title":"Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes","volume":"64","author":"DiGiulio","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2014.03.069_bib4","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/S0002-9378(98)70142-5","article-title":"Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments","volume":"179","author":"Yoon","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/00003081-199112000-00013","article-title":"Microbial invasion of the amniotic cavity in premature rupture of membranes","volume":"34","author":"Romero","year":"1991","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib6","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3109\/14767058.2012.671873","article-title":"Intraamniotic inflammatory response to bacteria: analysis of multiple amniotic fluid proteins in women with preterm prelabor rupture of membranes","volume":"25","author":"Kacerovsky","year":"2012","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2014.03.069_bib7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0002-9378(93)90014-A","article-title":"A\u00a0comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes","volume":"169","author":"Romero","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib8","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3109\/14767058.2012.666592","article-title":"A\u00a0prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid","volume":"25","author":"Cobo","year":"2012","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2014.03.069_bib9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/01.AOG.0000295866.97499.35","article-title":"Extreme preterm birth: onset of delivery and its effect on infant survival and morbidity","volume":"111","author":"Johanzon","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib10","doi-asserted-by":"crossref","first-page":"e43677","DOI":"10.1371\/journal.pone.0043677","article-title":"Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes","volume":"7","author":"Cobo","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.ajog.2014.03.069_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3109\/14767058.2013.765404","article-title":"The fetal inflammatory response in subgroups of women with preterm prelabor rupture of the membranes","volume":"26","author":"Kacerovsky","year":"2013","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2014.03.069_bib12","first-page":"799","article-title":"Relationship between C-reactive protein levels and intraamniotic infection in women with preterm labor","volume":"38","author":"Mazor","year":"1993","journal-title":"J\u00a0Reprod Med"},{"key":"10.1016\/j.ajog.2014.03.069_bib13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3109\/14767058.2013.844123","article-title":"The diagnostic performance of the Mass Restricted (MR) score in the identification of microbial invasion of the amniotic cavity or intra-amniotic inflammation is not superior to amniotic fluid interleukin-6","volume":"27","author":"Romero","year":"2014","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2014.03.069_bib14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ajog.2004.07.015","article-title":"Detection of interleukin-6 in vaginal secretions of women with preterm premature rupture of membranes and its association with neonatal infection: a rapid immunochromatographic test","volume":"192","author":"Kayem","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib15","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3109\/14767058.2011.558954","article-title":"Interleukin-6 bedside testing in women at high risk of preterm birth","volume":"24","author":"Vousden","year":"2011","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2014.03.069_bib16","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3109\/14767058.2013.829814","article-title":"Rapid evaluation of the absence of inflammation after rupture of\u00a0membranes","volume":"27","author":"Berthiaume","year":"2014","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2014.03.069_bib17","unstructured":"The Czech Society of Obstetrics and Gynecology. Clinical Guidelines in Obstetrics. 2007. Available at: www.perinatologie.cz [in Czech]. Accessed DATE."},{"key":"10.1016\/j.ajog.2014.03.069_bib18","doi-asserted-by":"crossref","first-page":"213.e1","DOI":"10.1016\/j.ajog.2011.04.028","article-title":"The microbial load with genital mycoplasmas correlates with the degree of histologic chorioamnionitis in preterm PROM","volume":"205","author":"Kacerovsky","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"3 Pt 1","key":"10.1016\/j.ajog.2014.03.069_bib19","first-page":"383","article-title":"The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies","volume":"73","author":"Salafia","year":"1989","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/1043-4666(91)90037-E","article-title":"Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection","volume":"3","author":"Santhanam","year":"1991","journal-title":"Cytokine"},{"key":"10.1016\/j.ajog.2014.03.069_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1034\/j.1600-0412.2003.00157.x","article-title":"Microbial invasion and cytokine response in amniotic fluid in a Swedish population of women with preterm prelabor rupture of membranes","volume":"82","author":"Jacobsson","year":"2003","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2014.03.069_bib22","first-page":"491","article-title":"Study of interleukin-6 and tumor necrosis factor-alpha levels in maternal serum and amniotic fluid of patients with premature rupture of membranes","volume":"26","author":"Weiyuan","year":"1998","journal-title":"J\u00a0Perinat Med"},{"key":"10.1016\/j.ajog.2014.03.069_bib23","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/0002-9378(95)90028-4","article-title":"Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity","volume":"172","author":"Yoon","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib24","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0002-9378(98)70144-9","article-title":"Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection","volume":"179","author":"Hsu","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib25","first-page":"311","article-title":"Changes in cytokine (IL-8, IL-6 and TNF-alpha) levels in the amniotic fluid and maternal serum in patients with premature rupture of the membranes","volume":"63","author":"Zhang","year":"2000","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"10.1016\/j.ajog.2014.03.069_bib26","doi-asserted-by":"crossref","first-page":"342.e1","DOI":"10.1016\/j.ajog.2012.01.004","article-title":"The impact of the microbial load of\u00a0genital mycoplasmas and gestational age\u00a0on\u00a0the intensity of intraamniotic inflammation","volume":"206","author":"Kacerovsky","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2014.03.069_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/00016340802572646","article-title":"Quantification of Ureaplasma urealyticum DNA in the amniotic fluid form patients in PTL and pPROM and its relation to inflammatory cytokine levels","volume":"88","author":"Jacobsson","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2014.03.069_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.diagmicrobio.2009.12.023","article-title":"The bacterial load of Ureaplasma parvum in amniotic fluid is correlated with an\u00a0increased intrauterine inflammatory response","volume":"67","author":"Kasper","year":"2010","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293781400338X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293781400338X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:59:16Z","timestamp":1757588356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293781400338X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S000293781400338X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2014.03.069","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2014.03.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}