{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:29:25Z","timestamp":1768343365681,"version":"3.49.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.ajog.2015.02.001","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T12:48:26Z","timestamp":1423054106000},"page":"51.e1-51.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Amplification of the 3q chromosomal region as a specific marker in cervical cancer"],"prefix":"10.1016","volume":"213","author":[{"given":"Thomas C.","family":"Wright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Compagno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Grazioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogita","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Kershnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Triantafyllos","family":"Tafas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Kilpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2015.02.001_bib1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7326\/0003-4819-132-10-200005160-00009","article-title":"Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review","volume":"132","author":"Nanda","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajog.2015.02.001_bib2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/jnci\/djq562","article-title":"Human papillomavirus testing in the prevention of cervical cancer","volume":"103","author":"Schiffman","year":"2011","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ajog.2015.02.001_bib3","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/S0140-6736(04)17354-6","article-title":"Regression of low-grade squamous intra-epithelial lesions in young women","volume":"364","author":"Moscicki","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2015.02.001_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jnci\/92.5.397","article-title":"The ALTS Group. Human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial","volume":"92","author":"Koutsky","year":"2000","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ajog.2015.02.001_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/AOG.0b013e31818f5008","article-title":"Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2","volume":"113","author":"Castle","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.02.001_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygyno.2008.01.040","article-title":"Gain of the 3q26 region in cervicovaginal liquid-based pap preparations is associated with squamous intraepithelial lesions and squamous cell carcinoma","author":"Caraway","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2015.02.001_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1098-2264(199708)19:4<233::AID-GCC5>3.0.CO;2-Y","article-title":"Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q","volume":"19","author":"Heselmeyer","year":"1997","journal-title":"Genes Chromosom Cancer"},{"key":"10.1016\/j.ajog.2015.02.001_bib8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/path.2070","article-title":"Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer","volume":"210","author":"Hopman","year":"2006","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.ajog.2015.02.001_bib9","doi-asserted-by":"crossref","first-page":"604","DOI":"10.2353\/jmoldx.2007.070007","article-title":"Chromosomal biomarkers for detection of human papillomavirus associated genomic instability in epithelial cells of cervical cytology specimens","volume":"9","author":"Sokolova","year":"2007","journal-title":"J\u00a0Mol Diag"},{"key":"10.1016\/j.ajog.2015.02.001_bib10","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0002-9440(10)62341-3","article-title":"Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer","volume":"166","author":"Heselmeyer-Haddad","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajog.2015.02.001_bib11","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2353\/ajpath.2009.090122","article-title":"Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears","volume":"175","author":"Andersson","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajog.2015.02.001_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ygyno.2009.03.031","article-title":"Gain of 3q26: a genetic marker in low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix","volume":"114","author":"Seppo","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2015.02.001_bib13","series-title":"Molecular diagnostics of human cancer","first-page":"209","article-title":"The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses","author":"Manos","year":"1989"},{"key":"10.1016\/j.ajog.2015.02.001_bib14","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)63498-0","article-title":"Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia","volume":"163","author":"Heselmeyer-Haddad","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajog.2015.02.001_bib15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ygyno.2013.06.005","article-title":"Chromosomal gains measured in cytology samples from women with abnormal cervical cancer screening results","volume":"130","author":"Luhn","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2015.02.001_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.hrtlng.2013.01.006","article-title":"Unpacking the 2\u00d72 table","volume":"42","author":"Parshall","year":"2013","journal-title":"Heart Lung"},{"key":"10.1016\/j.ajog.2015.02.001_bib17","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.ajog.2004.03.055","article-title":"Automated detection of rara fetal cells in maternal blood: eliminating the false-positive XY signals in XX pregnancies","volume":"190","author":"Kilpatrick","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.02.001_bib18","doi-asserted-by":"crossref","first-page":"581.e1","DOI":"10.1016\/j.ajog.2009.12.016","article-title":"Amplification of the chromosome 3q26 region shows high negative predictive value for nonmalignant transformation of LSIL cytologic finding","volume":"202","author":"Jalali","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.02.001_bib19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S1470-2045(11)70188-7","article-title":"Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study","volume":"12","author":"Castle","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ajog.2015.02.001_bib20","doi-asserted-by":"crossref","first-page":"e39101","DOI":"10.1371\/journal.pone.0039101","article-title":"3q26 amplification is an effective negative triage test for LSIL: a historical prospective study","volume":"7","author":"Heitmann","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2015.02.001_bib21","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/IGC.0b013e31825104bd","article-title":"Role of chromosome 3q26 in predicting progression of cervical dysplasia","volume":"22","author":"Rodolakis","year":"2012","journal-title":"Int J Gynecol Cancer"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815001155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815001155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:02:23Z","timestamp":1757588543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937815001155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0002937815001155"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2015.02.001","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amplification of the 3q chromosomal region as a specific marker in cervical cancer","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2015.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}