{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:49:56Z","timestamp":1760906996335,"version":"3.44.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.ajog.2015.06.028","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T12:53:28Z","timestamp":1434286408000},"page":"511.e1-511.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association between ovarian stimulators with or without intrauterine insemination, and assisted reproductive technologies on multiple births"],"prefix":"10.1016","volume":"213","author":[{"given":"Sonia","family":"Chaabane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile","family":"Sheehy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Monnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Bissonnette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquetta M.","family":"Trasler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anick","family":"B\u00e9rard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2015.06.028_bib1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.fertnstert.2011.11.048","article-title":"Multiple gestation associated with infertility therapy: an American Society for Reproductive Medicine practice committee opinion","volume":"97","author":"Pfeifer","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib2","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(05)66478-1","article-title":"Multiple birth resulting from ovarian stimulation for subfertility treatment","volume":"365","author":"Fauser","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2015.06.028_bib3","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.fertnstert.2009.09.009","article-title":"International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009","volume":"92","author":"Zegers-Hochschild","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1677\/joe.0.0080386","article-title":"Observations on fetal growth in multiple pregnancy in man","volume":"8","author":"McKeown","year":"1952","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.ajog.2015.06.028_bib5","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2105\/AJPH.92.8.1323","article-title":"The impact of the increasing number of multiple births on the rates of preterm birth and low birthweight: an international study","volume":"92","author":"Blondel","year":"2002","journal-title":"Am J Public Health"},{"key":"10.1016\/j.ajog.2015.06.028_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/(SICI)1096-8628(19990312)83:2<117::AID-AJMG7>3.0.CO;2-4","article-title":"Congenital malformations in twins: an international study","volume":"83","author":"Mastroiacovo","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.ajog.2015.06.028_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/sper.2002.34775","article-title":"Trends in the occurrence, determinants, and consequences of multiple births","volume":"26","author":"Blondel","year":"2002","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajog.2015.06.028_bib8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jpeds.2011.02.017","article-title":"The epidemic of multiple gestations and neonatal intensive care unit use: the cost of irresponsibility","volume":"159","author":"Janvier","year":"2011","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ajog.2015.06.028_bib9","unstructured":"Public Health Agency of Canada. Canadian perinatal health report, 2008 ed. Ottawa 2008. Available at http:\/\/www.violapolomeno.com\/cphr-rspc08-eng.pdf. Accessed July 28, 2015."},{"key":"10.1016\/j.ajog.2015.06.028_bib10","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1056\/NEJMoa1301467","article-title":"Fertility treatments and multiple births in the United States","volume":"369","author":"Kulkarni","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.06.028_bib11","unstructured":"CANSIM; Statistics Canada. Table\u00a0102-4515\u2013Live births and fetal deaths (stillbirths), by type (single or multiple), Canada, provinces and territories, annual (number) 1991-2011. Available at: http:\/\/www5.statcan.gc.ca\/cansim\/a47. Accessed June 5,\u00a02014."},{"key":"10.1016\/j.ajog.2015.06.028_bib12","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/humrep\/deu067","article-title":"Universal coverage of IVF pays off","volume":"29","author":"V\u00e9lez","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2015.06.028_bib13","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMsa032073","article-title":"Trends in embryo-transfer practice and in outcomes of the use of assisted reproductive technology in the United States","volume":"350","author":"Jain","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.06.028_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1056\/NEJM199808273390901","article-title":"Reducing the risk of multiple births by transfer of two embryos after in\u00a0vitro fertilization","volume":"339","author":"Templeton","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.06.028_bib15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/apa.12145","article-title":"The paediatric consequences of assisted reproductive technologies, with special emphasis on multiple pregnancies","volume":"102","author":"Barrington","year":"2013","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.ajog.2015.06.028_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1056\/NEJM199901213400302","article-title":"Efficacy of superovulation and intrauterine insemination in the treatment of infertility","volume":"340","author":"Guzick","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.06.028_bib17","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1542\/peds.111.S1.1159","article-title":"Trends in multiple births conceived using assisted reproductive technology, United States, 1997-2000","volume":"111","author":"Reynolds","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2015.06.028_bib18","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.fertnstert.2012.02.031","article-title":"Ovarian stimulation and intrauterine insemination at the quarter centennial: implications for the multiple births epidemic","volume":"97","author":"McClamrock","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib19","unstructured":"Gunby J. Assisted reproductive technologies (ART) in Canada: 2011 results from the Canadian ART register (CARTR). Canadian Fertility and Andrology Society. Available at: https:\/\/www.cfas.ca\/images\/stories\/pdf\/CARTR_2011_v4.pdf. Accessed July 28, 2015."},{"key":"10.1016\/j.ajog.2015.06.028_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/pds.1558","article-title":"Agreement between administrative databases and medical charts for pregnancy-related variables among asthmatic women","volume":"17","author":"Vilain","year":"2008","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.ajog.2015.06.028_bib21","unstructured":"Health Canada. Canadian guidelines for body weight classification in adults. Available at: http:\/\/www.hc-sc.gc.ca\/fn-an\/nutrition\/weights-poids\/guide-ld-adult\/qa-qr-pub-eng.php#1. Accessed Dec.\u00a015, 2013."},{"key":"10.1016\/j.ajog.2015.06.028_bib22","unstructured":"Assisted Reproduction Center. Infertility: questions and answers. Available at: https:\/\/www.chu-sainte-justine.org\/cliniques\/page.aspx?Id_Page=10006789&item=97000. Accessed May\u00a09, 2014."},{"key":"10.1016\/j.ajog.2015.06.028_bib23","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/humrep\/del495","article-title":"Infertility, infertility treatment and twinning: the Danish national birth cohort","volume":"22","author":"Zhu","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2015.06.028_bib24","first-page":"414","article-title":"Neonatal outcome in pregnancies from ovarian stimulation","volume":"100","author":"Kallen","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.06.028_bib25","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.fertnstert.2009.04.022","article-title":"A\u00a0randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial","volume":"94","author":"Reindollar","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.fertnstert.2004.05.095","article-title":"Use of a prediction model for high-order multiple implantation after ovarian stimulation with gonadotropins","volume":"83","author":"Tur","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib27","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S0140-6736(87)92688-2","article-title":"Increased monozygotic twinning rate after ovulation induction","volume":"329","author":"Derom","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2015.06.028_bib28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1472-6483(10)62069-X","article-title":"Infertility therapy-associated multiple pregnancies (births): an ongoing epidemic","volume":"7","author":"Adashi","year":"2003","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ajog.2015.06.028_bib29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1530\/REP-08-0206","article-title":"Monozygotic twinning associated with assisted reproductive technologies: a review","volume":"136","author":"Aston","year":"2008","journal-title":"Reproduction"},{"key":"10.1016\/j.ajog.2015.06.028_bib30","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.fertnstert.2008.12.035","article-title":"Nulliparity, fertility treatments and twins: a time for rethinking","volume":"93","author":"Berkovitz","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib31","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.rbmo.2011.05.020","article-title":"Working to eliminate multiple pregnancies: a success story in Qu\u00e9bec","volume":"23","author":"Bissonnette","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ajog.2015.06.028_bib32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1701-2163(16)34909-X","article-title":"Multiple births associated with assisted human reproduction in Canada","volume":"33","author":"Cook","year":"2011","journal-title":"J\u00a0Obstet Gynaecol Can"},{"key":"10.1016\/j.ajog.2015.06.028_bib33","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.fertnstert.2010.12.018","article-title":"Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer","volume":"95","author":"Kawachiya","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.fertnstert.2014.03.039","article-title":"What makes them split? Identifying risk factors that lead to monozygotic twins after in\u00a0vitro fertilization","volume":"102","author":"Knopman","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1479-828X.2005.00451.x","article-title":"Is there increased monozygotic twinning after assisted reproductive technology?","volume":"45","author":"Toledo","year":"2005","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2015.06.028_bib36","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/bmj.38919.495718.AE","article-title":"Infertility, infertility treatment, and congenital malformations: Danish national birth cohort","volume":"333","author":"Zhu","year":"2006","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2015.06.028_bib37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/humrep\/deq313","article-title":"Use of clomiphene citrate and birth defects, National Birth Defects Prevention Study, 1997\u20132005","volume":"26","author":"Reefhuis","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2015.06.028_bib38","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/humrep\/den387","article-title":"Assisted reproductive technology and major structural birth defects in the United States","volume":"24","author":"Reefhuis","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2015.06.028_bib39","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/pds.1731","article-title":"Herbal products use during pregnancy: prevalence and predictors","volume":"18","author":"Moussally","year":"2009","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.ajog.2015.06.028_bib40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10654-012-9654-1","article-title":"Impact of maternal asthma on perinatal outcomes: a two-stage sampling cohort study","volume":"27","author":"Firoozi","year":"2012","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ajog.2015.06.028_bib41","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0015-0282(00)00602-6","article-title":"Does assisted hatching pose a risk for monozygotic twinning in pregnancies conceived through in\u00a0vitro fertilization?","volume":"74","author":"Schieve","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib42","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/humupd\/dmr039","article-title":"Ovarian antral folliculogenesis during the human menstrual cycle: a review","volume":"18","author":"Baerwald","year":"2012","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2015.06.028_bib43","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0015-0282(01)02379-2","article-title":"Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicular reduction","volume":"76","author":"Albano","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2015.06.028_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-7827-12-3","article-title":"Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials","volume":"12","author":"Palomba","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ajog.2015.06.028_bib45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/1471-0528.12070","article-title":"Effects of metformin in women with polycystic ovary syndrome treated with gonadotropins for in\u00a0vitro fertilization and intracytoplasmatic sperm injection cycles: a systematic review and meta-analysis of randomized controlled trials","volume":"120","author":"Palomba","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2015.06.028_bib46","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/humrep\/dep466","article-title":"Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response","volume":"25","author":"Palomba","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2015.06.028_bib47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00404-002-0447-8","article-title":"The effect of metformin treatment to ovarian response in cases with PCOS","volume":"269","author":"Tasdemir","year":"2004","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ajog.2015.06.028_bib48","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/humrep\/dei130","article-title":"A\u00a0randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination","volume":"20","author":"Palomba","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2015.06.028_bib49","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1447-0756.2012.02072.x","article-title":"Pretreatment and co-administration of oral anti-diabetic agent with clomiphene citrate or rFSH for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome","volume":"39","author":"Begum","year":"2013","journal-title":"J\u00a0Obstet Gynaecol Res"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815006250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815006250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:05:14Z","timestamp":1757588714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937815006250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0002937815006250"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2015.06.028","relation":{},"ISSN":["0002-9378"],"issn-type":[{"type":"print","value":"0002-9378"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between ovarian stimulators with or without intrauterine insemination, and assisted reproductive technologies on multiple births","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2015.06.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}