{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:31:01Z","timestamp":1783488661296,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.ajog.2015.09.068","type":"journal-article","created":{"date-parts":[[2015,9,27]],"date-time":"2015-09-27T00:08:43Z","timestamp":1443312523000},"page":"279.e1-279.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Down-regulation of placental neuropilin-1 in fetal growth restriction"],"prefix":"10.1016","volume":"214","author":[{"given":"Dev","family":"Maulik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"De","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Ragolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Grigoryev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamani","family":"Lankachandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolene","family":"Muscat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Gerkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2015.09.068_bib1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1542\/peds.86.5.707","article-title":"The impact of intrauterine growth retardation and body proportionality on fetal and neonatal outcome","volume":"85","author":"Kramer","year":"1990","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2015.09.068_bib2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00003081-200606000-00008","article-title":"Perinatal outcome and later implications of intrauterine growth restriction","volume":"49","author":"Pallotto","year":"2006","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1203\/00006450-199511000-00017","article-title":"Growth in full-term small-for-gestational-age infants: from birth to final height","volume":"38","author":"Karlberg","year":"1995","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajog.2015.09.068_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/jama.283.5.625","article-title":"Adult functional outcome of those born small for gestational age","volume":"283","author":"Strauss","year":"2000","journal-title":"JAMA"},{"issue":"Suppl","key":"10.1016\/j.ajog.2015.09.068_bib5","first-page":"S54","article-title":"Neurodevelopmental outcome of small-for-gestational-age infants","volume":"52","author":"Goldenberg","year":"1998","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.ajog.2015.09.068_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1542\/peds.108.1.111","article-title":"School difficulties in 20-year-olds who were born small for gestational age at term in a regional cohort study","volume":"108","author":"Larroque","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2015.09.068_bib7","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00003081-200606000-00009","article-title":"Adult consequences of fetal growth restriction","volume":"49","author":"Barker","year":"2006","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib8","first-page":"906","article-title":"Fetal deprivation and placental insufficiency","volume":"37","author":"Gruenwald","year":"1971","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000240380","article-title":"Fetal growth retardation produced by experimental placental insufficiency in the rhesus monkey, I: body weight, organ size","volume":"18","author":"Myers","year":"1971","journal-title":"Biol Neonate"},{"key":"10.1016\/j.ajog.2015.09.068_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.clp.2010.12.004","article-title":"Umbilical artery Doppler in the assessment of fetal growth restriction","volume":"38","author":"Maulik","year":"2011","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.ajog.2015.09.068_bib11","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0140-6736(94)90457-X","article-title":"Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery","volume":"344","author":"Karsdorp","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2015.09.068_bib12","series-title":"Doppler ultrasound in obstetrics and gynecology","first-page":"363","article-title":"Doppler velocimetry for fetal surveillance: adverse perinatal outcome and fetal hypoxia","author":"Maulik","year":"2005"},{"key":"10.1016\/j.ajog.2015.09.068_bib13","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/S0002-9378(96)70103-5","article-title":"Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree","volume":"175","author":"Krebs","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib14","first-page":"499","article-title":"Umbilical Doppler waveforms and placental villous angiogenesis in pregnancies complicated by fetal growth restriction","volume":"93","author":"Todros","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2015.09.068_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14767050802034545","article-title":"The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment forthe subsequent development of preeclampsia and small-for-gestational age","volume":"21","author":"Erez","year":"2008","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.09.068_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/14767050701830480","volume":"21","author":"Romero","year":"2008","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.09.068_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/14767050701413022","article-title":"Unexplained fetal death: another anti-angiogenic state","volume":"20","author":"Espinoza","year":"2007","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.09.068_bib19","doi-asserted-by":"crossref","first-page":"287.e1","DOI":"10.1016\/j.ajog.2013.01.016","article-title":"Maternal plasma concentrations of angiogenic\/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia","volume":"208","author":"Chaiworapongsa","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib20","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3109\/14767050902994838","article-title":"A\u00a0subset of patients destined to develop spontaneous preterm labor has an abnormal angiogenic\/anti-angiogenic profile in maternal plasma: evidence in support of pathophysiologic heterogeneity of preterm labor derived from a longitudinal study","volume":"22","author":"Chaiworapongsa","year":"2009","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.09.068_bib21","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3109\/14767058.2013.784256","article-title":"Maternal plasma concentrations of sST2 and angiogenic\/anti-angiogenic factors in preeclampsia","volume":"26","author":"Stampalija","year":"2013","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.09.068_bib22","doi-asserted-by":"crossref","first-page":"310.e1","DOI":"10.1016\/j.ajog.2013.01.017","article-title":"Evidence of an imbalance of angiogenic\/antiangiogenic factors in massive perivillous fibrin deposition (maternal floor infarction): a placental lesion associated with recurrent miscarriage and fetal death","volume":"208","author":"Whitten","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib23","doi-asserted-by":"crossref","first-page":"212.e1","DOI":"10.1016\/j.ajog.2015.03.032","article-title":"Angiogenic markers in pregnancies conceived through in\u00a0vitro fertilization","volume":"213","author":"Lee","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib24","doi-asserted-by":"crossref","first-page":"247.e1","DOI":"10.1016\/j.ajog.2014.03.020","article-title":"The association of body mass index with serum angiogenic markers in normal and abnormal pregnancies","volume":"211","author":"Zera","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib25","doi-asserted-by":"crossref","first-page":"141.e1","DOI":"10.1016\/j.ajog.2013.09.022","article-title":"Circulating angiogenic factors in monochorionic twin pregnancies complicated by twin to twin transfusion syndrome and selective intrauterine growth restriction","volume":"210","author":"Yinon","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib26","doi-asserted-by":"crossref","first-page":"68.e1","DOI":"10.1016\/j.ajog.2013.08.032","article-title":"Does soluble fms-like tyrosine kinase-1 regulate placental invasion? Insight from the invasive placenta","volume":"210","author":"McMahon","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib27","doi-asserted-by":"crossref","first-page":"509.e1","DOI":"10.1016\/j.ajog.2014.05.032","article-title":"Angiogenic and inflammatory biomarkers in midpregnancy and small-for-gestational-age outcomes in Tanzania","volume":"211","author":"Darling","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib28","doi-asserted-by":"crossref","first-page":"121.e1","DOI":"10.1016\/j.ajog.2013.04.009","article-title":"Maternal soluble fms-like tyrosine kinase-1, placental growth factor, plasminogen activator inhibitor-2, and folate concentrations and early fetal size: the Generation R study","volume":"209","author":"Bouwland-Both","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib29","doi-asserted-by":"crossref","first-page":"345.e1","DOI":"10.1016\/j.ajog.2013.11.012","article-title":"Angiopoietin 1 and 2 serum concentrations in first trimester of pregnancy as\u00a0biomarkers of adverse pregnancy outcomes","volume":"210","author":"Schneuer","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib30","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1530\/REP-09-0092","article-title":"Regulation of vascular growth and function in the human placenta","volume":"138","author":"Burton","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.ajog.2015.09.068_bib31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00003081-200606000-00005","article-title":"Fetal growth restriction: pathogenic mechanisms","volume":"49","author":"Maulik","year":"2006","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib32","series-title":"Intrauterine growth restriction. ACOG Practice bulletin no. 12","year":"2000"},{"key":"10.1016\/j.ajog.2015.09.068_bib33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/AOG.0b013e31819930b0","article-title":"Ultrasonography in pregnancy. Practice bulletin no. 101","volume":"113","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib34","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2353\/ajpath.2007.070528","article-title":"Oxidative stress, gene expression, and protein changes induced in the human placenta during labor","volume":"171","author":"Cindrova-Davies","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajog.2015.09.068_bib35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2431-3-6","article-title":"A\u00a0nearly continuous measure of birth weight for gestational age using a United States national reference","volume":"3","author":"Oken","year":"2003","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.ajog.2015.09.068_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.placenta.2004.07.003","article-title":"The correlation between sampling site and gene expression in the term human placenta","volume":"26","author":"Wyatt","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2015.09.068_bib37","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/gkp045","article-title":"Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data","volume":"37","author":"Ruijter","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajog.2015.09.068_bib38","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.ajog.2015.09.068_bib39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/dvdy.20148","article-title":"Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system","volume":"231","author":"Gerhardt","year":"2004","journal-title":"Dev Dyn"},{"key":"10.1016\/j.ajog.2015.09.068_bib40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000146886","article-title":"Fetal vasculogenesis and angiogenesis in human placental villi","volume":"136","author":"Demir","year":"1989","journal-title":"Acta Anat (Basel)"},{"key":"10.1016\/j.ajog.2015.09.068_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-0705.1993.03030219.x","article-title":"Hemodynamic interpretation of the arterial Doppler waveform","volume":"3","author":"Maulik","year":"1993","journal-title":"Ultrasound Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2015.09.068_bib42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0143-4004(84)80051-X","article-title":"Idiopathic intrauterine growth retardation: histomorphometry of the human placenta","volume":"5","author":"Teasdale","year":"1984","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2015.09.068_bib43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.placenta.2003.10.010","article-title":"Aspects of human fetoplacental vasculogenesis and angiogenesis, III: changes in complicated pregnancies","volume":"25","author":"Mayhew","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2015.09.068_bib44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0012-1606(87)90335-6","article-title":"Specific cell surface labels in the visual centers of Xenopus laevis tadpole identified using monoclonal antibodies","volume":"122","author":"Takagi","year":"1987","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajog.2015.09.068_bib45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0168-0102(93)90092-5","article-title":"The membrane protein A5, a putative neuronal recognition molecule, promotes neurite outgrowth","volume":"17","author":"Hirata","year":"1993","journal-title":"Neurosci Res"},{"key":"10.1016\/j.ajog.2015.09.068_bib46","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1242\/dev.121.12.4309","article-title":"Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs","volume":"121","author":"Kitsukawa","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ajog.2015.09.068_bib47","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1042\/BST20110697","article-title":"How neuropilin-1 regulates receptor tyrosine kinase signaling: the knowns and known unknowns","volume":"39","author":"Zachary","year":"2011","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.ajog.2015.09.068_bib48","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1242\/dev.103028","article-title":"Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis","volume":"141","author":"Fantin","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ajog.2015.09.068_bib49","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1128\/MCB.00903-10","article-title":"Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells","volume":"31","author":"Evans","year":"2011","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajog.2015.09.068_bib50","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.devcel.2013.03.019","article-title":"The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis","volume":"25","author":"Lanahan","year":"2013","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajog.2015.09.068_bib51","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4161\/mabs.1.4.8885","article-title":"Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration","volume":"1","author":"Lu","year":"2009","journal-title":"MAbs"},{"key":"10.1016\/j.ajog.2015.09.068_bib52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/geno.2000.6381","article-title":"Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms","volume":"70","author":"Rossignol","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.ajog.2015.09.068_bib53","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2015.09.068_bib54","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1526-968X(200003)26:3<213::AID-GENE7>3.0.CO;2-M","article-title":"Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation","volume":"26","author":"Halder","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.ajog.2015.09.068_bib55","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejogrb.2010.10.018","article-title":"Expression of the vascular endothelial growth factor receptor neuropilin-1 at the human embryo-maternal interface","volume":"154","author":"Baston-Buest","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2015.09.068_bib56","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1172\/JCI66966","article-title":"Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia","volume":"123","author":"Zhou","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2015.09.068_bib57","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.placenta.2014.10.002","article-title":"Placental SEMA3B expression is not altered in severe early onset preeclampsia","volume":"35","author":"Kaitu\u2019u-Lino","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2015.09.068_bib58","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/14767050802046069","article-title":"Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: soluble Tie-2","volume":"21","author":"Gotsch","year":"2008","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.09.068_bib59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/14767050701832833","article-title":"The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulation","volume":"21","author":"Chaiworapongsa","year":"2008","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.09.068_bib60","first-page":"1","article-title":"The use of angiogenic biomarkers in maternal blood to identify which SGA fetuses will require a preterm delivery and mothers who will develop pre-eclampsia","author":"Chaiworapongsa","year":"2015","journal-title":"J\u00a0Matern Fetal Neonatal Med"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815011199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815011199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:06:16Z","timestamp":1757588776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937815011199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0002937815011199"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2015.09.068","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of placental neuropilin-1 in fetal growth restriction","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2015.09.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The Authors. Published by Mosby, Inc.","name":"copyright","label":"Copyright"}]}}