{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:43:09Z","timestamp":1792626189300,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ajog.2015.09.101","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T12:43:38Z","timestamp":1444740218000},"page":"387.e1-387.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Urinary tract infection during pregnancy, angiogenic factor profiles, and risk of preeclampsia"],"prefix":"10.1016","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0150-3537","authenticated-orcid":false,"given":"Sarah Rae","family":"Easter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Cantonwine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe A.","family":"Zera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee-Hak","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel I.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"McElrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2015.09.101_bib1","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.101_bib2","first-page":"1260","volume":"356","author":"Walker","year":"2000","journal-title":"Pre-eclampsia. Lancet"},{"key":"10.1016\/j.ajog.2015.09.101_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0146-0005(03)00022-3","article-title":"What we have learned about preeclampsia","volume":"27","author":"Sibai","year":"2003","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajog.2015.09.101_bib4","doi-asserted-by":"crossref","first-page":"e91198","DOI":"10.1371\/journal.pone.0091198","article-title":"Risk factors of pre-eclampsia\/eclampsia and its adverse outcomes in low- and middle-income countries: a WHO secondary analysis","volume":"9","author":"Bilano","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2015.09.101_bib5","first-page":"631","volume":"376","author":"Steegers","year":"2010","journal-title":"Pre-eclampsia. Lancet"},{"key":"10.1016\/j.ajog.2015.09.101_bib6","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ajog.2015.09.101_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajog.2007.07.040","article-title":"Maternal infection and risk of preeclampsia: systematic review and metaanalysis","volume":"198","author":"Conde-Agudelo","year":"2008","journal-title":"Am J\u00a0Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.101_bib8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/QAI.0b013e318286d77e","article-title":"High viral load and elevated angiogenic markers associated with increased risk of preeclampsia among women initiating highly active antiretroviral therapy in pregnancy in the Mma Bana Study, Botswana","volume":"62","author":"Powis","year":"2013","journal-title":"J\u00a0Acquir Immune Defic Syndr"},{"key":"10.1016\/j.ajog.2015.09.101_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.preghy.2013.03.002","article-title":"Prenatal Chlamydia trachomatis infection increases the risk of preeclampsia","volume":"3","author":"Haggerty","year":"2013","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ajog.2015.09.101_bib10","first-page":"CD000490","article-title":"Antibiotics for asymptomatic bacteriuria in pregnancy","volume":"8","author":"Smaill","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajog.2015.09.101_bib11","first-page":"224","article-title":"Asymptomatic bacteriuria in pregnancy and its association with prematurity","volume":"63","author":"Bryant","year":"1964","journal-title":"J\u00a0Lab Clin Med"},{"key":"10.1016\/j.ajog.2015.09.101_bib12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0002-9378(64)90784-7","article-title":"The significance of asymptomatic bacteriuria in the normal obstetric patient","volume":"90","author":"Low","year":"1964","journal-title":"Am J\u00a0Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.101_bib13","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0140-6736(66)90534-4","article-title":"The incidence of urinary infection in 5000 pregnant women","volume":"2","author":"Little","year":"1966","journal-title":"Lancet"},{"issue":"Suppl","key":"10.1016\/j.ajog.2015.09.101_bib14","first-page":"S113","article-title":"The effects of bacteriuria in pregnancy on maternal and fetal health","volume":"4","author":"Brumfitt","year":"1975","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajog.2015.09.101_bib15","first-page":"12","article-title":"Bacteriuria and pregnancy outcome: a prospective hospital-based study in Pakistani women","volume":"44","author":"Qureshi","year":"1994","journal-title":"J\u00a0Pak Med Assoc"},{"key":"10.1016\/j.ajog.2015.09.101_bib16","doi-asserted-by":"crossref","first-page":"407.e1","DOI":"10.1016\/j.ajog.2012.08.010","article-title":"Longitudinal evaluation of predictive value for preeclampsia of circulating angiogenic factors through pregnancy","volume":"207","author":"McElrath","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.101_bib17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.09.101_bib18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2015.09.101_bib19","doi-asserted-by":"crossref","first-page":"e73047","DOI":"10.1371\/journal.pone.0073047","article-title":"Acute maternal infection and risk of pre-eclampsia: a population-based case-control study","volume":"8","author":"Minassian","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2015.09.101_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00404-008-0643-2","article-title":"The relationship between urinary tract infection during pregnancy and preeclampsia: causal, confounded or spurious?","volume":"277","author":"Karmon","year":"2008","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ajog.2015.09.101_bib21","first-page":"491","article-title":"Pre-eclampsia: a nested, case-control study of risk factors and their interactions","volume":"41","author":"Mittendorf","year":"1996","journal-title":"J\u00a0Reprod Med"},{"key":"10.1016\/j.ajog.2015.09.101_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0020-7292(95)02373-K","article-title":"Urogenital infection in preeclampsia","volume":"49","author":"Hsu","year":"1995","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajog.2015.09.101_bib23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/14767050903067378","article-title":"Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasma","volume":"23","author":"Chaiworapongsa","year":"2010","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.09.101_bib24","doi-asserted-by":"crossref","first-page":"e24985","DOI":"10.1371\/journal.pone.0024985","article-title":"Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi and associations with placental malaria and fetal growth restriction","volume":"6","author":"Silver","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2015.09.101_bib25","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1056\/NEJMc052721","article-title":"Elevated sFlt1 level and preeclampsia with parvovirus-induced hydrops","volume":"354","author":"Stephan","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.09.101_bib26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/01.AOG.0000248538.03280.cf","article-title":"Cytomegalovirus-induced mirror syndrome associated with elevated levels of circulating antiangiogenic factors","volume":"109","author":"Rana","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.09.101_bib27","doi-asserted-by":"crossref","first-page":"G648","DOI":"10.1152\/ajpgi.00466.2005","article-title":"VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease","volume":"290","author":"Goebel","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ajog.2015.09.101_bib28","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1096\/fj.03-1476fje","article-title":"A\u00a0central role for inflammation in the pathogenesis of diabetic retinopathy","volume":"18","author":"Joussen","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.ajog.2015.09.101_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/10641955.2013.784788","article-title":"Clinical characterization and outcomes of preeclampsia with normal angiogenic profile","volume":"32","author":"Rana","year":"2013","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.ajog.2015.09.101_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1161\/HYPERTENSIONAHA.112.191213","article-title":"Low placental growth factor across pregnancy identifies a subset of women with preterm preeclampsia: type 1 versus type 2 preeclampsia?","volume":"60","author":"Powers","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2015.09.101_bib31","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1001\/jama.287.20.2701","article-title":"Does this woman have an acute uncomplicated urinary tract infection?","volume":"287","author":"Bent","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2015.09.101_bib32","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1001\/jama.2014.12842","article-title":"Diagnosis and management of urinary tract infections in the outpatient setting: a review","volume":"312","author":"Grigoryan","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2015.09.101_bib33","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/ajcp\/96.5.582","article-title":"The diagnostic accuracy of rapid dipstick tests to predict urinary tract infection","volume":"96","author":"Hurlbut","year":"1991","journal-title":"Am J Clin Pathol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815012156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815012156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:06:55Z","timestamp":1757588815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937815012156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0002937815012156"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2015.09.101","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary tract infection during pregnancy, angiogenic factor profiles, and risk of preeclampsia","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2015.09.101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}