{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:08:16Z","timestamp":1791608896764,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.ajog.2015.11.039","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T02:06:50Z","timestamp":1450231610000},"page":"649.e1-649.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":227,"title":["Exercise during pregnancy protects against hypertension and\u00a0macrosomia: randomized clinical trial"],"prefix":"10.1016","volume":"214","author":[{"given":"Ruben","family":"Barakat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Pelaez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6909-8857","authenticated-orcid":false,"given":"Yaiza","family":"Cordero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Perales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Coteron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle F.","family":"Mottola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2015.11.039_bib1","first-page":"105918","article-title":"A\u00a0comprehensive review of hypertension in pregnancy","volume":"2012","author":"Mustafa","year":"2012","journal-title":"J\u00a0Pregnancy"},{"key":"10.1016\/j.ajog.2015.11.039_bib2","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","article-title":"Hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.11.039_bib3","first-page":"132","article-title":"Epidemiolog\u00eda de los estados hipertensivos del embarazo","volume":"36","author":"Cort\u00e9s P\u00e9rez","year":"2009","journal-title":"Clin Invest Ginecol Obstet"},{"key":"10.1016\/j.ajog.2015.11.039_bib4","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1093\/eurheartj\/ehr218","article-title":"ESC guidelines on the management of cardiovascular diseases during pregnancy","volume":"32","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ajog.2015.11.039_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijcard.2003.10.028","article-title":"Pregnancy and the cardiovascular system","volume":"98","author":"Abbas","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ajog.2015.11.039_bib6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s11906-011-0214-y","article-title":"Mechanisms and management of hypertension in pregnant women","volume":"13","author":"Brown","year":"2011","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.ajog.2015.11.039_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1053\/plac.2002.0819","article-title":"Recent insights into the pathogenesis of pre-eclampsia","volume":"23","author":"Roberts","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2015.11.039_bib8","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3109\/14767058.2014.939624","article-title":"Excessive weight gain and hypertensive disorders of pregnancy in the obese patient","volume":"28","author":"Chandrasekaran","year":"2015","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.11.039_bib9","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/01.EDE.0000059921.71494.D1","article-title":"Maternal body mass index and the risk of preeclampsia: a systematic overview","volume":"14","author":"O\u2019Brien","year":"2003","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajog.2015.11.039_bib10","first-page":"397","article-title":"Study on the influence of pregnancy-induced hypertension on neonatal birth weight and its interaction with other factors","volume":"35","author":"He","year":"2014","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"10.1016\/j.ajog.2015.11.039_bib11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/03014460.2013.793390","article-title":"Impact of risk factors on hypertensive disorders in pregnancy, in primiparae and multiparae","volume":"40","author":"Alves","year":"2013","journal-title":"Ann Hum Biol"},{"key":"10.1016\/j.ajog.2015.11.039_bib12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1523-536X.2010.00407.x","article-title":"Physical activity and hypertensive complications during pregnancy: findings from 2004 to 2006 North Carolina Pregnancy Risk Assessment Monitoring System","volume":"37","author":"Martin","year":"2010","journal-title":"Birth"},{"key":"10.1016\/j.ajog.2015.11.039_bib13","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/01.HYP.0000072270.82815.91","article-title":"Recreational physical activity during pregnancy and risk of preeclampsia","volume":"41","author":"Sorensen","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2015.11.039_bib14","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/aje\/kwh277","article-title":"Work, leisure-time physical activity, and risk of preeclampsia and gestational hypertension","volume":"160","author":"Saftlas","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajog.2015.11.039_bib15","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1249\/MSS.0b013e31817cab1","article-title":"A\u00a0prospective analysis of recreational physical activity and preeclampsia risk","volume":"40","author":"Rudra","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.ajog.2015.11.039_bib16","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/HYPERTENSIONAHA.112.194050","article-title":"Impact of exercise training on preeclampsia: potential preventive mechanisms","volume":"60","author":"Genest","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2015.11.039_bib17","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1600-0412.2012.01483.x","article-title":"Exercise and physical activity in the prevention of pre-eclampsia: systematic review","volume":"91","author":"Kasawara","year":"2012","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"10.1016\/j.ajog.2015.11.039_bib18","first-page":"CD005942","article-title":"Exercise or other physical activity for preventing preeclampsia and its complications (review)","author":"Meher","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajog.2015.11.039_bib19","first-page":"171","article-title":"Exercise during pregnancy and the postpartum period. ACOG Committee opinion no. 267, January 2002 (reaffirmed 2009)","volume":"99","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.11.039_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/bjsm.26.2.121","article-title":"Accuracy of Borg's ratings of perceived exertion in the prediction of heart rates during pregnancy","volume":"26","author":"O'Neill","year":"1992","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.ajog.2015.11.039_bib21","series-title":"Weight gain during pregnancy: reexamining the guidelines","year":"2009"},{"key":"10.1016\/j.ajog.2015.11.039_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/sj.jp.7210754","article-title":"Neonatal anthropometric measurements to predict birth weight by ultrasound","volume":"22","author":"Stetzer","year":"2002","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.ajog.2015.11.039_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1001\/jama.1994.03520020048013","article-title":"Statistical power, sample size, and their reporting in randomized controlled trials","volume":"272","author":"Moher","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2015.11.039_bib24","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0140-6736(05)61034-3","article-title":"Sample size calculations in randomized trials: mandatory and mystical","volume":"365","author":"Schulz","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2015.11.039_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1547-5069.2010.01344.x","article-title":"Prenatal stretching exercise and autonomic responses: preliminary data and a model for reducing preeclampsia","volume":"42","author":"Yeo","year":"2010","journal-title":"J\u00a0Nurs Scholarsh"},{"key":"10.1016\/j.ajog.2015.11.039_bib26","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1055\/s-0032-1304635","article-title":"Walking program of low or vigorous intensity during pregnancy confers an aerobic benefit","volume":"33","author":"Ruchat","year":"2012","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.ajog.2015.11.039_bib27","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1097\/HJH.0b013e32833e97d0","article-title":"Exercise training can attenuate preeclampsia-like features in an animal model","volume":"28","author":"Falcao","year":"2010","journal-title":"J\u00a0Hypertension"},{"key":"10.1016\/j.ajog.2015.11.039_bib28","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1249\/MSS.0b013e31825365f1","article-title":"Nutrition and exercise reduce excessive weight gain in normal weight pregnant women","volume":"44","author":"Ruchat","year":"2012","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.ajog.2015.11.039_bib29","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.mayocp.2013.07.020","article-title":"Supervised exercise-based intervention to prevent excessive gestational weight gain: a randomized controlled trial","volume":"88","author":"Ruiz","year":"2013","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ajog.2015.11.039_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1249\/MSS.0b013e3181b5419a","article-title":"Nutrition and exercise prevents excess weight gain in pregnant overweight women","volume":"42","author":"Mottola","year":"2010","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.ajog.2015.11.039_bib31","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.3109\/14767058.2012.696165","article-title":"Exercise during pregnancy reduces\u00a0the rate of cesarean and instrumental deliveries: results of a randomized controlled trial","volume":"25","author":"Barakat","year":"2012","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.11.039_bib32","first-page":"103","article-title":"Effect of a single bout of exercise on the mood of pregnant women","volume":"47","author":"Polman","year":"2007","journal-title":"J\u00a0Sports Med Phys Fitness"},{"key":"10.1016\/j.ajog.2015.11.039_bib33","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1249\/01.mss.0000174907.27818.ff","article-title":"Physical activity and mood during pregnancy","volume":"37","author":"Poudevigne","year":"2005","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.ajog.2015.11.039_bib34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/OGX.0b013e318242030e","article-title":"The potential impact of physical activity during pregnancy on maternal and neonatal outcomes","volume":"67","author":"Ferraro","year":"2012","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.ajog.2015.11.039_bib35","doi-asserted-by":"crossref","first-page":"402.e1","DOI":"10.1016\/j.ajog.2011.01.043","article-title":"Exercise during pregnancy improves maternal health perception: a randomized controlled trial","volume":"204","author":"Barakat","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.11.039_bib36","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1249\/MSS.0b013e318247b324","article-title":"Regular maternal exercise dose and fetal heart outcome","volume":"44","author":"May","year":"2012","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.ajog.2015.11.039_bib37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/aje\/kwp101","article-title":"Associations of gestational weight gain with short- and longer-term maternal and child health outcomes","volume":"170","author":"Oken","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajog.2015.11.039_bib38","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1111\/j.1753-4887.2004.tb00079.x","article-title":"Pregnancy-related weight gain\u2013a link to obesity?","volume":"62","author":"Seiga-Riz","year":"2004","journal-title":"Nutr Rev"},{"key":"10.1016\/j.ajog.2015.11.039_bib39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/ijo.2009.206","article-title":"Gestational weight gain in relation to offspring body mass index and obesity from infancy through adulthood","volume":"34","author":"Schack-Neilsen","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.ajog.2015.11.039_bib40","first-page":"470247","article-title":"Preventing long-term risk of obesity for two generations: prenatal physical activity is part of the puzzle","volume":"2012","author":"Ruchat","year":"2012","journal-title":"J\u00a0Pregnancy"},{"key":"10.1016\/j.ajog.2015.11.039_bib41","first-page":"11","article-title":"The developmental origins of obesity and related health disorders\u2013prenatal and perinatal factors","volume":"31","author":"Benyshek","year":"2007","journal-title":"Coll Antropol"},{"key":"10.1016\/j.ajog.2015.11.039_bib42","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-3016.2010.01177.x","article-title":"Psychosocial work stress during pregnancy and birthweight","volume":"25","author":"Lee","year":"2011","journal-title":"Paediatr Perinat Epidemiol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815024795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815024795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:08:48Z","timestamp":1757588928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937815024795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0002937815024795"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2015.11.039","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise during pregnancy protects against hypertension and\u00a0macrosomia: randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2015.11.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}