{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:49:01Z","timestamp":1771364941990,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ajog.2015.12.025","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T02:15:24Z","timestamp":1450750524000},"page":"729.e1-729.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Chromosomal abnormalities not currently detected by cell-free fetal DNA: a retrospective analysis at a single center"],"prefix":"10.1016","volume":"214","author":[{"given":"Hagit","family":"Shani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Goldwaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Keating","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Klugman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2015.12.025_bib1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1056\/NEJMoa1407349","article-title":"Cell-free DNA analysis for noninvasive examination of trisomy","volume":"372","author":"Norton","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.12.025_bib2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/GIM.0b013e3182368a0e","article-title":"DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study","volume":"13","author":"Palomaki","year":"2011","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2015.12.025_bib3","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/AOG.0b013e31824fb482","article-title":"Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing","volume":"119","author":"Bianchi","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/uog.12504","article-title":"Implementation of maternal blood cell-free DNA testing in early screening for aneuploidies","volume":"42","author":"Gil","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib5","doi-asserted-by":"crossref","first-page":"319.e1","DOI":"10.1016\/j.ajog.2012.01.030","article-title":"Noninvasive prenatal detection and selective analysis of cell-free DNA obtained from maternal blood: evaluation for trisomy 21 and trisomy 18","volume":"206","author":"Sparks","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/pd.4103","article-title":"Validation of targeted sequencing of single-nucleotide polymorphisms for non-invasive prenatal detection of aneuploidy of chromosomes 13, 18, 21, X, and Y","volume":"33","author":"Nicolaides","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2015.12.025_bib7","doi-asserted-by":"crossref","first-page":"527.e1","DOI":"10.1016\/j.ajog.2014.08.006","article-title":"Clinical experience and follow-up with large scale single-nucleotide polymorphism-based noninvasive prenatal aneuploidy testing","volume":"211","author":"Dar","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1311037","article-title":"DNA sequencing versus standard prenatal aneuploidy screening","volume":"370","author":"Bianchi","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.12.025_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/gim.2011.73","article-title":"DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study","volume":"14","author":"Palomaki","year":"2012","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2015.12.025_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/uog.12299","article-title":"Trisomy 13 detection in the first trimester of pregnancy using a chromosome-selective cell-free DNA analysis method","volume":"41","author":"Ashoor","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib11","doi-asserted-by":"crossref","first-page":"137.e1","DOI":"10.1016\/j.ajog.2012.05.021","article-title":"Non-Invasive Chromosomal Evaluation (NICE) Study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18","volume":"207","author":"Norton","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib12","doi-asserted-by":"crossref","first-page":"374.e1","DOI":"10.1016\/j.ajog.2012.08.033","article-title":"Noninvasive prenatal testing for fetal trisomies in a routinely screened first-trimester population","volume":"207","author":"Nicolaides","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1755-8794-5-57","article-title":"Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies","volume":"5","author":"Jiang","year":"2012","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.ajog.2015.12.025_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000355655","article-title":"Prenatal detection of fetal triploidy from cell-free DNA testing in maternal blood","volume":"35","author":"Nicolaides","year":"2014","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ajog.2015.12.025_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/pd.4541","article-title":"Circulating cell free DNA testing: are some test failures informative?","volume":"35","author":"Palomaki","year":"2015","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2015.12.025_bib16","doi-asserted-by":"crossref","first-page":"79.e71","DOI":"10.1016\/j.ajog.2014.10.012","article-title":"Detection of triploid, molar, and vanishing twin\u00a0pregnancies by a single-nucleotide polymorphism-based noninvasive prenatal test","volume":"212","author":"Curnow","year":"2015","journal-title":"Am\u00a0J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib17","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/pd.4139","article-title":"Position statement from the Aneuploidy Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis","volume":"33","author":"Benn","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2015.12.025_bib18","unstructured":"Society for Maternal Fetal Medicine. SMFM Statement: maternal serum cell-free DNA screening in low risk women. SMFM statement maternal serum cell free DNA screening in low risk women. Available at: https:\/\/www.smfm.org\/publications\/157. Accessed: February 9, 2015."},{"key":"10.1016\/j.ajog.2015.12.025_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s10897-012-9545-3","article-title":"NSGC practice guideline: prenatal screening and diagnostic testing options for chromosome aneuploidy","volume":"22","author":"Wilson","year":"2013","journal-title":"J\u00a0Genet Couns"},{"key":"10.1016\/j.ajog.2015.12.025_bib20","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/01.AOG.0000423819.85283.f4","article-title":"Committee Opinion no.: 545. Noninvasive prenatal testing for fetal aneuploidy","volume":"120","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/uog.13393","article-title":"ISUOG consensus statement on the impact of non-invasive prenatal testing (NIPT) on prenatal ultrasound practice","volume":"44","author":"Salomon","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/gim.2013.29","article-title":"ACMG statement on noninvasive prenatal screening for fetal aneuploidy","volume":"15","author":"Gregg","year":"2013","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2015.12.025_bib23","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1097\/AOG.0000000000001051","article-title":"ACOG Committee Opinion no.: 640, September 2015. Cell-free DNA screening for fetal aneuploidy","volume":"126","year":"2015","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/uog.14636","article-title":"Procedure-related risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review and meta-analysis","volume":"45","author":"Akolekar","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib25","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1056\/NEJMoa1203382","article-title":"Chromosomal microarray versus karyotyping for prenatal diagnosis","volume":"367","author":"Wapner","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.12.025_bib26","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/pd.2802","article-title":"Detection rate of quadruple-marker screening determined by clinical follow-up and registry data in the statewide California program, July 2007 to February 2009","volume":"31","author":"Kazerouni","year":"2011","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2015.12.025_bib27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/pd.4054","article-title":"Nearly a third of abnormalities found after first-trimester screening are different than expected: 10-year experience from a single center","volume":"33","author":"Alamillo","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2015.12.025_bib28","first-page":"1459","article-title":"ACOG Practice Bulletin no.: 88, December 2007. Invasive prenatal testing for\u00a0aneuploidy","volume":"110","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib29","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1097\/01.AOG.0000438962.16108.d1","article-title":"Committee Opinion no.: 581. The use of chromosomal microarray analysis in prenatal diagnosis","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/uog.14791","article-title":"Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis","volume":"45","author":"Gil","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ajhg.2012.12.006","article-title":"Noninvasive detection of fetal subchromosome abnormalities via deep sequencing of maternal plasma","volume":"92","author":"Srinivasan","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajog.2015.12.025_bib32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/pd.4126","article-title":"The impact of maternal plasma DNA fetal fraction on next generation sequencing tests for common fetal aneuploidies","volume":"33","author":"Canick","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2015.12.025_bib33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/AOG.0000000000000363","article-title":"Single-nucleotide polymorphism-based noninvasive prenatal screening in a high-risk and low-risk cohort","volume":"124","author":"Pergament","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib34","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/uog.14792","article-title":"Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies","volume":"45","author":"Zhang h","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib35","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/AOG.0000000000000452","article-title":"Chromosome abnormalities detected by current prenatal screening and noninvasive prenatal testing","volume":"124","author":"Norton","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000381182","article-title":"Estimation of detection rates of aneuploidy in high-risk pregnancy using an approach based on nuchal translucency and non-invasive prenatal testing: a cohort study","volume":"38","author":"Khalil","year":"2015","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ajog.2015.12.025_bib37","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ejhg.2008.265","article-title":"Incidence of non-age-dependent chromosomal abnormalities: a population-based study on 88965 amniocenteses","volume":"17","author":"Forabosco","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ajog.2015.12.025_bib38","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3109\/14767058.2013.858243","article-title":"Clinical utility of chromosomal microarray analysis in prenatal diagnosis: report of first 6 months in clinical practice","volume":"27","author":"Klugman","year":"2014","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2015.12.025_bib39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/AOG.0000000000000336","article-title":"Association of copy number variants with specific ultrasonographically detected fetal anomalies","volume":"124","author":"Donnelly","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2015.12.025_bib40","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1097\/AOG.0000000000000874","article-title":"Cell-free DNA analysis in maternal plasma in cases of fetal abnormalities detected on ultrasound examination","volume":"125","author":"Benachi","year":"2015","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815025739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815025739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:07:38Z","timestamp":1757588858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937815025739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0002937815025739"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2015.12.025","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromosomal abnormalities not currently detected by cell-free fetal DNA: a retrospective analysis at a single center","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2015.12.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}