{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:50:45Z","timestamp":1784026245628,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ajog.2015.12.052","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T19:01:02Z","timestamp":1456599662000},"page":"385.e1-385.e7","source":"Crossref","is-referenced-by-count":43,"title":["Integrase inhibitors in late pregnancy and rapid HIV viral load reduction"],"prefix":"10.1016","volume":"214","author":[{"given":"Lisa","family":"Rahangdale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Cates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoNell","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina L.","family":"Badell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilly S.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenell S.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gweneth B.","family":"Lazenby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Levison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Short","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigal","family":"Yawetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciaranello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunthita","family":"Duthely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam H.","family":"Rimawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean R.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Stringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2015.12.052_bib1","unstructured":"Panel of Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. Available at: http:\/\/aidsinfo.nih.gov\/contentfiles\/lvguidelines\/PerinatalGL.pdf. Accessed Aug. 8,\u00a02015."},{"key":"10.1016\/j.ajog.2015.12.052_bib2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/QAD.0b013e3282f9b67a","article-title":"Low rates of mother-to-child transmission of HIV following effective pregnancy intervention in the United Kingdom and Ireland, 2000-2006","volume":"22","author":"Townsend","year":"2008","journal-title":"AIDS"},{"key":"10.1016\/j.ajog.2015.12.052_bib3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1542\/peds.2012-0194","article-title":"A\u00a0framework for elimination of perinatal transmission of HIV in the United States","volume":"130","author":"Neisham","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2015.12.052_bib4","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1056\/NEJM199411033311801","article-title":"Reduction of maternal-infant transmision of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group","volume":"331","author":"Connor","year":"1994","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2015.12.052_bib5","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1097\/QAD.0000000000000710","article-title":"Missed opportunities for prevention of mother-to-child transmission in the United States: a review of cases from the state of Georgia, 2005-2012","volume":"29","author":"Camacho-Gomez","year":"2015","journal-title":"AIDS"},{"key":"10.1016\/j.ajog.2015.12.052_bib6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.7326\/M13-2005","article-title":"Factors associated with lack of viral suppression at delivery among highly active antiretroviral therapy-naive women with HIV: a cohort study","volume":"162","author":"Katz","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajog.2015.12.052_bib7","unstructured":"Panel on Antiretroviral Guidelines for Adults\u00a0and Adolescents. Guidelines for the\u00a0use\u00a0of antiretroviral agents in HIV-1 infected\u00a0adults and adolescents. Available at: https:\/\/aidsinfo.nih.gov\/contentfiles\/lvguidelines\/adultandadolescentgl.pdf. Accessed Aug. 30,\u00a02015."},{"key":"10.1016\/j.ajog.2015.12.052_bib8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1089\/apc.2012.0283","article-title":"Rapid decline in HIV viral load when introducing raltegravir-containing antiretroviral treatment late in pregnancy","volume":"26","author":"Westling","year":"2012","journal-title":"AIDS Patient Care STDs"},{"key":"10.1016\/j.ajog.2015.12.052_bib9","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1089\/aid.2013.0059","article-title":"Short communication: use of raltegravir in late-presenting HIV-infected pregnant women","volume":"29","author":"Nobrega","year":"2013","journal-title":"AIDS Res Hum Retroviruses"},{"key":"10.1016\/j.ajog.2015.12.052_bib10","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/jpids\/pit019","article-title":"Salvage regimens containing darunavir, etravirine, raltegravir, or enfuvirtide in highly treatment-experience perinatally infected pregnant women","volume":"3","author":"Shust","year":"2014","journal-title":"J\u00a0Pediatric Infect Dis Soc"},{"key":"10.1016\/j.ajog.2015.12.052_bib11","article-title":"Five years' real-life experience with raltegravir in a large HIV center","author":"van Halsema","year":"2015","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.ajog.2015.12.052_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1155\/2015\/731043","article-title":"A\u00a0case series of third-trimester raltegravir initiation: impact on maternal HIV-1 viral load and obstetrical outcomes","volume":"26","author":"Boucoiran","year":"2015","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"10.1016\/j.ajog.2015.12.052_bib13","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/QAD.0b013e3283536a6c","article-title":"When should HAART be initiated in pregnancy to achieve an undetectable HIV viral load by delivery?","volume":"26","author":"Read","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.ajog.2015.12.052_bib14","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/1471-0528.12226","article-title":"Time to viral load suppression in antiretroviral-naive and -experienced HIV-infection pregnant women on highly active antiretroviral therapy: implications for pregnant women presenting late in gestation","volume":"120","author":"Aziz","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2015.12.052_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/QAI.0000000000000318","article-title":"Raltegravir pharmacokinetics during pregnancy","volume":"67","author":"Watts","year":"2014","journal-title":"J\u00a0Acquir Immune Defic Syndr"},{"key":"10.1016\/j.ajog.2015.12.052_bib16","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/cid\/civ366","article-title":"Raltegravir in HIV-1 infected pregnant women: pharmacokinetics, safety and efficacy","volume":"61","author":"Blonk","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2015.12.052_bib17","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1097\/QAD.0b013e32833d8a50","article-title":"High neonatal concentrations of raltegravir following transplacental transfer in HIV-1 positive pregnant women","volume":"24","author":"McKeown","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.ajog.2015.12.052_bib18","unstructured":"Antiretroviral Pregnancy Registry Steering Committee. Antiretroviral Pregnancy Registry international interim report for January 1, 1989 through January 31, 2015. Available at: http:\/\/www.APRegistry.com. Accessed July 13,\u00a02015."},{"key":"10.1016\/j.ajog.2015.12.052_bib19","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1258\/ijsa.2011.010469","article-title":"Raltegravir in pregnancy: a case series presentation","volume":"22","author":"Taylor","year":"2011","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.ajog.2015.12.052_bib20","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1093\/jac\/dkq264","article-title":"Rapid HIV-RNA decline following addition of raltegravir and tenofovir to ongoing highly active antiretroviral therapy in a women presenting with high-level HIV viremia at week 38 of pregnancy","volume":"65","author":"Pinnetti","year":"2010","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.ajog.2015.12.052_bib21","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3851\/IMP1558","article-title":"Use of newer antiretroviral agents, darunavir and etravirine, with or without raltegravir, in pregnancy: a report of two cases","volume":"15","author":"Jaworsky","year":"2010","journal-title":"Antivir Ther"},{"key":"10.1016\/j.ajog.2015.12.052_bib22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/2325957413488176","article-title":"Rapid reduction in HIV viral load in late pregnancy with raltegravir: a case report","volume":"12","author":"Cha","year":"2013","journal-title":"J\u00a0Int Assoc Provid AIDS Care"},{"key":"10.1016\/j.ajog.2015.12.052_bib23","first-page":"181","article-title":"Use of raltegravir in a late presenter HIV-1 woman in advanced gestational age: a case report and literature review","volume":"25","author":"DeHoffer","year":"2013","journal-title":"J\u00a0Chemother"},{"key":"10.1016\/j.ajog.2015.12.052_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1701-2163(15)31051-3","article-title":"Increase in transaminase levels following the use of raltegravir in a woman with a high HIV viral load at 35 weeks of pregnancy","volume":"35","author":"Renet","year":"2013","journal-title":"J\u00a0Obstet Gynaecol Can"},{"key":"10.1016\/j.ajog.2015.12.052_bib25","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S1473-3099(11)70196-7","article-title":"Raltegravir once daily or twice daily in previously untreated patients with HIV-1: a randomized, active-controlled phase 3 non-inferiority trial","volume":"11","author":"Eron","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ajog.2015.12.052_bib26","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/COH.0b013e328356e91c","article-title":"Pharmacology of HIV integrase inhibitors","volume":"7","author":"Adams","year":"2012","journal-title":"Curr Opin HIV AIDS"},{"key":"10.1016\/j.ajog.2015.12.052_bib27","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1128\/AAC.00173-15","article-title":"Pharmacokinetics of dolutegravir in a premature neonate after HIV treatment intensification during pregnancy","volume":"59","author":"Pain","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajog.2015.12.052_bib28","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/QAD.0000000000000212","article-title":"Earlier initiation of ART and further decline in mother-to-child HIV transmission rates, 2000-2011","volume":"28","author":"Townsend","year":"2014","journal-title":"AIDS"}],"updated-by":[{"DOI":"10.1016\/j.ajog.2016.05.021","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000}}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815026563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937815026563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T15:31:22Z","timestamp":1654443082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937815026563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0002937815026563"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2015.12.052","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}