{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:04:56Z","timestamp":1791216296653,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["0313174"],"award-info":[{"award-number":["0313174"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ajog.2016.01.181","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T12:02:11Z","timestamp":1454068931000},"page":"96.e1-96.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Cytokines in noninvasively obtained amniotic fluid as predictors of fetal inflammatory response syndrome"],"prefix":"10.1016","volume":"215","author":[{"given":"Mirjam","family":"Kunze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Klar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Morfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beena","family":"Thorns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf L.","family":"Schild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz","family":"Markfeld-Erol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Rasenack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Proempeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Hentschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-1178","authenticated-orcid":false,"given":"Wolfgang R.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2016.01.181_bib1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0002-9378(98)70272-8","article-title":"The fetal inflammatory response syndrome","author":"Gomez","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/GRF.0b013e31811ebef6","article-title":"The fetal inflammatory response syndrome","volume":"50","author":"Gotsch","year":"2007","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0002-9378(93)90014-A","article-title":"A\u00a0comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes","volume":"169","author":"Romero","year":"1993","journal-title":"Am J\u00a0Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/jmf.11.1.18.25","article-title":"Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome","volume":"11","author":"Pacora","year":"2002","journal-title":"Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/00003081-199112000-00013","article-title":"Microbial invasion of the amniotic cavity in premature rupture of membranes","volume":"34","author":"Romero","year":"1991","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib6","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1067\/mob.2000.108888","article-title":"Histologic inflammation in the maternal and fetal compartments in a rabbit model of acute intra-amniotic infection","volume":"183","author":"Davies","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib7","first-page":"265","article-title":"The fetal inflammatory response syndrome is a risk factor for morbidity in preterm neonates","volume":"70","author":"Hofer","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2016.01.181_bib8","doi-asserted-by":"crossref","first-page":"e79941","DOI":"10.1371\/journal.pone.0079941","article-title":"Acute histologic chorioamnionitis is a risk factor for adverse neonatal outcome in late preterm birth after preterm premature rupture of membranes","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2016.01.181_bib9","first-page":"178","article-title":"Preterm premature rupture of membranes","volume":"10","author":"Mercer","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0002-9378(98)70271-6","article-title":"A\u00a0systemic inflammatory response is followed by\u00a0spontaneous onset of preterm parturition","volume":"179","author":"Romero","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cyto.2008.06.009","article-title":"Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection","volume":"44","author":"Chow","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.ajog.2016.01.181_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0020-7292(02)00016-4","article-title":"Interleukin-6 and interleukin-1 receptor antagonist in amniotic fluid and cord blood in patients with pre-term, premature rupture of membranes","volume":"77","author":"Fukada","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajog.2016.01.181_bib13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3109\/14767058.2013.844123","article-title":"The diagnostic performance of the Mass Restricted (MR) score in the identification of microbial invasion of the amniotic cavity or intra-amniotic inflammation is not superior to amniotic fluid interleukin-6","volume":"27","author":"Romero","year":"2014","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib14","doi-asserted-by":"crossref","first-page":"385.e1","DOI":"10.1016\/j.ajog.2014.03.069","article-title":"Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes","volume":"211","author":"Kacerovsky","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib15","first-page":"1","article-title":"A\u00a0point of care test for interleukin-6 in amniotic fluid in preterm prelabor rupture of membranes: a step toward the early treatment of acute intra-amniotic inflammation\/infection","volume":"23","author":"Chaemsaithong","year":"2015","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ajog.2015.05.039","article-title":"Detection of intraamniotic inflammation in fresh and processed amniotic fluid samples with the interleukin-6 point of care test","volume":"213","author":"Kacerovsky","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib17","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3109\/14767058.2013.829814","article-title":"Rapid evaluation of the absence of inflammation after rupture of membranes","volume":"27","author":"Berthiaume","year":"2014","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3109\/14767058.2014.917625","article-title":"Vaginal fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor membrane ruptures","volume":"28","author":"Kacerovsky","year":"2015","journal-title":"Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/aogs.12073","article-title":"Predictive value of combined cervicovaginal cytokines and gestational age at sampling for intra-amniotic infection in preterm premature rupture of membranes","volume":"92","author":"Ryu","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2016.01.181_bib20","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1067\/mob.2000.109035","article-title":"The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis","volume":"183","author":"Yoon","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/01.AOG.0000250474.35369.12","article-title":"Maternal serum cytokines in preterm premature rupture of membranes","volume":"109","author":"Murtha","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/aji.12323","article-title":"Changes in\u00a0maternal blood inflammatory markers as a predictor of chorioamnionitis: a prospective multicenter study","volume":"73","author":"Le Ray","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2016.01.181_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejogrb.2009.09.017","article-title":"Accuracy of C-reactive protein determination in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes: a systematic review","volume":"147","author":"Van de Laar","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2016.01.181_bib24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cyto.2015.04.014","article-title":"Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis","volume":"76","author":"Dulay","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.ajog.2016.01.181_bib25","doi-asserted-by":"crossref","first-page":"145.e1","DOI":"10.1016\/j.ajog.2011.08.028","article-title":"The antibiotic treatment of PPROM study: systemic maternal and fetal markers and perinatal outcomes","volume":"206","author":"Mercer","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2004.03.026","article-title":"Management of clinical chorioamnionitis at term","volume":"191","author":"Gibbs","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib27","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/AOG.0b013e3182351b0c","article-title":"Intrapartum management of premature rupture of membranes: effect on cesarean delivery rate","volume":"118","author":"Kunze","year":"2011","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.siny.2006.02.011","article-title":"Inflammatory responses in the placenta and umbilical cord","volume":"11","author":"Redline","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.siny.2011.08.003","article-title":"Inflammatory response in acute chorioamnionitis","volume":"17","author":"Redline","year":"2012","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib30","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1067\/mob.2003.380","article-title":"Components of the systemic fetal inflammatory response syndrome as predictors of impaired neurologic outcomes in children","volume":"188","author":"Mittendorf","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib31","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3109\/14767058.2014.927426","article-title":"Acute funisitis is associated with distinct changes in\u00a0fetal hematologic profile","volume":"28","author":"Kim","year":"2015","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000047130","article-title":"Cord blood levels of interleukin-6 and interleukin-8 for the immediate diagnosis of early-onset infection in premature infants","volume":"80","author":"Krueger","year":"2001","journal-title":"Biol Neonate"},{"key":"10.1016\/j.ajog.2016.01.181_bib33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1203\/00006450-199810000-00002","article-title":"Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis","volume":"44","author":"Berner","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajog.2016.01.181_bib34","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/jpids\/piu063","article-title":"Effective biomarkers for diagnosis of neonatal sepsis","volume":"3","author":"Bhandari","year":"2014","journal-title":"J\u00a0Ped Infect Dis"},{"key":"10.1016\/j.ajog.2016.01.181_bib35","doi-asserted-by":"crossref","first-page":"450.e1","DOI":"10.1016\/j.ajog.2013.12.024","article-title":"Prenatal inflammation is associated with adverse neonatal outcomes","volume":"210","author":"Bastek","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib36","doi-asserted-by":"crossref","first-page":"215.e1","DOI":"10.1016\/j.ajog.2014.09.005","article-title":"Outcomes of expectantly managed pregnancies with multiple gestations and preterm premature rupture of membranes prior to 26 weeks","volume":"212","author":"Wong","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1056\/NEJM197802022980519","article-title":"Neonatal necrotizing enterocolitis","volume":"298","author":"Bell","year":"1978","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weight less than 1500g","volume":"92","author":"Papile","year":"1978","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ajog.2016.01.181_bib39","first-page":"918","article-title":"ACOG Practice Bulletin No. 139: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists","volume":"139","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib40","doi-asserted-by":"crossref","first-page":"e0133929","DOI":"10.1371\/journal.pone.0133929","article-title":"Intraamniotic inflammation in women with preterm prelabor rupture of membranes","volume":"10","author":"Musilova","year":"201524","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2016.01.181_bib41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3109\/14767058.2014.908179","article-title":"Cervical fluid IL-6 and IL-8 levels in pregnancies complicated by preterm prelabor rupture of membranes","volume":"28","author":"Kacerovsky","year":"2015","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ajog.2004.07.015","article-title":"Detection of interleukin-6 in vaginal secretions of women with preterm premature rupture of membranes and its association with neonatal infection: a rapid immunochromatographic test","volume":"192","author":"Kayem","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib43","first-page":"1","article-title":"A\u00a0rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes","volume":"23","author":"Chaemsaithong","year":"2015","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib44","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3109\/14767058.2014.961417","article-title":"A\u00a0point of care test for the determination of amniotic fluid interleukin-6 and the chemokine CXCL-10\/IP-10","volume":"28","author":"Chaemsaithong","year":"2015","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2016.01.181_bib45","doi-asserted-by":"crossref","first-page":"408.e1","DOI":"10.1016\/j.ajog.2009.06.070","article-title":"A\u00a0novel method for collecting vaginal pool for fetal lung\u00a0maturity studies","volume":"201","author":"Gleaton","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.01.181_bib46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0020-7292(02)00238-2","article-title":"Maternal serum and amniotic fluid cytokines in patients with preterm premature rupture of membranes with and without intrauterine infection","volume":"79","author":"Shobokshi","year":"2002","journal-title":"Int J Gynaecol Obstet"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937816002313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937816002313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:09:28Z","timestamp":1757588968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937816002313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0002937816002313"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2016.01.181","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokines in noninvasively obtained amniotic fluid as predictors of fetal inflammatory response syndrome","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2016.01.181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}