{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:50:09Z","timestamp":1780721409564,"version":"3.54.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ajog.2016.03.003","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T02:32:48Z","timestamp":1457577168000},"page":"82.e1-82.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"title":["Validation of a second-generation multivariate index assay for\u00a0malignancy risk of adnexal masses"],"prefix":"10.1016","volume":"215","author":[{"given":"Robert L.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald G.","family":"Munroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd C.","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2016.03.003_bib1","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.3747\/co.19.980","article-title":"Management of a suspicious adnexal mass: a clinical practice guideline","volume":"19","author":"Dodge","year":"2012","journal-title":"Curr Oncol"},{"key":"10.1016\/j.ajog.2016.03.003_bib2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/AOG.0b013e31821477db","article-title":"The role of the generalist obstetrician gynecologist in the early detection of epithelial ovarian cancer. ACOG Committee opinion no. 280","volume":"117","year":"2011","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib3","first-page":"1413","article-title":"The role of the generalist obstetrician gynecologist in the early detection of ovarian cancer. ACOG Committee opinion no. 280","volume":"100","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib4","first-page":"568","article-title":"Misstaging of ovarian cancer","volume":"65","author":"McGowan","year":"1985","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib5","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ygyno.2005.07.008","article-title":"Who should operate on patients with ovarian cancer? An evidence-based review","volume":"99","author":"Giede","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2016.03.003_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1006\/gyno.2001.6460","article-title":"A\u00a0population-based study of patterns of care for ovarian cancer: who is seen by a gynecologic oncologist and who is not?","volume":"84","author":"Carney","year":"2002","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2016.03.003_bib7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1097\/AOG.0b013e31821b5118","article-title":"Effectiveness of a multivariate index assay in the preoperative assessment of ovarian tumors","volume":"117","author":"Ueland","year":"2011","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ygyno.2012.11.022","article-title":"Ovarian malignancy risk stratification of the adnexal mass using a multivariate index assay","volume":"128","author":"Bristow","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2016.03.003_bib9","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/01.AOG.0000267198.25223.bc","article-title":"How relevant are ACOG and SGO guidelines for referral of adnexal mass?","volume":"110","author":"Dearking","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib10","doi-asserted-by":"crossref","first-page":"581.e1","DOI":"10.1016\/j.ajog.2013.08.009","article-title":"Impact\u00a0of a multivariate index assay on referral patterns for surgical management of an adnexal mass","volume":"209","author":"Bristow","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib11","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1158\/0008-5472.CAN-04-0746","article-title":"Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2016.03.003_bib12","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1158\/1055-9965.EPI-10-0580","article-title":"The road from discovery to clinical diagnostics: lessons learned from the first FDA-cleared in\u00a0vitro diagnostic multivariate index assay of proteomic biomarkers","volume":"19","author":"Zhang","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ajog.2016.03.003_bib13","series-title":"Methods of microarray data analysis","article-title":"Applying classification separability analysis to microarray data","author":"Zhang","year":"2001"},{"key":"10.1016\/j.ajog.2016.03.003_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/01621459.1927.10502953","article-title":"Probable inference, the law of succession, and statistical inference","volume":"22","author":"Wilson","year":"1927","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.ajog.2016.03.003_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1191\/1740774506cn147oa","article-title":"Comparing the predictive values of diagnostic tests: sample size and analysis for paired study designs","volume":"3","author":"Moskowitz","year":"2006","journal-title":"Clin Trials"},{"key":"10.1016\/j.ajog.2016.03.003_bib16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.ajog.2016.03.003_bib17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1373\/clinchem.2012.185140","article-title":"The early detection research network\u2019s specimen reference sets: paving the way for rapid evaluation of potential biomarkers","volume":"59","author":"Feng","year":"2013","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2016.03.003_bib18","doi-asserted-by":"crossref","first-page":"78.e1","DOI":"10.1016\/j.ajog.2013.09.017","article-title":"Clinical performance of a multivariate index assay for detecting early-stage ovarian cancer","volume":"210","author":"Longoria","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib19","series-title":"Cancer facts and figures\u00a02015","year":"2015"},{"key":"10.1016\/j.ajog.2016.03.003_bib20","series-title":"SGO position statement. Multiplex serum testing for women with pelvic mass","year":"2013"},{"key":"10.1016\/j.ajog.2016.03.003_bib21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/uog.7636","article-title":"Ovarian cancer prediction in adnexal masses using ultrasound-based logistic regression models: a temporal and external validation study by the IOTA group","volume":"36","author":"Timmerman","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib22","doi-asserted-by":"crossref","first-page":"65.e1","DOI":"10.1016\/j.ajog.2014.02.010","article-title":"The effect of ovarian imaging on the clinical interpretation of a multivariate index assay","volume":"211","author":"Goodrich","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.03.003_bib23","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1136\/ijgc-00009577-200309000-00015","article-title":"FIGO stage IIIC endometrial carcinoma: resection of macroscopic nodal disease and other determinants of survival","volume":"13","author":"Bristow","year":"2003","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ajog.2016.03.003_bib24","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1002\/cncr.22604","article-title":"Predictors of comprehensive surgical treatment in patients with ovarian cancer","volume":"109","author":"Goff","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.ajog.2016.03.003_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ygyno.2010.05.025","article-title":"The National Cancer Database report on advanced-stage epithelial ovarian cancer: impact of hospital surgical case volume on overall survival and surgical treatment paradigm","volume":"118","author":"Bristow","year":"2010","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2016.03.003_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ygyno.2009.12.033","article-title":"Quality of care in advanced ovarian cancer: the importance of provider specialty","volume":"117","author":"Mercado","year":"2010","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2016.03.003_bib27","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1097\/AOG.0b013e3182922a17","article-title":"Adherence to treatment guidelines for ovarian cancer as a measure of quality care","volume":"121","author":"Bristow","year":"2013","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937816004658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937816004658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:10:39Z","timestamp":1757589039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937816004658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0002937816004658"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2016.03.003","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of a second-generation multivariate index assay for\u00a0malignancy risk of adnexal masses","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2016.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}