{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:46:30Z","timestamp":1758041190955,"version":"3.44.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.ajog.2016.06.046","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T20:16:36Z","timestamp":1477426596000},"page":"583-587.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Where have all the trisomies gone?"],"prefix":"10.1016","volume":"215","author":[{"given":"Glenn E.","family":"Palomaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geralyn M.","family":"Lambert-Messerlian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Haddow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2016.06.046_bib1","doi-asserted-by":"crossref","first-page":"727.e1","DOI":"10.1016\/j.ajog.2015.12.018","article-title":"Cell free DNA versus sequential screening for the detection of fetal chromosomal abnormalities","volume":"214","author":"Norton","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.06.046_bib2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/AOG.0000000000001040","article-title":"Detection rates for aneuploidy by first-trimester and sequential screening","volume":"126","author":"Baer","year":"2015","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.06.046_bib3","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/AOG.0000000000000452","article-title":"Chromosome abnormalities detected by current prenatal screening and noninvasive prenatal testing","volume":"124","author":"Norton","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.06.046_bib4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0140-6736(97)11280-6","article-title":"UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group","volume":"352","author":"Snijders","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2016.06.046_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/096914139600300105","article-title":"Can reliable Down's syndrome detection rates be determined from prenatal screening intervention trials?","volume":"3","author":"Palomaki","year":"1996","journal-title":"J\u00a0Med Screen"},{"key":"10.1016\/j.ajog.2016.06.046_bib6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0140-6736(98)22031-9","article-title":"Antenatal screening for Down's syndrome: where are we and where next?","volume":"352","author":"Haddow","year":"1998","journal-title":"Lancet"},{"issue":"Pt 1","key":"10.1016\/j.ajog.2016.06.046_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/000456329803500106","article-title":"Screening for Down's syndrome: the effect of test date on the detection rate","volume":"35","author":"Dunstan","year":"1998","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.ajog.2016.06.046_bib8","first-page":"864","article-title":"Effect of study design on the association between nuchal translucency measurement and Down syndrome","volume":"94","author":"Mol","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.06.046_bib9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/pd.134","article-title":"What is the true fetal loss rate in pregnancies affected by trisomy 21 and how does this influence whether first trimester detection rates are superior to those in the second trimester?","volume":"21","author":"Spencer","year":"2001","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2016.06.046_bib10","first-page":"1066","article-title":"First-trimester sonographic screening for Down syndrome","volume":"102","author":"Malone","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2016.06.046_bib11","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/ajmg.a.32220","article-title":"The risk of fetal loss following a prenatal diagnosis of trisomy 13 or trisomy 18","volume":"146","author":"Morris","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajog.2016.06.046_bib12","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1093\/humrep\/dev192","article-title":"Only a minority of sex chromosome abnormalities are detected by a national prenatal screening program for Down syndrome","volume":"30","author":"Viuff","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2016.06.046_bib13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jc.2002-021491","article-title":"Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study","volume":"88","author":"Bojesen","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2016.06.046_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01213097","article-title":"Chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark","volume":"87","author":"Nielsen","year":"1991","journal-title":"Hum Genet"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293781630391X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293781630391X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:09:58Z","timestamp":1757588998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293781630391X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S000293781630391X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2016.06.046","relation":{},"ISSN":["0002-9378"],"issn-type":[{"type":"print","value":"0002-9378"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Where have all the trisomies gone?","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2016.06.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}