{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:28:26Z","timestamp":1776374906561,"version":"3.51.2"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.ajog.2016.08.018","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T05:33:02Z","timestamp":1471930382000},"page":"42.e1-42.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effect of letrozole on moderate and severe early-onset ovarian hyperstimulation syndrome in high-risk women:\u00a0a\u00a0prospective randomized trial"],"prefix":"10.1016","volume":"216","author":[{"given":"Qingyun","family":"Mai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canquan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2016.08.018_bib1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/humupd\/8.6.559","article-title":"Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review","volume":"8","author":"Delvigne","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2016.08.018_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0015-0282(16)55188-7","article-title":"Ovarian hyperstimulation syndrome in novel reproductive technologies: prevention and treatment","volume":"58","author":"Navot","year":"1992","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib3","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/oxfordjournals.humrep.a138598","article-title":"Early and late presentation of the ovarian hyperstimulation syndrome: two distinct entities with different risk factors","volume":"9","author":"Lyons","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2016.08.018_bib4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1477-7827-9-82","article-title":"Individualised controlled ovarian stimulation (iCOS): maximising success rates for assisted reproductive technology patients","volume":"9","author":"Bosch","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ajog.2016.08.018_bib5","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1210\/en.2002-220204","article-title":"Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade","volume":"143","author":"Gomez","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2016.08.018_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0140-6736(94)93001-5","article-title":"Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome","volume":"344","author":"McClure","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2016.08.018_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/humupd\/dmn008","article-title":"Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome","volume":"14","author":"Soares","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2016.08.018_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1472-6483(10)60212-X","article-title":"Luteal phase oestradiol suppression by letrozole: a pilot study in oocyte donors","volume":"17","author":"Fatemi","year":"2008","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ajog.2016.08.018_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.fertnstert.2008.04.042","article-title":"Letrozole administration during the luteal phase after ovarian stimulation impacts corpus luteum function: a randomized, placebo-controlled trial","volume":"92","author":"Garcia-Velasco","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fertnstert.2009.02.090","article-title":"Does coasting, a procedure to avoid ovarian hyperstimulation syndrome, affect assisted reproduction cycle outcome?","volume":"94","author":"Yilmaz","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/humupd\/8.3.291","article-title":"A\u00a0qualitative systematic review of coasting, a procedure to avoid ovarian hyperstimulation syndrome in IVF patients","volume":"8","author":"Delvigne","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2016.08.018_bib12","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.fertnstert.2009.01.085","article-title":"Low-dose aspirin therapy to prevent ovarian hyperstimulation syndrome","volume":"93","author":"Varnagy","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib13","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.fertnstert.2008.01.077","article-title":"Low-dose aspirin for prophylaxis of ovarian hyperstimulation syndrome","volume":"89","author":"Varnagy","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib14","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0015-0282(99)00090-4","article-title":"Prospective study of the clinical and laboratory parameters of patients in whom ovarian hyperstimulation syndrome developed during controlled ovarian hyperstimulation for in\u00a0vitro fertilization","volume":"71","author":"Enskog","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib15","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/humrep\/deg208","article-title":"Prediction of ovarian hyperstimulation syndrome (OHSS). Estradiol level has an important role in the prediction of OHSS","volume":"18","author":"Aboulghar","year":"2003","journal-title":"Hum Reproduction"},{"key":"10.1016\/j.ajog.2016.08.018_bib16","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0015-0282(00)00491-X","article-title":"The ovarian hyperstimulation syndrome","volume":"73","author":"Whelan","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1055\/s-0030-1265671","article-title":"Identification of the high-risk patient for ovarian hyperstimulation syndrome","volume":"28","author":"Papanikolaou","year":"2010","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.ajog.2016.08.018_bib18","first-page":"63","article-title":"Can steroidal ovarian suppression during the luteal phase after oocyte retrieval reduce the risk of severe OHSS?","volume":"8","author":"Wang","year":"2015","journal-title":"J\u00a0Ovar Res"},{"key":"10.1016\/j.ajog.2016.08.018_bib19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3109\/19396368.2014.957879","article-title":"Effects of different doses of letrozole on the incidence of early-onset ovarian hyperstimulation syndrome after oocyte retrieval","volume":"60","author":"He","year":"2014","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.ajog.2016.08.018_bib20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0015-0282(97)81908-5","article-title":"Vascular endothelial growth factor plasma levels correlate to the clinical picture in severe ovarian hyperstimulation syndrome","volume":"67","author":"Abramov","year":"1997","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0015-0282(98)00447-6","article-title":"Serum vascular endothelial growth factor concentrations in in\u00a0vitro fertilization cycles predict the risk of ovarian hyperstimulation syndrome","volume":"71","author":"Agrawal","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2016.08.018_bib22","first-page":"211","article-title":"Systematic review of data concerning etiopathology of ovarian hyperstimulation syndrome","volume":"47","author":"Delvigne","year":"2002","journal-title":"Int J Fertil Womens Med"},{"key":"10.1016\/j.ajog.2016.08.018_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/humupd\/3.3.255","article-title":"The role of vascular endothelial growth factor and interleukins in the pathogenesis of severe ovarian hyperstimulation syndrome","volume":"3","author":"Rizk","year":"1997","journal-title":"Hum Reprod Update"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293781630583X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293781630583X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:11:21Z","timestamp":1757589081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293781630583X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S000293781630583X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2016.08.018","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726669273.793535607","asserted-by":"object"}]},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of letrozole on moderate and severe early-onset ovarian hyperstimulation syndrome in high-risk women:\u00a0a\u00a0prospective randomized trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2016.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}