{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:56:47Z","timestamp":1789642607481,"version":"4.0.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.ajog.2017.10.005","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T03:02:42Z","timestamp":1507950162000},"page":"691.e1-691.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"title":["Positive predictive value estimates for cell-free noninvasive prenatal screening from data of a large referral genetic diagnostic laboratory"],"prefix":"10.1016","volume":"217","author":[{"given":"Andrea K.","family":"Petersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3813-5256","authenticated-orcid":false,"given":"Sau Wai","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Peacock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Braxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignatia B.","family":"Van Den Veyver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Breman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2017.10.005_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/uog.12513","article-title":"Non-invasive prenatal testing for aneuploidy: current status and future prospects","volume":"42","author":"Benn","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/AOG.0000000000000637","article-title":"Fetal sex chromosome testing by maternal plasma DNA sequencing: clinical laboratory experience and biology","volume":"125","author":"Bianchi","year":"2015","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib3","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/pd.4002","article-title":"Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors","volume":"32","author":"Dan","year":"2012","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2017.10.005_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/uog.14791","article-title":"Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis","volume":"45","author":"Gil","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib5","doi-asserted-by":"crossref","first-page":"e109173","DOI":"10.1371\/journal.pone.0109173","article-title":"Non-invasive prenatal chromosomal aneuploidy testing\u2014clinical experience: 100,000 clinical samples","volume":"9","author":"McCullough","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2017.10.005_bib6","doi-asserted-by":"crossref","first-page":"374.e1","DOI":"10.1016\/j.ajog.2012.08.033","article-title":"Noninvasive prenatal testing for fetal trisomies in a routinely screened first-trimester population","volume":"207","author":"Nicolaides","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/AOG.0000000000000363","article-title":"Single-nucleotide polymorphism-based noninvasive prenatal screening in a high-risk and low-risk cohort","volume":"124","author":"Pergament","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib8","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/uog.14792","article-title":"Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies","volume":"45","author":"Zhang","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/GIM.0b013e3182368a0e","article-title":"DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study","volume":"13","author":"Palomaki","year":"2011","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/uog.15754","article-title":"Clinical experience with single-nucleotide polymorphism-based non-invasive prenatal screening for 22q11.2 deletion syndrome","volume":"47","author":"Gross","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib11","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/pd.4640","article-title":"Clinical outcome of subchromosomal events detected by whole-genome noninvasive prenatal testing","volume":"35","author":"Helgeson","year":"2015","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2017.10.005_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/gim.2016.72","article-title":"Cell-free DNA testing of an extended range of chromosomal anomalies: clinical experience with 6,388 consecutive cases","volume":"19","author":"Pescia","year":"2017","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib13","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1056\/NEJMoa1203382","article-title":"Chromosomal microarray versus karyotyping for prenatal diagnosis","volume":"367","author":"Wapner","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib14","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/uog.12464","article-title":"Use of prenatal chromosomal microarray: prospective cohort study and systematic review and meta-analysis","volume":"41","author":"Hillman","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/gim.2015.196","article-title":"Expanding noninvasive prenatal testing to include microdeletions and segmental aneuploidy: cause for concern?","volume":"18","author":"Sahoo","year":"2016","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib16","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/gim.2014.197","article-title":"Maternal cell-free DNA-based screening for fetal microdeletion and the importance of careful diagnostic follow-up","volume":"17","author":"Yatsenko","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/aogs.13037","article-title":"Detection of fetal abnormalities by second-trimester ultrasound screening in a non-selected population","volume":"96","author":"Rydberg","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2017.10.005_bib18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/pd.4608","article-title":"Position statement from the Chromosome Abnormality Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis","volume":"35","author":"Benn","year":"2015","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2017.10.005_bib19","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/AOG.0000000000001439","article-title":"ACOG Practice Bulletin no. 163. Summary: screening for fetal aneuploidy","volume":"127","year":"2016","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib20","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/01.GIM.0000170992.63691.32","article-title":"Development and validation of a CGH microarray for clinical cytogenetic diagnosis","volume":"7","author":"Cheung","year":"2005","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib21","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1371\/journal.pone.0000327","article-title":"Clinical implementation of chromosomal microarray analysis: summary of 2513 postnatal cases","volume":"2","author":"Lu","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2017.10.005_bib22","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.clinbiochem.2015.02.011","article-title":"Cell-free DNA screening for fetal aneuploidy as a clinical service","volume":"48","author":"Cuckle","year":"2015","journal-title":"Clin Biochem"},{"key":"10.1016\/j.ajog.2017.10.005_bib23","doi-asserted-by":"crossref","first-page":"527.e1","DOI":"10.1016\/j.ajog.2014.08.006","article-title":"Clinical experience and follow-up with large scale single-nucleotide polymorphism-based noninvasive prenatal aneuploidy testing","volume":"211","author":"Dar","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib24","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1056\/NEJMoa1407349","article-title":"Cell-free DNA analysis for noninvasive examination of trisomy","volume":"372","author":"Norton","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib25","doi-asserted-by":"crossref","first-page":"214.e1","DOI":"10.1016\/j.ajog.2015.04.001","article-title":"Noninvasive prenatal screening for aneuploidy: positive predictive values based on cytogenetic findings","volume":"213","author":"Meck","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib26","doi-asserted-by":"crossref","first-page":"332.e1","DOI":"10.1016\/j.ajog.2014.11.041","article-title":"Expanding the scope of noninvasive prenatal testing: detection of fetal microdeletion syndromes","volume":"212","author":"Wapner","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/gim.2016.113","article-title":"Accuracy and clinical value of maternal incidental findings during noninvasive prenatal testing for fetal aneuploidies","volume":"19","author":"Brison","year":"2017","journal-title":"Genet Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1001\/jama.2015.7120","article-title":"Noninvasive prenatal testing and incidental detection of occult maternal malignancies","volume":"314","author":"Bianchi","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2017.10.005_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/pd.4100","article-title":"Discordant noninvasive prenatal testing results in a patient subsequently diagnosed with metastatic disease","volume":"33","author":"Osborne","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2017.10.005_bib30","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1016\/S2352-3026(14)00039-8","article-title":"Non-invasive detection of genomic imbalances in Hodgkin\/Reed-Sternberg cells in early and advanced stage Hodgkin's lymphoma by sequencing of circulating cell-free DNA: a technical proof-of-principle study","volume":"2","author":"Vandenberghe","year":"2015","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.ajog.2017.10.005_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1373\/clinchem.2013.215145","article-title":"Maternal mosaicism is a significant contributor to discordant sex chromosomal aneuploidies associated with noninvasive prenatal testing","volume":"60","author":"Wang","year":"2014","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2017.10.005_bib32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/pd.4076","article-title":"Secondary findings from non-invasive prenatal testing for common fetal aneuploidies by whole genome sequencing as a clinical service","volume":"33","author":"Lau","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2017.10.005_bib33","doi-asserted-by":"crossref","first-page":"79.e1","DOI":"10.1016\/j.ajog.2014.10.012","article-title":"Detection of triploid, molar, and vanishing twin\u00a0pregnancies by a single-nucleotide polymorphism-based noninvasive prenatal test","volume":"212","author":"Curnow","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib34","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMoa1408408","article-title":"Copy-number variation and false positive prenatal aneuploidy screening results","volume":"372","author":"Snyder","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2017.10.005_bib35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ajog.2016.04.029","article-title":"Noninvasive prenatal screening or advanced diagnostic testing: caveat emptor","volume":"215","author":"Evans","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.10.005_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/pd.4710","article-title":"Current controversies in prenatal diagnosis 1: should NIPT routinely include microdeletions\/microduplications?","volume":"36","author":"Rose","year":"2016","journal-title":"Prenat Diagn"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937817311870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937817311870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:15:58Z","timestamp":1757589358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937817311870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0002937817311870"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2017.10.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.731997757.793559896","asserted-by":"object"}]},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positive predictive value estimates for cell-free noninvasive prenatal screening from data of a large referral genetic diagnostic laboratory","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2017.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}