{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:27:05Z","timestamp":1793604425356,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1-RR-024131"],"award-info":[{"award-number":["UL1-RR-024131"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1-RR-024134"],"award-info":[{"award-number":["UL1-RR-024134"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1-RR-024975"],"award-info":[{"award-number":["UL1-RR-024975"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U01 HD041665"],"award-info":[{"award-number":["U01 HD041665"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U10 HD041666"],"award-info":[{"award-number":["U10 HD041666"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U10 HD041667"],"award-info":[{"award-number":["U10 HD041667"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U10 HD041669"],"award-info":[{"award-number":["U10 HD041669"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","ajog.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.ajog.2017.12.001","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T23:29:42Z","timestamp":1513121382000},"page":"256.e1-256.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":231,"title":["The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes"],"prefix":"10.1016","volume":"218","author":[{"given":"Diana L.","family":"Farmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Thom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John W.","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela K.","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori J.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody A.","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalin","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Scott","family":"Adzick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2017.12.001_bib1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/bdra.20360","article-title":"Health care expenditures of children and adults with spina bifida in a privately insured US population","volume":"79","author":"Ouyang","year":"2007","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ajog.2017.12.001_bib2","first-page":"264","article-title":"Economic burden of spina bifida\u2013United States, 1980-1990","volume":"38","author":"Centers for Disease Control","year":"1989","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.ajog.2017.12.001_bib3","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1001\/archsurg.138.8.872","article-title":"In-utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomes","volume":"138","author":"Farmer","year":"2003","journal-title":"Arch Surg"},{"key":"10.1016\/j.ajog.2017.12.001_bib4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1067\/S0002-9378(03)00295-3","article-title":"Fetal myelomeningocele repair: short-term clinical outcomes","volume":"189","author":"Johnson","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.12.001_bib5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.ajog.2006.01.072","article-title":"Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of age","volume":"194","author":"Johnson","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.12.001_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000197359","article-title":"Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery","volume":"25","author":"Danzer","year":"2009","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ajog.2017.12.001_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1055\/s-0029-1202835","article-title":"Reversal of hindbrain herniation after maternal-fetal surgery for myelomeningocele subsequently impacts on brain stem function","volume":"39","author":"Danzer","year":"2008","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ajog.2017.12.001_bib8","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1014379","article-title":"A\u00a0randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"Adzick","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2017.12.001_bib9","doi-asserted-by":"crossref","first-page":"778.e1","DOI":"10.1016\/j.ajog.2016.07.052","article-title":"The Management of Myelomeningocele Study: obstetrical outcomes and risk factors for obstetrical complications following prenatal surgery","volume":"215","author":"Johnson","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2017.12.001_bib10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3171\/2015.7.PEDS15336","article-title":"Prenatal surgery for myelomeningocele and the need for cerebrospinal fluid shunt placement","volume":"16","author":"Tulipan","year":"2015","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.ajog.2017.12.001_bib11","doi-asserted-by":"crossref","first-page":"e906","DOI":"10.1542\/peds.2015-2114","article-title":"Bladder function after fetal surgery for myelomeningocele","volume":"136","author":"Brock","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2017.12.001_bib12","article-title":"Fetal surgery for myelomeningocele: a systematic review and meta-analysis of outcomes in fetoscopic vs open repair","author":"Kabagambe","year":"2017","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ajog.2017.12.001_bib13","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5966\/sctm.2014-0296","article-title":"Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele","volume":"4","author":"Wang","year":"2015","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.ajog.2017.12.001_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000433427","article-title":"Age does matter: a pilot comparison of placenta-derived stromal cells for in utero repair of myelomeningocele using a lamb model","volume":"39","author":"Brown","year":"2016","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ajog.2017.12.001_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biomaterials.2015.10.051","article-title":"Complete tissue coverage achieved by scaffold-based tissue engineering in the fetal sheep model of myelomeningocele","volume":"76","author":"Watanabe","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ajog.2017.12.001_bib16","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1089\/ten.tea.2010.0390","article-title":"A\u00a0tissue engineering approach for prenatal closure of myelomeningocele: comparison of gelatin sponge and microsphere scaffolds and bioactive protein coatings","volume":"17","author":"Watanabe","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.ajog.2017.12.001_bib17","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jpedsurg.2015.03.034","article-title":"Trans-amniotic stem cell therapy (TRASCET) minimizes Chiari-II malformation in experimental spina bifida","volume":"50","author":"Dionigi","year":"2015","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.ajog.2017.12.001_bib18","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jpedsurg.2016.02.071","article-title":"A\u00a0comparison between placental and amniotic mesenchymal stem cells for transamniotic stem cell therapy (TRASCET) in experimental spina bifida","volume":"51","author":"Feng","year":"2016","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.ajog.2017.12.001_bib19","doi-asserted-by":"crossref","first-page":"587.e1","DOI":"10.1016\/j.ajog.2017.07.022","article-title":"Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele","volume":"217","author":"Tarui","year":"2017","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937817324754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937817324754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T08:14:45Z","timestamp":1742717685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937817324754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0002937817324754"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2017.12.001","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2017.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}