{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:59:51Z","timestamp":1793177991990,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Sanquin Blood Supply","award":["Product and Process Development 14\u201315"],"award-info":[{"award-number":["Product and Process Development 14\u201315"]}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ajog.2018.07.020","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T02:11:36Z","timestamp":1532830296000},"page":"393.e1-393.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Predicting anti-Kell-mediated hemolytic disease of\u00a0the\u00a0fetus and newborn: diagnostic accuracy of laboratory management"],"prefix":"10.1016","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8209-7237","authenticated-orcid":false,"given":"Yolentha M.","family":"Slootweg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene T.","family":"Lindenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke M.","family":"Koelewijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge L.","family":"Van Kamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masja","family":"De Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2018.07.020_bib1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1537-2995.2007.01625.x","article-title":"Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in The Netherlands","volume":"48","author":"Koelewijn","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.ajog.2018.07.020_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/vox.12265","article-title":"Hemolytic disease of the fetus and newborn","volume":"109","author":"de Haas","year":"2015","journal-title":"Vox Sang"},{"key":"10.1016\/j.ajog.2018.07.020_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0002-9378(94)90477-4","article-title":"Erythropoietic suppression in fetal anemia because of Kell alloimmunization","volume":"171","author":"Vaughan","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.07.020_bib4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0002-9378(96)70425-8","article-title":"Decreased fetal erythropoiesis and hemolysis in Kell hemolytic anemia","volume":"174","author":"Weiner","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.07.020_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1537-2995.2003.00327.x","article-title":"Causes of fetal anemia in hemolytic disease due to anti-K","volume":"43","author":"Daniels","year":"2003","journal-title":"Transfusion"},{"key":"10.1016\/j.ajog.2018.07.020_bib6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1537-2995.2007.01626.x","article-title":"Implementation of routine screening for Kell antibodies: does it improve perinatal survival?","volume":"48","author":"Kamphuis","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.ajog.2018.07.020_bib7","series-title":"Alloimmune disorders of pregnancy. Anemia, thrombocytopenia and neutropenia in the fetus and newborn","article-title":"Blood group antibodies in hemolytic disease of the fetus and newborn","author":"Daniels","year":"2002"},{"key":"10.1016\/j.ajog.2018.07.020_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.siny.2008.02.007","article-title":"Fetal anemia due to non-Rhesus-D red-cell alloimmunization","volume":"13","author":"Moise","year":"2008","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2018.07.020_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/AOG.0b013e31817d453c","article-title":"Management of rhesus alloimmunization in pregnancy","volume":"112","author":"Moise","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.07.020_bib10","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0140-6736(09)60651-6","article-title":"Prevention of rhesus hemolytic disease of the fetus and newborn","volume":"373","author":"Franklin","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2018.07.020_bib11","series-title":"Mollison's blood transfusion in clinical medicine","first-page":"499","article-title":"Hemolytic disease of the fetus and the newborn","author":"Klein","year":"2012"},{"key":"10.1016\/j.ajog.2018.07.020_bib12","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMra1308124","article-title":"Bilirubin-induced neurologic damage\u2013mechanisms and management approaches","volume":"369","author":"Watchko","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl","key":"10.1016\/j.ajog.2018.07.020_bib13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/pr.2013.208","article-title":"Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels","volume":"74","author":"Bhutani","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajog.2018.07.020_bib14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.0001-6349.2004.00394.x","article-title":"Treatment of fetal anemia due to red-cell alloimmunization with intrauterine transfusions in The Netherlands, 1988-1999","volume":"83","author":"Van Kamp","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2018.07.020_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ajog.2011.09.024","article-title":"Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus\/newborn: the LOTUS study","volume":"206","author":"Lindenburg","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.07.020_bib16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1423-0410.2010.01408.x","article-title":"Exchange transfusions and top-up transfusions in neonates with Kell hemolytic disease compared to Rh D hemolytic disease","volume":"100","author":"Rath","year":"2011","journal-title":"Vox Sang"},{"key":"10.1016\/j.ajog.2018.07.020_bib17","unstructured":"NVOG Dutch Association Obstetrics and Gynecology. Red blood cell immunization and pregnancy. Version 2.1. 2009. Available at: https:\/\/www.nvog.nl\/wp-content\/uploads\/2018\/03\/Erytrocytenimmunisatie-en-zwangerschap_.pdf. Accessed August 31, 2018."},{"key":"10.1016\/j.ajog.2018.07.020_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00006250-200608000-00044","article-title":"Management of alloimmunization during pregnancy. Practice bulletin no. 75","volume":"108","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.07.020_bib19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1056\/NEJMoa052855","article-title":"Doppler ultrasonography versus amniocentesis to predict fetal anemia","volume":"355","author":"Oepkes","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2018.07.020_bib20","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/pd.2551","article-title":"Management of red cell alloimmunization in pregnancy: the non-invasive monitoring of the disease","volume":"30","author":"Illanes","year":"2010","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2018.07.020_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJM200001063420102","article-title":"Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in\u00a0Anemic Fetuses","volume":"342","author":"Mari","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2018.07.020_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.siny.2008.02.005","article-title":"Rhesus hemolytic disease of the newborn: postnatal management, associated morbidity and long-term outcome","volume":"13","author":"Smits-Wintjens","year":"2008","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2018.07.020_bib23","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1471-0528.2011.03028.x","article-title":"Noninvasive fetal blood group genotyping of rhesus D, c, E and of K in alloimmunized pregnant women: evaluation of a 7-year clinical experience","volume":"118","author":"Scheffer","year":"2011","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2018.07.020_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0950-3536(05)80053-8","article-title":"ADCC and other cellular bioassays for predicting the clinical significance of red cell alloantibodies","volume":"3","author":"Engelfriet","year":"1990","journal-title":"Baillieres Clin Haematol"},{"key":"10.1016\/j.ajog.2018.07.020_bib25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2141.1980.tb05992.x","article-title":"ADCC (K-cell) lysis of human erythrocytes sensitized with rhesus alloantibodies. III. Comparison of IgG anti-D agglutinating and lytic (ADCC) activity and the role of IgG subclasses","volume":"46","author":"Urbaniak","year":"1980","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ajog.2018.07.020_bib26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0966-3274(02)00065-5","article-title":"Laboratory assays for predicting the severity of hemolytic disease of the fetus and newborn","volume":"10","author":"Hadley","year":"2002","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.ajog.2018.07.020_bib27","first-page":"667","article-title":"Management of pregnancies complicated by anti-Kell isoimmunization","volume":"93","author":"McKenna","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.07.020_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1471-0528.1991.tb13362.x","article-title":"Anti-Kell in pregnancy","volume":"98","author":"Leggat","year":"1991","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2018.07.020_bib29","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/01.AOG.0000260957.77090.4e","article-title":"Obstetric history and antibody titer in estimating severity of Kell alloimmunization in pregnancy","volume":"109","author":"van Wamelen","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.07.020_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0301-2115(00)00428-0","article-title":"Non-anti-D antibodies in red-cell alloimmunization","volume":"92","author":"Moise","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2018.07.020_bib31","unstructured":"de Haas M, Koelewijn JM, Bilgin K, Vrijkotte TGM, van der Schoot CE, Bonsel GJ. Diagnostic performance of laboratory monitoring to predict severe hemolytic disease of the fetus and newborn in non-RhD-alloimmunized pregnancies. Detection and prevention of pregnancy immunization, the OPZI-study, Academic Thesis 2009;4:73-85."},{"key":"10.1016\/j.ajog.2018.07.020_bib32","first-page":"539","article-title":"Intrauterine transfusion","volume":"92","author":"Liley","year":"1971","journal-title":"Ann Obstet Ginecol Med Perinat"},{"key":"10.1016\/j.ajog.2018.07.020_bib33","unstructured":"Downes KAS, IA. Pretransfusion testing. In: Fung MG, BJ, Hillyer CD, Westhoff CM, eds. Technical manual, 18th ed. Bethesda (MD): AABB."},{"key":"10.1016\/j.ajog.2018.07.020_bib34","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/bjh.14438","article-title":"Antigen specificity determines anti-red blood cell IgG-Fc alloantibody glycosylation and thereby severity of hemolytic disease of the fetus and newborn","volume":"176","author":"Sonneveld","year":"2017","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ajog.2018.07.020_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2141.1991.tb07981.x","article-title":"Correlation of serological, quantitative and cell-mediated functional assays of maternal alloantibodies with the severity of hemolytic disease of the newborn","volume":"77","author":"Hadley","year":"1991","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ajog.2018.07.020_bib36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/ajcp\/92.1.89","article-title":"Monocyte monolayer assay: an efficient noninvasive technique for predicting the severity of hemolytic disease of the newborn","volume":"92","author":"Nance","year":"1989","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ajog.2018.07.020_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1053\/tmrv.2003.50001","article-title":"Prenatal typing of Rh and Kell blood group system antigens: the edge of a watershed","volume":"17","author":"Ellen van der Schoot","year":"2003","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.ajog.2018.07.020_bib38","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1111\/j.1537-2995.2007.01437.x","article-title":"Fetal genotyping for the K (Kell) and Rh C, c, and E blood groups on cell-free fetal DNA in maternal plasma","volume":"47","author":"Finning","year":"2007","journal-title":"Transfusion"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937818306070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937818306070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:33:54Z","timestamp":1762079634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937818306070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0002937818306070"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2018.07.020","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting anti-Kell-mediated hemolytic disease of\u00a0the\u00a0fetus and newborn: diagnostic accuracy of laboratory management","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2018.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}