{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:48:16Z","timestamp":1790077696285,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ajog.2018.08.001","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T23:14:58Z","timestamp":1538090098000},"page":"315-319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Systematic screening and treatment of toxoplasmosis during pregnancy: is the glass\u00a0half full or half empty?"],"prefix":"10.1016","volume":"219","author":[{"given":"Jose G.","family":"Montoya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2018.08.001_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ajog.2018.05.031","article-title":"Prenatal therapy with pyrimethamine\u00a0+ sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial","volume":"219","author":"Mandelbrot","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ajog.2018.08.001_bib2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-3860","article-title":"Diagnosis, treatment, and prevention of congenital toxoplasmosis in the United States","volume":"139","author":"Maldonado","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2018.08.001_bib3","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1056\/NEJM197405162902003","article-title":"Congenital toxoplasmosis: a prospective study of 378 pregnancies","volume":"290","author":"Desmonts","year":"1974","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2018.08.001_bib4","series-title":"Pathophysiology of congenital disease. Perinatal Medicine, 6th European Congress","first-page":"51","article-title":"Congenital toxoplasmosis: a prospective study of the offspring of 542 women who acquired toxoplasmosis during pregnancy","author":"Desmonts","year":"1979"},{"issue":"supplB","key":"10.1016\/j.ajog.2018.08.001_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/jac\/22.Supplement_B.193","article-title":"Prophylaxis of congenital toxoplasmosis: effects of spiramycin on placental infection","volume":"22","author":"Couvreur","year":"1988","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.ajog.2018.08.001_bib6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJM198802043180502","article-title":"Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis","volume":"318","author":"Daffos","year":"1988","journal-title":"N\u00a0Engl J\u00a0Med"},{"key":"10.1016\/j.ajog.2018.08.001_bib7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0022-3476(89)80660-2","article-title":"Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment","volume":"115","author":"Hohlfeld","year":"1989","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ajog.2018.08.001_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/INF.0b013e318134286d","article-title":"Risk factors for retinochoroiditis during the first 2 years of life in infants with treated congenital toxoplasmosis","volume":"27","author":"Kieffer","year":"2008","journal-title":"Pediatric Infect Dis J"},{"key":"10.1016\/j.ajog.2018.08.001_bib9","doi-asserted-by":"crossref","first-page":"e1000351","DOI":"10.1371\/journal.pmed.1000351","article-title":"Prenatal treatment for serious neurological sequelae of congenital toxoplasmosis: an observational prospective cohort study","volume":"7","author":"Cortina-Borja","year":"2010","journal-title":"PLoS Med"},{"key":"10.1016\/j.ajog.2018.08.001_bib10","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/cid\/cis234","article-title":"Efficacy of rapid treatment initiation following primary toxoplasma gondii infection during pregnancy","volume":"54","author":"Hotop","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2018.08.001_bib11","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/cid\/cit032","article-title":"Congenital toxoplasma infection: monthly prenatal screening decreases transmission rate and improves clinical outcome at age 3 years","volume":"56","author":"Wallon","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2018.08.001_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2334-14-33","article-title":"Congenital toxoplasmosis and prenatal care state programs","volume":"14","author":"Avelino","year":"2014","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ajog.2018.08.001_bib13","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1093\/cid\/ciu724","article-title":"The Austrian Toxoplasmosis Register, 1992-2008","volume":"60","author":"Prusa","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2018.08.001_bib14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0002-9378(99)70224-3","article-title":"Treatment of toxoplasmosis during pregnancy: a multicenter study of impact on fetal transmission and children\u2019s sequelae at age 1 year","volume":"180","author":"Foulon","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.08.001_bib15","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/ije\/30.6.1303","article-title":"Effect of prenatal treatment on mother to child transmission of Toxoplasma gondii: retrospective cohort study of 554 mother-child pairs in Lyon, France","volume":"30","author":"Gilbert","year":"2001","journal-title":"Int J\u00a0Epidemiol"},{"key":"10.1016\/j.ajog.2018.08.001_bib16","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/ije\/30.6.1309","article-title":"Effect of prenatal treatment on the risk of intracranial and ocular lesions in children with congenital toxoplasmosis","volume":"30","author":"Gras","year":"2001","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ajog.2018.08.001_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1471-0528.2003.02325.x","article-title":"European Multicentre Study on Congenital Toxoplasmosis. Effect of timing and type of treatment on the risk of mother to child transmission of Toxoplasma gondii","volume":"110","author":"Gilbert","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2018.08.001_bib18","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/j.1651-2227.2005.tb01844.x","article-title":"Association between prenatal treatment and clinical manifestations of congenital toxoplasmosis in infancy: a cohort study in 13 European centres","volume":"94","author":"Gras","year":"2005","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.ajog.2018.08.001_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0140-6736(07)60072-5","article-title":"Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients\u2019 data","volume":"369","author":"Thiebaut","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2018.08.001_bib20","first-page":"903","article-title":"[Comparative effect of various synthetic agents and various antibiotics, including spiramycin, on Toxoplasma]","volume":"47","author":"Bogacz","year":"1954","journal-title":"Bull Soc Pathol Exot Filiales"},{"key":"10.1016\/j.ajog.2018.08.001_bib21","first-page":"2266","article-title":"[Bases theoriques de la prevention par la spiramycine de la toxoplasmose congenitale chez la femme enceinte] <Original> Theoretical bases of the prevention by spiramycin of congenital toxoplasmosis in pregnant women","volume":"76","author":"Garin","year":"1968","journal-title":"Presse Med"},{"key":"10.1016\/j.ajog.2018.08.001_bib22","first-page":"539","article-title":"[Suivi therapeutique foetomaternel de la spiramycine en cours de grossesse.]","volume":"44","author":"Forestier","year":"1987","journal-title":"Arch Fr Pediatr"},{"key":"10.1016\/j.ajog.2018.08.001_bib23","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1128\/JCM.00487-16","article-title":"Laboratory diagnosis of congenital toxoplasmosis","volume":"54","author":"Pomares","year":"2016","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.ajog.2018.08.001_bib24","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(98)08220-8","article-title":"Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling","volume":"353","author":"Dunn","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2018.08.001_bib25","first-page":"104","article-title":"Long-term ocular outcome in congenital toxoplasmosis: a prospective cohort of treated children","volume":"64","author":"Faucher","year":"2012","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.ajog.2018.08.001_bib26","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1086\/590149","article-title":"Management of Toxoplasma gondii infection during pregnancy","volume":"47","author":"Montoya","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2018.08.001_bib27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/INF.0b013e31820bb5f3","article-title":"Long-term impact of treated congenital toxoplasmosis on quality of life and visual performance","volume":"30","author":"Peyron","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ajog.2018.08.001_bib28","series-title":"Infectious diseases of the fetus and newborn infant","first-page":"949","article-title":"Toxoplasmosis","author":"Peyron","year":"2015"},{"key":"10.1016\/j.ajog.2018.08.001_bib29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/bmj.321.7254.142","article-title":"Sources of toxoplasma infection in pregnant women: European multicentre case-control study","volume":"321","author":"Cook","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2018.08.001_bib30","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ajog.2004.07.031","article-title":"Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: implications for prenatal management and screening","volume":"192","author":"Boyer","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.08.001_bib31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2471\/BLT.12.111732","article-title":"The global burden of congenital toxoplasmosis: a systematic review","volume":"91","author":"Torgerson","year":"2013","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.ajog.2018.08.001_bib32","doi-asserted-by":"crossref","first-page":"e0005222","DOI":"10.1371\/journal.pntd.0005222","article-title":"Congenital toxoplasmosis in France and the United States: one parasite, two diverging approaches","volume":"11","author":"Peyron","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ajog.2018.08.001_bib33","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1097\/01.AOG.0000466430.19823.53","article-title":"Practice Bulletin no. 151: Cytomegalovirus, parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy","volume":"125","year":"2015","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2018.08.001_bib34","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1097\/INF.0b013e3182343096","article-title":"Severe\u00a0congenital toxoplasmosis in the United States: clinical and serologic findings in untreated infants","volume":"30","author":"Olariu","year":"2011","journal-title":"Pediatric Infect Dis J"},{"key":"10.1016\/j.ajog.2018.08.001_bib35","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4269\/ajtmh.17-0677","article-title":"Toxoplasma gondii Infection in the United States, 2011-2014","volume":"98","author":"Jones","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ajog.2018.08.001_bib36","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pt.2011.09.005","article-title":"The placenta: a main role in congenital toxoplasmosis?","volume":"27","author":"Robert-Gangneux","year":"2011","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.ajog.2018.08.001_bib37","doi-asserted-by":"crossref","first-page":"a010090","DOI":"10.1101\/cshperspect.a010090","article-title":"Concepts and mechanisms: crossing host barriers","volume":"3","author":"Doran","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.ajog.2018.08.001_bib38","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mib.2011.11.006","article-title":"Pathogens and the placental fortress","volume":"15","author":"Robbins","year":"2012","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.ajog.2018.08.001_bib39","doi-asserted-by":"crossref","first-page":"e1333","DOI":"10.1371\/journal.pntd.0001333","article-title":"Maternal serologic screening to prevent congenital toxoplasmosis: a decision-analytic economic model","volume":"5","author":"Stillwaggon","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ajog.2018.08.001_bib40","doi-asserted-by":"crossref","first-page":"e0005670","DOI":"10.1371\/journal.pntd.0005670","article-title":"Point-of-care testing for Toxoplasma gondii IgG\/IgM using Toxoplasma ICT IgG-IgM test with sera from the United States and implications for developing countries","volume":"11","author":"Begeman","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ajog.2018.08.001_bib41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.diagmicrobio.2016.09.001","article-title":"Validation of IgG, IgM multiplex plasmonic gold platform in French clinical cohorts for the serodiagnosis and follow-up of Toxoplasma gondii infection","volume":"87","author":"Pomares","year":"2017","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937818306537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937818306537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:18:54Z","timestamp":1757589534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937818306537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0002937818306537"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2018.08.001","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic screening and treatment of toxoplasmosis during pregnancy: is the glass\u00a0half full or half empty?","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2018.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2018.05.031","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}