{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:25:25Z","timestamp":1792578325474,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HD 036455"],"award-info":[{"award-number":["R01 HD 036455"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HD007440"],"award-info":[{"award-number":["HD007440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ajog.2019.01.002","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T17:18:45Z","timestamp":1546967925000},"page":"95-108.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Two-dose versus single-dose methotrexate for treatment of ectopic pregnancy: a meta-analysis"],"prefix":"10.1016","volume":"221","author":[{"given":"Snigdha","family":"Alur-Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura G.","family":"Cooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneeta","family":"Senapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary D.","family":"Sammel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt T.","family":"Barnhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2019.01.002_bib1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/GRF.0b013e3182516d7b","article-title":"Ectopic pregnancy: History, incidence, epidemiology, and risk factors","volume":"55","author":"Marion","year":"2012","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib2","first-page":"CD00324","article-title":"Interventions for tubal ectopic pregnancy","author":"Hajenius","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajog.2019.01.002_bib3","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1097\/AOG.0000000000002560","article-title":"ACOG practice bulletin no. 193: tubal ectopic pregnancy","volume":"131","year":"2018","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1056\/NEJMcp0810384","article-title":"Clinical practice. Ectopic pregnancy","volume":"361","author":"Barnhart","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2019.01.002_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1517\/14656566.2.3.409","article-title":"The pharmacology of methotrexate","volume":"2","author":"Barnhart","year":"2001","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.ajog.2019.01.002_bib6","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0140-6736(97)05487-1","article-title":"Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy","volume":"350","author":"Hajenius","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2019.01.002_bib7","first-page":"67","article-title":"Ectopic pregnancy; risk factors and comparison of intervention success rates in tubal ectopic pregnancy","volume":"38","author":"Kazandi","year":"2011","journal-title":"Clin Exp Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib8","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3109\/00016340903188912","article-title":"Success and spontaneous pregnancy rates following systemic methotrexate versus laparoscopic surgery for tubal pregnancies: a randomized trial","volume":"88","author":"Krag Moeller","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2019.01.002_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/humupd\/dmn012","article-title":"Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis","volume":"14","author":"Mol","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2019.01.002_bib10","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1056\/NEJM199912233412604","article-title":"Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies","volume":"341","author":"Lipscomb","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2019.01.002_bib11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.fertnstert.2006.06.054","article-title":"Use of \"2-dose\" regimen of methotrexate to treat ectopic pregnancy","volume":"87","author":"Barnhart","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.01.002_bib12","first-page":"778","article-title":"The medical management of ectopic pregnancy: a meta-analysis comparing \"single dose\" and \"multidose\" regimens","volume":"101","author":"Barnhart","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3109\/00016349.2010.486825","article-title":"Comparison of single and multiple dose methotrexate therapy for unruptured tubal ectopic pregnancy: a prospective randomized study","volume":"89","author":"Guvendag Guven","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2019.01.002_bib14","doi-asserted-by":"crossref","first-page":"e20147","DOI":"10.5812\/ircmj.20147","article-title":"Comparison of two different protocols of methotrexate therapy in medical management of ectopic pregnancy","volume":"17","author":"Saadati","year":"2015","journal-title":"Iranian Red Crescent Med J"},{"key":"10.1016\/j.ajog.2019.01.002_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijgo.2011.08.009","article-title":"Comparison of double- and single-dose methotrexate protocols for treatment of ectopic pregnancy","volume":"116","author":"Hamed","year":"2012","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajog.2019.01.002_bib16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/01443615.2011.560301","article-title":"Comparison of single-dose and two-dose methotrexate protocols for the treatment of unruptured ectopic\u00a0pregnancy","volume":"31","author":"Gungorduk","year":"2011","journal-title":"J\u00a0Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib17","first-page":"189","article-title":"Fertility outcome after treatment of unruptured ectopic pregnancy with two different methotrexate protocols","volume":"6","author":"Tabatabaii Bafghi","year":"2012","journal-title":"Int J Fertil Steril"},{"key":"10.1016\/j.ajog.2019.01.002_bib18","first-page":"749","article-title":"Efficacy and side effects of methotrexate in the treatment of ectopic pregnancy","volume":"38","author":"Chen","year":"2003","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.ajog.2019.01.002_bib19","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.ajog.2004.12.061","article-title":"Comparison of multidose and single-dose methotrexate protocols for the treatment of ectopic pregnancy","volume":"192","author":"Lipscomb","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5468\/ogs.2017.60.1.79","article-title":"Pretreatment serum human chorionic gonadotropin cutoff value for medical treatment success with single-dose and multi-dose regimen of methotrexate in tubal ectopic pregnancy","volume":"60","author":"Kim","year":"2017","journal-title":"Obstet Gynecol Science"},{"key":"10.1016\/j.ajog.2019.01.002_bib21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ajog.2016.06.040","article-title":"Medical management of ectopic pregnancy with single-dose and 2-dose methotrexate protocols: human chorionic gonadotropin trends and patient outcomes","volume":"215","author":"Mergenthal","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.rbmo.2017.01.004","article-title":"Multiple-dose and double-dose versus single-dose administration of methotrexate for the treatment of ectopic pregnancy: a systematic review and meta-analysis","volume":"34","author":"Yang","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ajog.2019.01.002_bib23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ijgo.12473","article-title":"Systematic review and meta-analysis of single-dose and non-single-dose methotrexate protocols in the treatment of ectopic pregnancy","volume":"141","author":"Yuk","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajog.2019.01.002_bib24","first-page":"92","article-title":"Three different regimens of methotrexate for the treatment of ectopic pregnancy","author":"Cardamakis","year":"1997","journal-title":"XV FIGO World Congress of Obstetrics & Gynecology"},{"key":"10.1016\/j.ajog.2019.01.002_bib25","unstructured":"Shahrzad M. Comparison of single and multiple-dose methotrexate therapy for ectopic pregnancy: a clinical trial. Clinicaltrials.gov. Study ID: NCT01662167. Available at: https:\/\/clinicaltrials.gov\/show\/nct01662167. Accessed July 16, 2018."},{"key":"10.1016\/j.ajog.2019.01.002_bib26","first-page":"64S","article-title":"Methotrexate for ectopic pregnancy: a randomized \u201csingle dose\u201d compared with \u201cmultidose\u201d trial","volume":"105","author":"Klauser","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1034\/j.1600-0412.2001.080008744.x","article-title":"Clinical and pregnancy outcome following ectopic pregnancy; a prospective study comparing expectancy, surgery and systemic methotrexate treatment","volume":"80","author":"Olofsson","year":"2001","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2019.01.002_bib28","first-page":"74","article-title":"Comparison of single and two dose of methotrexate in treatment of ectopic pregnancy","volume":"10","author":"Golmohammadlou","year":"2012","journal-title":"Iran J Reprod Med"},{"key":"10.1016\/j.ajog.2019.01.002_bib29","first-page":"1054","article-title":"Comparison of single-dose and multiple-dose systemic methotrexate regimen for ectopic pregnancy","volume":"32","author":"Fakheri","year":"2014","journal-title":"J\u00a0Isfahan Med Sch"},{"key":"10.1016\/j.ajog.2019.01.002_bib30","first-page":"586","article-title":"Comparision of single and multidose of methotrexate in medical treatment of ectopic pregnancy","volume":"24","author":"Zargar","year":"2008","journal-title":"Pakistan J Med Sci"},{"key":"10.1016\/j.ajog.2019.01.002_bib31","first-page":"564","article-title":"Comparison of single and multiple-dose methotrexate therapy for ectopic pregnancy: a clinical trial","volume":"10","author":"Amirian","year":"2013","journal-title":"Life Sci J"},{"key":"10.1016\/j.ajog.2019.01.002_bib32","first-page":"6","article-title":"Double versus single dose methotrexate regimens in management of undisturbed ectopic pregnancy","volume":"2","author":"Saleh","year":"2016","journal-title":"Crit Care Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib33","first-page":"332","article-title":"Single-dose versus two-dose administration of methotrexate for the treatment of ectopic pregnancy: a randomized controlled trial","volume":"31","author":"Song","year":"2016","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2019.01.002_bib34","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.fertnstert.2005.11.055","article-title":"Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial","volume":"85","author":"Alleyassin","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.01.002_bib35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/1471-0528.14752","article-title":"Comparison of management regimens following ultrasound diagnosis of nontubal ectopic pregnancies: a retrospective cohort study","volume":"125","author":"Ramkrishna","year":"2018","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.01.002_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.rbmo.2016.03.011","article-title":"Management of non-tubal ectopic pregnancies at a large tertiary hospital","volume":"33","author":"Hunt","year":"2016","journal-title":"Reprod Biomed Online"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937819300043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937819300043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:26:06Z","timestamp":1757589966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937819300043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0002937819300043"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2019.01.002","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two-dose versus single-dose methotrexate for treatment of ectopic pregnancy: a meta-analysis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2019.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}