{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:19:02Z","timestamp":1780730342619,"version":"3.54.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ajog.2019.09.047","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T01:45:50Z","timestamp":1570153550000},"page":"360.e1-360.e16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Placental pathology in live births conceived with in\u00a0vitro fertilization after fresh and frozen embryo transfer"],"prefix":"10.1016","volume":"222","author":[{"given":"Caitlin R.","family":"Sacha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Basnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor S.","family":"Freret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Kaimal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Souter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drucilla J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2019.09.047_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10815-010-9387-6","article-title":"Ovarian hyperstimulation syndrome: pathophysiology and prevention","volume":"27","author":"Nastri","year":"2010","journal-title":"J\u00a0Assist Reprod Genet"},{"key":"10.1016\/j.ajog.2019.09.047_bib2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.fertnstert.2012.08.060","article-title":"Elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes: a preliminary study","volume":"99","author":"Imudia","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib3","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.fertnstert.2012.03.028","article-title":"Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in\u00a0vitro fertilization","volume":"97","author":"Imudia","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.fertnstert.2012.05.019","article-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in\u00a0vitro fertilization treatment: a systematic review and meta-analysis","volume":"98","author":"Maheshwari","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.fertnstert.2017.10.019","article-title":"Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in\u00a0vitro fertilization: a meta-analysis","volume":"109","author":"Sha","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.fertnstert.2018.11.043","article-title":"Risk of ischemic placental disease in fresh and frozen embryo transfer cycles","volume":"111","author":"Johnson","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.fertnstert.2011.02.059","article-title":"Evidence of impaired endometrial receptivity after ovarian stimulation for in\u00a0vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders","volume":"96","author":"Shapiro","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.fertnstert.2010.05.049","article-title":"Perinatal morbidity after in\u00a0vitro fertilization is lower with frozen embryo transfer","volume":"95","author":"Kansal Kalra","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib9","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.fertnstert.2015.01.021","article-title":"Cryopreserved embryo transfer is an independent risk factor for placenta accreta","volume":"103","author":"Kaser","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib10","first-page":"253","article-title":"Obstetric outcomes after fresh versus frozen-thawed embryo transfers: a systematic review and meta-analysis","volume":"22","author":"Roque","year":"2018","journal-title":"JBRA Assist Reprod"},{"key":"10.1016\/j.ajog.2019.09.047_bib11","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.fertnstert.2017.08.035","article-title":"Embryo cryopreservation and preeclampsia risk","volume":"108","author":"Sites","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh versus frozen embryos for infertility in the polycystic ovary syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2019.09.047_bib13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.fertnstert.2017.10.020","article-title":"Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome: results from a randomized trial","volume":"109","author":"Zhang","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib14","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(18)32843-5","article-title":"Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial","volume":"393","author":"Wei","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2019.09.047_bib15","first-page":"126","article-title":"Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles","volume":"221","author":"Ernstad","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.09.047_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bpobgyn.2011.02.006","article-title":"Placental bed disorders in preterm labor, preterm PROM, spontaneous abortion and abruptio placentae","volume":"25","author":"Romero","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2019.09.047_bib17","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1471-0528.1986.tb07830.x","article-title":"Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants","volume":"93","author":"Khong","year":"1986","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2019.09.047_bib18","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Knofler","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ajog.2019.09.047_bib19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fertnstert.2012.04.012","article-title":"Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction","volume":"98","author":"Chavarro","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib20","series-title":"Practice Committee opinion. Guidelines on number of embryos transferred","year":"1998"},{"issue":"5 Suppl","key":"10.1016\/j.ajog.2019.09.047_bib21","first-page":"S163","article-title":"Guidelines on number of embryos transferred","volume":"90","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib22","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.fertnstert.2009.08.059","article-title":"Guidelines on number of embryos transferred","volume":"92","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.fertnstert.2012.09.038","article-title":"Criteria for number of embryos to transfer: a Committee opinion","volume":"99","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib24","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam Placental Workshop Group consensus statement","volume":"140","author":"Khong","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.ajog.2019.09.047_bib25","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/15513819609168713","article-title":"Reference values for singleton and twin placental weights","volume":"16","author":"Pinar","year":"1996","journal-title":"Pediatr Pathol Lab Med"},{"key":"10.1016\/j.ajog.2019.09.047_bib26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/jmf.11.4.280.283","article-title":"The umbilical coiling index in normal pregnancy","volume":"11","author":"van Dijk","year":"2002","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2019.09.047_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10024-003-7070-y","article-title":"Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns","volume":"6","author":"Redline","year":"2003","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.ajog.2019.09.047_bib28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2350\/12-08-1243-OA.1","article-title":"Pathologic evaluation of normal and perfused term placental tissue","volume":"17","author":"Maroun","year":"2014","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.ajog.2019.09.047_bib29","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0046-8177(00)80009-X","article-title":"Chronic histiocytic intervillositis: a placental lesion associated with recurrent reproductive loss","volume":"31","author":"Boyd","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajog.2019.09.047_bib30","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/apm.12796","article-title":"Placental pathologic lesions with a significant recurrence risk\u2014what not to miss!","volume":"126","author":"Chen","year":"2018","journal-title":"APMIS"},{"key":"10.1016\/j.ajog.2019.09.047_bib31","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.humpath.2007.10.032","article-title":"Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth","volume":"39","author":"Parast","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajog.2019.09.047_bib32","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/humupd\/dmu027","article-title":"Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence","volume":"20","author":"Evans","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2019.09.047_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.fertnstert.2014.05.019","article-title":"Why we should transfer frozen instead of fresh embryos: the translational rationale","volume":"102","author":"Weinerman","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2019.09.047_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10815-014-0391-0","article-title":"Freeze-all policy: is it time for that?","volume":"32","author":"Roque","year":"2015","journal-title":"J\u00a0Assist Reprod Genet"},{"key":"10.1016\/j.ajog.2019.09.047_bib35","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10815-017-1084-2","article-title":"Difference in the size of the placenta and umbilical cord between women with natural pregnancy and those with IVF pregnancy","volume":"35","author":"Yanaihara","year":"2018","journal-title":"J\u00a0Assist Reprod Genet"},{"key":"10.1016\/j.ajog.2019.09.047_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070380","article-title":"Prevalence, risk factors and outcomes of velamentous and marginal cord insertions: a population-based study of 634,741 pregnancies","volume":"8","author":"Ebbing","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2019.09.047_bib37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejogrb.2012.08.021","article-title":"Risk factors and adverse pregnancy outcomes among births affected by velamentous umbilical cord insertion: a retrospective population-based register study","volume":"165","author":"R\u00e4is\u00e4nen","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2019.09.047_bib38","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3109\/14767058.2015.1015984","article-title":"Hypoxic ischemic encephalopathy in newborns linked to placental and umbilical cord abnormalities","volume":"29","author":"Nasiell","year":"2016","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2019.09.047_bib39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/aogs.13035","article-title":"Velamentous or marginal cord insertion and the risk of spontaneous preterm birth, prelabor rupture of the membranes, and anomalous cord length, a population-based study","volume":"96","author":"Ebbing","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2019.09.047_bib40","series-title":"Pathlogy of the human placenta","author":"Benirschke","year":"2012"},{"key":"10.1016\/j.ajog.2019.09.047_bib41","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1080\/14767058.2016.1174682","article-title":"The effect of first trimester subchorionic hematoma on pregnancy outcomes in patients underwent IVF\/ICSI treatment","volume":"30","author":"Zhou","year":"2017","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2019.09.047_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111676","article-title":"Symptoms of an intrauterine hematoma associated with pregnancy complications: a systematic review","volume":"9","author":"Xiang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2019.09.047_bib43","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.5858\/arpa.2017-0212-RA","article-title":"Fetal vascular malperfusion","volume":"141","author":"Heider","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.ajog.2019.09.047_bib44","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/apm.12849","article-title":"Fetal vascular malperfusion, an update","volume":"126","author":"Redline","year":"2018","journal-title":"APMIS"},{"key":"10.1016\/j.ajog.2019.09.047_bib45","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/AOG.0000000000002264","article-title":"Maternal vascular malperfusion and adverse perinatal outcomes in low-risk nulliparous women","volume":"130","author":"Wright","year":"2017","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.09.047_bib46","first-page":"59","article-title":"Fresh versus frozen embryo transfer for full-term singleton birth: a retrospective cohort study","volume":"11","author":"Zhang","year":"2018","journal-title":"J\u00a0Ovarian Res"},{"key":"10.1016\/j.ajog.2019.09.047_bib47","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/humrep\/det440","article-title":"Large baby syndrome in singletons born after frozen embryo transfer (FET): is it due to maternal factors or the cryotechnique?","volume":"29","author":"Pinborg","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2019.09.047_bib48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13148-017-0379-6","article-title":"Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer","volume":"9","author":"Hiura","year":"2017","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.ajog.2019.09.047_bib49","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1007\/s10815-018-1244-z","article-title":"Superovulation alters the expression of endometrial genes critical to tissue remodeling and placentation","volume":"35","author":"Senapati","year":"2018","journal-title":"J\u00a0Assist Reprod Genet"},{"key":"10.1016\/j.ajog.2019.09.047_bib50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/molehr\/gah150","article-title":"Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles","volume":"11","author":"Horcajadas","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ajog.2019.09.047_bib51","series-title":"Vivelle-Dot (Estrogen Transdermal System) [package insert]","year":"2019"},{"key":"10.1016\/j.ajog.2019.09.047_bib52","doi-asserted-by":"crossref","first-page":"E677","DOI":"10.1152\/ajpendo.00225.2019","article-title":"Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women","volume":"317","author":"Conrad","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajog.2019.09.047_bib53","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/HYPERTENSIONAHA.118.12046","article-title":"Absent or excessive corpus luteum number is associated with altered maternal vascular health in early pregnancy","volume":"73","author":"von Versen-H\u00f6ynck","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2019.09.047_bib54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.semnephrol.2010.10.003","article-title":"Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia","volume":"31","author":"Conrad","year":"2011","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.ajog.2019.09.047_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007787","article-title":"FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation","volume":"14","author":"Vasquez","year":"2018","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ajog.2019.09.047_bib56","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1152\/ajpregu.00239.2012","article-title":"Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies","volume":"304","author":"Conrad","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293781931213X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293781931213X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:28:14Z","timestamp":1757590094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293781931213X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S000293781931213X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2019.09.047","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placental pathology in live births conceived with in\u00a0vitro fertilization after fresh and frozen embryo transfer","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2019.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}