{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:46:18Z","timestamp":1792046778707,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.ajog.2019.11.1286","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T02:10:22Z","timestamp":1575943822000},"page":"497.e1-497.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Early-onset preeclampsia, plasma microRNAs, and endothelial cell function"],"prefix":"10.1016","volume":"222","author":[{"given":"Simone V.","family":"Lip","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark V.","family":"Boekschoten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido J.","family":"Hooiveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00eblle G.","family":"van Pampus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicco A.","family":"Scherjon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Pl\u00f6sch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke M.","family":"Faas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2019.11.1286_bib1","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.preghy.2018.08.068","article-title":"103. Dysregulated circulating microRNAs in preeclampsia: The role of miR-574-5p and miR-1972 in endothelial dysfunction","volume":"13","author":"Lip","year":"2018","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ajog.2019.11.1286_bib2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2019.11.1286_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.placenta.2008.11.021","article-title":"Placental stress and pre-eclampsia: a revised view","volume":"30","author":"Redman","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2019.11.1286_bib4","doi-asserted-by":"crossref","first-page":"S9.e1","DOI":"10.1016\/j.ajog.2015.08.003","article-title":"Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity","volume":"213","author":"Redman","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2019.11.1286_bib6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.placenta.2004.11.007","article-title":"Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction","volume":"27","author":"Goswami","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2019.11.1286_bib7","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1161\/HYPERTENSIONAHA.119.12707","article-title":"Placental syncytiotrophoblast-derived extracellular vesicles carry active NEP (neprilysin) and are increased in preeclampsia","volume":"73","author":"Gill","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2019.11.1286_bib8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0002-9378(99)70325-X","article-title":"Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia","volume":"181","author":"Rinehart","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","article-title":"Preeclampsia: an excessive maternal inflammatory response to pregnancy","volume":"180","author":"Redman","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib10","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/0002-9378(89)90665-0","article-title":"Preeclampsia: an endothelial cell disorder","volume":"161","author":"Roberts","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib11","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1038\/s41598-017-06178-z","article-title":"Endothelial dysfunction in severe preeclampsia is mediated by soluble factors, rather than extracellular vesicles","volume":"7","author":"O\u2019Brien","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajog.2019.11.1286_bib12","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1681\/ASN.2007020255","article-title":"The glomerular injury of preeclampsia","volume":"18","author":"Stillman","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ajog.2019.11.1286_bib14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bone.2013.07.007","article-title":"MicroRNA-124 regulates osteoclast differentiation","volume":"56","author":"Lee","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.ajog.2019.11.1286_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm.3487","article-title":"MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1","volume":"20","author":"Schober","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.ajog.2019.11.1286_bib16","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajog.2019.11.1286_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003694","article-title":"Detection of microRNA expression in human peripheral blood microvesicles","volume":"3","author":"Hunter","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2019.11.1286_bib18","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res"},{"key":"10.1016\/j.ajog.2019.11.1286_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2010.06.010","article-title":"Secreted monocytic miR-150 enhances targeted endothelial cell migration","volume":"39","author":"Zhang","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajog.2019.11.1286_bib20","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.atherosclerosis.2010.12.024","article-title":"Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration","volume":"215","author":"Zhu","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ajog.2019.11.1286_bib21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.115.306300","article-title":"MicroRNA regulation of atherosclerosis","volume":"118","author":"Feinberg","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.ajog.2019.11.1286_bib22","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1038\/s41598-019-41101-8","article-title":"Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients","volume":"9","author":"Fourdinier","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajog.2019.11.1286_bib23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1530\/REP-11-0304","article-title":"Circulating microRNAs are elevated in plasma from severe preeclamptic pregnancies","volume":"143","author":"Wu","year":"2012","journal-title":"Reproduction"},{"key":"10.1016\/j.ajog.2019.11.1286_bib24","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3892\/br.2016.779","article-title":"Dysregulated circulating miRNAs in preeclampsia","volume":"5","author":"Munaut","year":"2016","journal-title":"Biomed Rep"},{"key":"10.1016\/j.ajog.2019.11.1286_bib25","doi-asserted-by":"crossref","first-page":"970265","DOI":"10.1155\/2013\/970265","article-title":"Maternal plasma miRNAs expression in preeclamptic pregnancies","volume":"2013","author":"Li","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ajog.2019.11.1286_bib26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tjog.2014.03.001","article-title":"Potential role of circulating microRNAs as early markers of preeclampsia","volume":"53","author":"Ura","year":"2014","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib27","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.gene.2017.07.010","article-title":"Circulating microRNA expression as predictor of preeclampsia and its severity","volume":"627","author":"Jairajpuri","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.ajog.2019.11.1286_bib28","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1089\/ten.tec.2011.0150","article-title":"A\u00a0comparison of methods for quantifying angiogenesis in the Matrigel assay in\u00a0vitro","volume":"17","author":"Khoo","year":"2011","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.ajog.2019.11.1286_bib29","doi-asserted-by":"crossref","first-page":"36992","DOI":"10.1038\/srep36992","article-title":"Effects of endothelial cell proliferation and migration rates in a computational model of sprouting angiogenesis","volume":"6","author":"Norton","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajog.2019.11.1286_bib30","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/cam.36224","article-title":"An introduction to the wound healing assay using live-cell microscopy","volume":"8","author":"Jonkman","year":"2014","journal-title":"Cell Adh Migr"},{"key":"10.1016\/j.ajog.2019.11.1286_bib31","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/bioinformatics\/btl664","article-title":"Quick calculation for sample size while controlling false discovery rate with application to microarray analysis","volume":"23","author":"Liu","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajog.2019.11.1286_bib32","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1097\/AOG.0000000000003020","article-title":"ACOG Practice Bulletin No. 203","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jsgi.2004.10.014","article-title":"Plasma factors in severe early-onset preeclampsia do not substantially alter endothelial gene expression in\u00a0vitro","volume":"12","author":"Donker","year":"2005","journal-title":"J\u00a0Soc Gynecol Investig"},{"key":"10.1016\/j.ajog.2019.11.1286_bib34","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007515","article-title":"MiR-210 and miR-155 as potential diagnostic markers for pre-eclampsia pregnancies","volume":"96","author":"Gan","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ajog.2019.11.1286_bib35","first-page":"3083","article-title":"Screening for preeclampsia pathogenesis related genes","volume":"17","author":"Yan","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.ajog.2019.11.1286_bib36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2012.11.001","article-title":"Pregnancy-associated miRNA-clusters","volume":"97","author":"Morales-Prieto","year":"2013","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib37","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1097-0320(19971101)29:3<233::AID-CYTO6>3.0.CO;2-C","article-title":"Analysis of cell cycle-related Ki-67 and p120 expression by flow cytometric BrdUrd-Hoechst\/7AAD and immunolabeling technique","volume":"29","author":"Endl","year":"1997","journal-title":"Cytometry"},{"key":"10.1016\/j.ajog.2019.11.1286_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016509","article-title":"MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets","volume":"6","author":"Garbacki","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2019.11.1286_bib39","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1002\/jcb.26142","article-title":"LncRNA PTCSC3\/miR-574-5p governs cell proliferation and migration of papillary thyroid carcinoma via Wnt\/\u03b2-catenin signaling","volume":"118","author":"Wang","year":"2017","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.ajog.2019.11.1286_bib40","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1074\/jbc.R800055200","article-title":"New roles for copper metabolism in cell proliferation, signaling, and disease","volume":"284","author":"Turski","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ajog.2019.11.1286_bib41","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.ajog.2019.11.1286_bib42","doi-asserted-by":"crossref","first-page":"32493","DOI":"10.1038\/srep32493","article-title":"Identification and functional characterization of the miRNA-gene regulatory network in chronic myeloid leukemia lineage negative cells","volume":"6","author":"Agatheeswaran","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajog.2019.11.1286_bib43","first-page":"1390","article-title":"MicroRNA and gene expression changes in unruptured human cerebral aneurysms","volume":"125","author":"Bekelis","year":"2016","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.ajog.2019.11.1286_bib44","first-page":"1","article-title":"Microarray analysis and detection of MicroRNAs associated with chronic thromboembolic pulmonary hypertension","volume":"2017","author":"Miao","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ajog.2019.11.1286_bib45","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3324\/haematol.2011.048132","article-title":"MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response","volume":"97","author":"Wang","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.ajog.2019.11.1286_bib46","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1158\/1078-0432.CCR-11-1699","article-title":"MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer","volume":"18","author":"Migliore","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajog.2019.11.1286_bib47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4049\/jimmunol.1101563","article-title":"BLIMP-1 and STAT3 counterregulate MicroRNA-21 during plasma cell differentiation","volume":"189","author":"Barnes","year":"2012","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib48","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1471-0528.2012.03311.x","article-title":"Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis","volume":"119","author":"Kleinrouweler","year":"2012","journal-title":"BJOG An Int J Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib49","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/2229-3485.179431","article-title":"MicroRNA therapeutics: Discovering novel targets and developing specific therapy","volume":"7","author":"Christopher","year":"2016","journal-title":"Perspect Clin Res"},{"key":"10.1016\/j.ajog.2019.11.1286_bib50","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.ajog.2019.11.1286_bib51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/bs.acr.2017.06.006","article-title":"Animal Models to Study MicroRNA Function","volume":"135","author":"Pal","year":"2017","journal-title":"Adv Cancer Res"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937819327255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937819327255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:27:45Z","timestamp":1757590065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937819327255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0002937819327255"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2019.11.1286","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early-onset preeclampsia, plasma microRNAs, and endothelial cell function","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2019.11.1286","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}