{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:37:28Z","timestamp":1792406248825,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006407","name":"American Water Works Association Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ajog.2020.07.012","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T01:38:18Z","timestamp":1594604298000},"page":"97.e1-97.e16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Week-by-week alcohol consumption in early pregnancy and spontaneous abortion risk: a prospective cohort study"],"prefix":"10.1016","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-5539","authenticated-orcid":false,"given":"Alexandra C.","family":"Sundermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digna R.","family":"Velez Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Slaughter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingsheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Torstenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2020.07.012_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.15585\/mmwr.mm6504a6","article-title":"Vital signs: alcohol-exposed pregnancies\u2014United States, 2011-2013","volume":"65","author":"Green","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.ajog.2020.07.012_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/acer.13305","article-title":"Prenatal alcohol consumption between conception and recognition of pregnancy","volume":"41","author":"McCormack","year":"2017","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajog.2020.07.012_bib3","doi-asserted-by":"crossref","first-page":"e006323","DOI":"10.1136\/bmjopen-2014-006323","article-title":"Prevalence and predictors of alcohol use during pregnancy: findings from international multicentre cohort studies","volume":"5","author":"O\u2019Keeffe","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.ajog.2020.07.012_bib4","doi-asserted-by":"crossref","first-page":"e290","DOI":"10.1016\/S2214-109X(17)30021-9","article-title":"Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis","volume":"5","author":"Popova","year":"2017","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.ajog.2020.07.012_bib5","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.15585\/mmwr.mm6437a3","article-title":"Alcohol use and binge drinking among women of childbearing age - United States, 2011-2013","volume":"64","author":"Tan","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.ajog.2020.07.012_bib6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/AOG.0000000000001933","article-title":"Pregnancy intention and maternal alcohol consumption","volume":"129","author":"Pryor","year":"2017","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2020.07.012_bib7","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1111\/acer.14124","article-title":"Alcohol use in pregnancy and miscarriage: a systematic review and meta-analysis","volume":"43","author":"Sundermann","year":"2019","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajog.2020.07.012_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/1471-2393-14-246","article-title":"Factors influencing women\u2019s decisions to drink alcohol during pregnancy: findings of a qualitative study with implications for health communication","volume":"14","author":"Meurk","year":"2014","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.ajog.2020.07.012_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/13698575.2016.1166186","article-title":"\u2018I\u2019m not clear on what the risk is\u2019: women\u2019s reflexive negotiations of uncertainty about alcohol during pregnancy","volume":"18","author":"Holland","year":"2016","journal-title":"Health Risk Soc"},{"key":"10.1016\/j.ajog.2020.07.012_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/bdra.23014","article-title":"A\u00a0systematic review to calculate background miscarriage rates using life table analysis","volume":"94","author":"Ammon Avalos","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ajog.2020.07.012_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198807283190401","article-title":"Incidence of early loss of pregnancy","volume":"319","author":"Wilcox","year":"1988","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2020.07.012_bib12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/humupd\/dmy025","article-title":"The psychological impact of early pregnancy loss","volume":"24","author":"Farren","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2020.07.012_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1139\/bcb-2017-0133","article-title":"Detrimental effects of alcohol exposure around conception: putative mechanisms","volume":"96","author":"Kalisch-Smith","year":"2018","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.ajog.2020.07.012_bib14","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/aje\/kwy267","article-title":"Gestational age at arrest of development: an alternative approach for assigning time at risk in studies of time-varying exposures and miscarriage","volume":"188","author":"Sundermann","year":"2019","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajog.2020.07.012_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-3016.2003.00546.x","article-title":"Recruitment for a community-based study of early pregnancy: the Right From The Start study","volume":"18","author":"Promislow","year":"2004","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.ajog.2020.07.012_bib16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-3016.2008.00965.x","article-title":"Comparison of gestational age at birth based on last menstrual period and ultrasound during the first trimester","volume":"22","author":"Hoffman","year":"2008","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.ajog.2020.07.012_bib17","series-title":"The developing human: clinically oriented embryology","author":"Moore","year":"2015"},{"key":"10.1016\/j.ajog.2020.07.012_bib18","series-title":"Statistical modeling for biomedical researchers: a simple introduction to the analysis of complex data","author":"Dupont","year":"2009"},{"key":"10.1016\/j.ajog.2020.07.012_bib19","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.15288\/jsa.1981.42.1030","article-title":"Congener contents of alcoholic beverages","volume":"42","author":"Greizerstein","year":"1981","journal-title":"J\u00a0Stud Alcohol"},{"key":"10.1016\/j.ajog.2020.07.012_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00001648-199901000-00008","article-title":"Causal diagrams for epidemiologic research","volume":"10","author":"Greenland","year":"1999","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajog.2020.07.012_bib21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.contraception.2011.07.013","article-title":"Unintended pregnancy in the United States: incidence and disparities, 2006","volume":"84","author":"Finer","year":"2011","journal-title":"Contraception"},{"key":"10.1016\/j.ajog.2020.07.012_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ydbio.2004.12.014","article-title":"Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels","volume":"279","author":"Yelin","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajog.2020.07.012_bib23","first-page":"265","article-title":"Medical genetics: 1. Clinical teratology in the age of genomics","volume":"167","author":"Polifka","year":"2002","journal-title":"CMAJ"},{"key":"10.1016\/j.ajog.2020.07.012_bib24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1186\/s12889-016-3354-9","article-title":"\u201cDid you ever drink more?\u201d A detailed description of pregnant women\u2019s drinking patterns","volume":"16","author":"Muggli","year":"2016","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ajog.2020.07.012_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0749-3797(99)00059-8","article-title":"Alcohol use prior to pregnancy recognition","volume":"17","author":"Floyd","year":"1999","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.ajog.2020.07.012_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejogrb.2017.04.005","article-title":"How strong is the evidence for using blood biomarkers alone to screen for alcohol consumption during pregnancy? A systematic review","volume":"213","author":"Howlett","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2020.07.012_bib27","first-page":"86","article-title":"Prenatal alcohol exposure and miscarriage, stillbirth, preterm delivery, and sudden infant death syndrome","volume":"34","author":"Bailey","year":"2011","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.ajog.2020.07.012_bib28","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1530-0277.1988.tb00233.x","article-title":"Underreporting of alcohol use in pregnancy","volume":"12","author":"Ernhart","year":"1988","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.ajog.2020.07.012_bib29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.15288\/jsad.2016.77.272","article-title":"Monthly estimates of alcohol drinking during pregnancy: United States, 2002-2011","volume":"77","author":"Alshaarawy","year":"2016","journal-title":"J\u00a0Stud Alcohol Drugs"},{"key":"10.1016\/j.ajog.2020.07.012_bib30","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00001648-200107000-00017","article-title":"Recall bias in a case-control surveillance system on the use of medicine during pregnancy","volume":"12","author":"Rockenbauer","year":"2001","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajog.2020.07.012_bib31","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1001\/jama.290.22.2996","article-title":"Fetal alcohol spectrum disorder","volume":"290","author":"Sokol","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2020.07.012_bib32","first-page":"15","article-title":"Maternal risk factors for fetal alcohol spectrum disorders: not as simple as it might seem","volume":"34","author":"May","year":"2011","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.ajog.2020.07.012_bib33","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1001\/jamapediatrics.2017.0778","article-title":"Association between prenatal alcohol exposure and craniofacial shape of children at 12 months of age","volume":"171","author":"Muggli","year":"2017","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.ajog.2020.07.012_bib34","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.4714","article-title":"Association between prenatal exposure to alcohol and tobacco and neonatal brain activity: results from the Safe Passage Study","volume":"3","author":"Shuffrey","year":"2020","journal-title":"JAMA Netw Open"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937820307250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937820307250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:32:00Z","timestamp":1757590320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937820307250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0002937820307250"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2020.07.012","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Week-by-week alcohol consumption in early pregnancy and spontaneous abortion risk: a prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2020.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}