{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:19:34Z","timestamp":1788466774063,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K09760"],"award-info":[{"award-number":["19K09760"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19lk1403022h0002"],"award-info":[{"award-number":["19lk1403022h0002"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18lk14030XXh0002"],"award-info":[{"award-number":["18lk14030XXh0002"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.ajog.2020.09.010","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T23:41:11Z","timestamp":1599867671000},"page":"398.e1-398.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of resuscitative infusion with hemoglobin vesicles in rabbits with massive obstetric hemorrhage"],"prefix":"10.1016","volume":"224","author":[{"given":"Yukako","family":"Yuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-4570","authenticated-orcid":false,"given":"Kohsuke","family":"Hagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouki","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizoh","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuo","family":"Terui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2020.09.010_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aan.2017.07.004","article-title":"Obstetric hemorrhage: prevention, recognition, and treatment","volume":"35","author":"Papazian","year":"2017","journal-title":"Adv Anesth"},{"key":"10.1016\/j.ajog.2020.09.010_bib2","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1016\/j.wombi.2016.11.003","article-title":"Factors contributing to postpartum blood-loss in low-risk mothers through expectant management in Japanese birth centres","volume":"30","author":"Eto","year":"2017","journal-title":"Women Birth"},{"key":"10.1016\/j.ajog.2020.09.010_bib3","first-page":"112","article-title":"Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement","volume":"17","author":"Mu\u00f1oz","year":"2019","journal-title":"Blood Transfus"},{"key":"10.1016\/j.ajog.2020.09.010_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ajog.2015.08.068","article-title":"An update on the use of massive transfusion protocols in obstetrics","volume":"214","author":"Pacheco","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2020.09.010_bib5","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbapap.2008.03.007","article-title":"NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers","volume":"1784","author":"Sakai","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajog.2020.09.010_bib6","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1124\/dmd.109.027094","article-title":"Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin vesicles as an artificial oxygen carrier","volume":"37","author":"Taguchi","year":"2009","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.ajog.2020.09.010_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/jfb8010010","article-title":"Overview of potential clinical applications of hemoglobin vesicles (HbV) as artificial red cells, evidenced by preclinical studies of the Academic Research Consortium","volume":"8","author":"Sakai","year":"2017","journal-title":"J\u00a0Funct Biomater"},{"key":"10.1016\/j.ajog.2020.09.010_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/SHK.0b013e31825ad7cf","article-title":"Effect of the cellular-type artificial oxygen carrier hemoglobin vesicle as a resuscitative fluid for prehospital treatment: experiments in a rat uncontrolled hemorrhagic shock model","volume":"38","author":"Seishi","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.ajog.2020.09.010_bib9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/SHK.0000000000001042","article-title":"Efficacy of resuscitative transfusion with hemoglobin vesicles in the treatment of massive hemorrhage in rabbits with thrombocytopenic coagulopathy and its effect on hemostasis by platelet transfusion","volume":"50","author":"Hagisawa","year":"2018","journal-title":"Shock"},{"key":"10.1016\/j.ajog.2020.09.010_bib10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/SHK.0b013e318188f83d","article-title":"Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model","volume":"31","author":"Sakai","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.ajog.2020.09.010_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165557","article-title":"Long-term stored hemoglobin-vesicles, a cellular type of hemoglobin-based oxygen carrier, has resuscitative effects comparable to that for fresh red blood cells in a rat model with massive hemorrhage without post-transfusion lung injury","volume":"11","author":"Tokuno","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2020.09.010_bib12","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.resuscitation.2009.08.024","article-title":"Increased survival with hypotensive resuscitation in a rabbit model of uncontrolled hemorrhagic shock in pregnancy","volume":"80","author":"Yu","year":"2009","journal-title":"Resuscitation"},{"key":"10.1016\/j.ajog.2020.09.010_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jss.2009.09.007","article-title":"Hypotensive resuscitation combined with polydatin improve microcirculation and survival in a rabbit model of uncontrolled hemorrhagic shock in pregnancy","volume":"168","author":"Sheng","year":"2011","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.ajog.2020.09.010_bib14","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/1471-0528.12531","article-title":"Transfusion policy after severe postpartum haemorrhage: a randomised non-inferiority trial","volume":"121","author":"Prick","year":"2014","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2020.09.010_bib15","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1186\/s13104-018-3800-0","article-title":"Haemoglobin concentration following postpartum haemorrhage and the association between blood transfusion and breastfeeding: a retrospective cohort study","volume":"11","author":"Chessman","year":"2018","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.ajog.2020.09.010_bib16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/bja\/aen321","article-title":"Supplementary oxygen for emergency caesarean section under regional anaesthesia","volume":"102","author":"Khaw","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ajog.2020.09.010_bib17","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00000539-200107000-00029","article-title":"Fetal oxygen content is restored after maternal hemorrhage and fluid replacement with polymerized bovine hemoglobin, but not with hetastarch, in pregnant sheep","volume":"93","author":"Moon","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ajog.2020.09.010_bib18","first-page":"45","article-title":"Baseline serum bicarbonate levels independently predict short-term mortality in critically ill patients with ischaemic cardiogenic shock","volume":"7","author":"Wigger","year":"2018","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.ajog.2020.09.010_bib19","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.2337\/dc06-9916","article-title":"Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association","volume":"29","author":"Kitabchi","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ajog.2020.09.010_bib20","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1111\/trf.15427","article-title":"Combination therapy using fibrinogen \u03b3-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits","volume":"59","author":"Hagisawa","year":"2019","journal-title":"Transfusion"},{"key":"10.1016\/j.ajog.2020.09.010_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.redox.2012.12.003","article-title":"Is methemoglobin an inert bystander, biomarker or a mediator of oxidative stress--the example of anemia?","volume":"1","author":"Hare","year":"2013","journal-title":"Redox Biol"},{"key":"10.1016\/j.ajog.2020.09.010_bib22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/CIRCULATIONAHA.110.008698","article-title":"Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion","volume":"124","author":"Donadee","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ajog.2020.09.010_bib23","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1074\/jbc.M707660200","article-title":"Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO, by intracellular diffusion barrier","volume":"283","author":"Sakai","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ajog.2020.09.010_bib24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/01.CCM.0000109774.99665.22","article-title":"Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats","volume":"32","author":"Sakai","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajog.2020.09.010_bib25","first-page":"4","article-title":"A\u00a0fourteen-day observation and pharmacokinetic evaluation after a massive intravenous infusion of hemoglobin-vesicles (artificial oxygen carriers) in cynomolgus monkeys","volume":"3","author":"Taguchi","year":"2012","journal-title":"J\u00a0Drug Metab Toxicol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293782031067X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293782031067X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:55:44Z","timestamp":1788465344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293782031067X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S000293782031067X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2020.09.010","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of resuscitative infusion with hemoglobin vesicles in rabbits with massive obstetric hemorrhage","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2020.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}