{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:14:05Z","timestamp":1784675645521,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"am","delay-in-days":361,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ajog.2021.06.051","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:35:05Z","timestamp":1623458105000},"page":"662.e1-662.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Chronic histiocytic intervillositis: manifestation of placental alloantibody-mediated rejection"],"prefix":"10.1016","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-0765","authenticated-orcid":false,"given":"Alexandra","family":"Benachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Rabant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Martinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanane","family":"Bouchghoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre J.","family":"Vivanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Grunenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubka","family":"Roumenina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Celton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Bessieres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Taupin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Zuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2021.06.051_bib1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nri1897","article-title":"Immunology of placentation in eutherian mammals","volume":"6","author":"Moffett","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajog.2021.06.051_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0165-0378(01)00115-2","article-title":"Transcriptional control of MHC genes in fetal trophoblast cells","volume":"52","author":"van den Elsen","year":"2001","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ajog.2021.06.051_bib3","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1172\/JCI68107","article-title":"Uterine NK cells: active regulators at the maternal-fetal interface","volume":"124","author":"Moffett","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2021.06.051_bib4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/apm.12796","article-title":"Placental pathologic lesions with a significant recurrence risk - what not to miss!","volume":"126","author":"Chen","year":"2018","journal-title":"APMIS"},{"issue":"Suppl4","key":"10.1016\/j.ajog.2021.06.051_bib5","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.ajog.2015.08.041","article-title":"Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance","volume":"213","author":"Kim","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.06.051_bib6","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0046-8177(00)80009-X","article-title":"Chronic histiocytic intervillositis: a placental lesion associated with recurrent reproductive loss","volume":"31","author":"Boyd","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajog.2021.06.051_bib7","series-title":"Practical manual of fetal pathology","first-page":"135","article-title":"Placenta","author":"Redline","year":"2021"},{"key":"10.1016\/j.ajog.2021.06.051_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejogrb.2008.06.012","article-title":"Chronic intervillositis of unknown etiology (CIUE): relation between placental lesions and perinatal outcome","volume":"143","author":"Parant","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2021.06.051_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/aji.12143","article-title":"Maternal floor infarction\/massive perivillous fibrin deposition: a manifestation of maternal antifetal rejection?","volume":"70","author":"Romero","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2021.06.051_bib10","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1515\/jpm-2017-0073","article-title":"Fetal death: an extreme manifestation of maternal anti-fetal rejection","volume":"45","author":"Lannaman","year":"2017","journal-title":"J\u00a0Perinat Med"},{"key":"10.1016\/j.ajog.2021.06.051_bib11","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1056\/NEJMra1802677","article-title":"Antibody-mediated rejection of solid-organ allografts","volume":"379","author":"Loupy","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2021.06.051_bib12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/ajt.14625","article-title":"The Banff 2017 Kidney Meeting Report: revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials","volume":"18","author":"Haas","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajog.2021.06.051_bib13","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1681\/ASN.2009101065","article-title":"Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation","volume":"21","author":"Lefaucheur","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ajog.2021.06.051_bib14","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1600-6143.2009.02985.x","article-title":"Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantation","volume":"10","author":"Gloor","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajog.2021.06.051_bib15","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa1302506","article-title":"Complement-binding anti-HLA antibodies and kidney-allograft survival","volume":"369","author":"Loupy","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2021.06.051_bib16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0198-8859(02)00382-8","article-title":"HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. I. Description of the algorithm","volume":"63","author":"Duquesnoy","year":"2002","journal-title":"Hum Immunol"},{"key":"10.1016\/j.ajog.2021.06.051_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.placenta.2010.10.008","article-title":"Placenta weight percentile curves for singleton and twins deliveries","volume":"32","author":"Almog","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2021.06.051_bib18","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/ajt.12048","article-title":"Frequency and determinants of pregnancy-induced child-specific sensitization","volume":"13","author":"H\u00f6nger","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajog.2021.06.051_bib19","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1681\/ASN.V10102208","article-title":"Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries","volume":"10","author":"Collins","year":"1999","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ajog.2021.06.051_bib20","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.4049\/jimmunol.1901297","article-title":"Maternal T cells in the human placental villi support an allograft response during noninfectious villitis","volume":"204","author":"Enninga","year":"2020","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.ajog.2021.06.051_bib21","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1002\/ajmg.a.37856","article-title":"Recurrent chronic histiocytic intervillositis with intrauterine growth restriction, osteopenia, and fractures","volume":"170","author":"Crawford","year":"2016","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajog.2021.06.051_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/uog.22134","article-title":"ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction","volume":"56","author":"Lees","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.06.051_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/aji.12141","article-title":"Detection of anti-HLA antibodies in maternal blood in the second trimester to identify patients at risk of antibody-mediated maternal anti-fetal rejection and spontaneous preterm delivery","volume":"70","author":"Lee","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2021.06.051_bib24","doi-asserted-by":"crossref","first-page":"e16806","DOI":"10.1371\/journal.pone.0016806","article-title":"A\u00a0signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2021.06.051_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2350\/12-05-1195-OA.1","article-title":"Positive C4d immunostaining of placental villous syncytiotrophoblasts supports host-versus-graft rejection in villitis of unknown etiology","volume":"16","author":"Rudzinski","year":"2013","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.ajog.2021.06.051_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.placenta.2017.11.012","article-title":"Towards standardized criteria for diagnosing chronic intervillositis of unknown etiology: a systematic review","volume":"61","author":"Bos","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2021.06.051_bib27","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1111\/ajt.15177","article-title":"HLA-DR\/DQ molecular mismatch: a prognostic biomarker for primary alloimmunity","volume":"19","author":"Wiebe","year":"2019","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajog.2021.06.051_bib28","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1111\/ajt.15937","article-title":"Sensitization in transplantation: assessment of risk (STAR) 2019 Working Group Meeting Report","volume":"20","author":"Tambur","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajog.2021.06.051_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/clinchem\/hvaa304","article-title":"Forever connected: the lifelong biological consequences of fetomaternal and maternofetal microchimerism","volume":"67","author":"Bianchi","year":"2021","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajog.2021.06.051_bib30","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.humimm.2013.04.025","article-title":"Incidence and risk factors of anti-HLA immunization after pregnancy","volume":"74","author":"Masson","year":"2013","journal-title":"Hum Immunol"},{"key":"10.1016\/j.ajog.2021.06.051_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-6143.2008.02461.x","article-title":"Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production","volume":"9","author":"Perry","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajog.2021.06.051_bib32","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1097\/01.ASN.0000145878.92906.9F","article-title":"Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: report of the NIH IG02 trial","volume":"15","author":"Jordan","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ajog.2021.06.051_bib33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41581-018-0039-x","article-title":"HLA in transplantation","volume":"14","author":"Montgomery","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ajog.2021.06.051_bib34","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.1220030","article-title":"Chemokine gene silencing in decidual tromal cells limits T cell access to the maternal-fetal interface","volume":"336","author":"Nancy","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ajog.2021.06.051_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1172\/JCI95937","article-title":"H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition","volume":"128","author":"Nancy","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2021.06.051_bib36","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1681\/ASN.2014080797","article-title":"Urinary C\u2013X-C motif chemokine 10 independently improves the noninvasive diagnosis of antibody-mediated kidney allograft rejection","volume":"26","author":"Rabant","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ajog.2021.06.051_bib37","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1681\/ASN.V133779","article-title":"Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification","volume":"13","author":"Mauiyyedi","year":"2002","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ajog.2021.06.051_bib38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1172\/JCI93542","article-title":"Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection","volume":"128","author":"Chen","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2021.06.051_bib39","first-page":"2580","article-title":"Antibody-mediated rejection of solid organ allografts","volume":"379","author":"Lefaucheur","year":"2018","journal-title":"N\u00a0Engl J Med"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937821006840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937821006840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:35:36Z","timestamp":1762079736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937821006840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0002937821006840"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2021.06.051","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic histiocytic intervillositis: manifestation of placental alloantibody-mediated rejection","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2021.06.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}