{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:58:21Z","timestamp":1787590701286,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD092515"],"award-info":[{"award-number":["R01 HD092515"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ajog.2021.11.1353","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T10:49:50Z","timestamp":1637232590000},"page":"708.e1-708.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mechanisms governing protective pregnancy-induced adaptations of the pelvic floor muscles in the rat preclinical model"],"prefix":"10.1016","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4126-5200","authenticated-orcid":false,"given":"Mary M.","family":"Rieger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-7475","authenticated-orcid":false,"given":"Michelle","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey A.","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5777-5657","authenticated-orcid":false,"given":"Francesca Boscolo","family":"Sesillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittni B.","family":"Baynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Alperin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2021.11.1353_bib1","first-page":"446","article-title":"Pelvic organ prolapse - a review","volume":"44","author":"Dietz","year":"2015","journal-title":"Aust Fam Physician"},{"key":"10.1016\/j.ajog.2021.11.1353_bib2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00192-017-3314-7","article-title":"Clinical epidemiological insights into urinary incontinence","volume":"28","author":"Minassian","year":"2017","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.ajog.2021.11.1353_bib3","doi-asserted-by":"crossref","first-page":"198.e1","DOI":"10.1016\/j.ajog.2008.04.027","article-title":"Quantity and distribution of levator ani stretch during simulated vaginal childbirth","volume":"199","author":"Hoyte","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/01.AOG.0000109207.22354.65","article-title":"Levator ani muscle stretch induced by simulated vaginal birth","volume":"103","author":"Lien","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1113\/jphysiol.1995.sp020980","article-title":"Injury to muscle fibres after single stretches of passive and maximally stimulated muscles in mice","volume":"488","author":"Brooks","year":"1995","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ogc.2015.10.008","article-title":"The epidemiology of\u00a0pelvic floor disorders and childbirth: an update","volume":"43","author":"Hallock","year":"2016","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.ajog.2021.11.1353_bib7","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/1097-4598(200011)23:11<1647::AID-MUS1>3.0.CO;2-M","article-title":"Functional and clinical significance of skeletal muscle architecture","volume":"23","author":"Lieber","year":"2000","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ajog.2021.11.1353_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0006-3495(90)82524-8","article-title":"New insights into the behavior of muscle during active lengthening","volume":"57","author":"Morgan","year":"1990","journal-title":"Biophys J"},{"key":"10.1016\/j.ajog.2021.11.1353_bib9","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1038\/s41598-018-27239-x","article-title":"Regulation of extracellular matrix elements and sarcomerogenesis in response to different periods of passive stretching in the\u00a0soleus muscle of rats","volume":"8","author":"Peviani","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajog.2021.11.1353_bib10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/jor.1100170415","article-title":"Muscle regeneration and fiber-type transformation during distraction osteogenesis","volume":"17","author":"De Deyne","year":"1999","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.ajog.2021.11.1353_bib11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00031.2003","article-title":"Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading","volume":"84","author":"Kjaer","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajog.2021.11.1353_bib12","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI119003","article-title":"Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells","volume":"98","author":"Yasuda","year":"1996","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2021.11.1353_bib13","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s00192-014-2423-9","article-title":"Comparison of pelvic muscle architecture between humans and commonly used laboratory species","volume":"25","author":"Alperin","year":"2014","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.ajog.2021.11.1353_bib14","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00192-017-3303-x","article-title":"Architectural assessment of rhesus macaque pelvic floor muscles: comparison for use as a human model","volume":"28","author":"Stewart","year":"2017","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.ajog.2021.11.1353_bib15","first-page":"517","article-title":"Development of posture in the rat","volume":"53","author":"Geisler","year":"1993","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"10.1016\/j.ajog.2021.11.1353_bib16","doi-asserted-by":"crossref","first-page":"E308","DOI":"10.1097\/00007632-200107150-00006","article-title":"A\u00a0comparison between bipedal and quadrupedal rats: do bipedal rats actually assume an upright posture?","volume":"26","author":"Bailey","year":"2001","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.ajog.2021.11.1353_bib17","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00192-010-1149-6","article-title":"Pregnancy- and delivery-induced biomechanical changes in rat vagina persist postpartum","volume":"21","author":"Alperin","year":"2010","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.ajog.2021.11.1353_bib18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/01.AOG.0000250472.96672.6c","article-title":"Biomechanical adaptations of the rat vagina and supportive tissues in pregnancy to accommodate delivery","volume":"109","author":"Lowder","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/01.AOG.0000246798.78839.62","article-title":"Adaptations of the rat vagina in pregnancy to accommodate delivery","volume":"109","author":"Daucher","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib20","doi-asserted-by":"crossref","first-page":"191.e1","DOI":"10.1016\/j.ajog.2015.05.012","article-title":"Pregnancy-induced adaptations in the intrinsic structure of rat pelvic floor muscles","volume":"213","author":"Alperin","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib21","doi-asserted-by":"crossref","first-page":"512.e1","DOI":"10.1016\/j.ajog.2018.02.001","article-title":"Pelvic muscles\u2019 mechanical response to strains in the absence and presence of pregnancy-induced adaptations in a rat model","volume":"218","author":"Catanzarite","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib22","doi-asserted-by":"crossref","first-page":"210.e1","DOI":"10.1016\/j.ajog.2016.02.018","article-title":"Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles","volume":"215","author":"Alperin","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib23","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/ar.a.10116","article-title":"Innervation of the levator ani and coccygeus muscles of the female rat","volume":"275","author":"Bremer","year":"2003","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib24","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0006-3495(84)84246-0","article-title":"Sarcomere length determination using laser diffraction. Effect of beam and fiber diameter","volume":"45","author":"Lieber","year":"1984","journal-title":"Biophys J"},{"key":"10.1016\/j.ajog.2021.11.1353_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0009-8981(80)90192-8","article-title":"Modified assay for determination of hydroxyproline in a tissue\u00a0hydrolyzate","volume":"104","author":"Edwards","year":"1980","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ajog.2021.11.1353_bib26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G\u2217Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.ajog.2021.11.1353_bib27","doi-asserted-by":"crossref","unstructured":"Duran P, Sesillo FB, Burnett L, et\u00a0al. Pro-regenerative extracellular matrix hydrogel prevents and mitigates pathological alterations of pelvic muscles following birth injury. bioRxiv. Preprint posted online May 28, 2021. https:\/\/doi.org\/10.1101\/2021.05.28.446170","DOI":"10.1101\/2021.05.28.446170"},{"key":"10.1016\/j.ajog.2021.11.1353_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1023\/B:JURE.0000035851.12800.39","article-title":"Effects of reduced joint mobility on sarcomere length, collagen fibril arrangement in the endomysium, and hyaluronan in rat soleus muscle","volume":"25","author":"Okita","year":"2004","journal-title":"J\u00a0Muscle Res Cell Motil"},{"key":"10.1016\/j.ajog.2021.11.1353_bib29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/jmor.1052120203","article-title":"Functional morphology of the endomysium in series fibered muscles","volume":"212","author":"Trotter","year":"1992","journal-title":"J\u00a0Morphol"},{"key":"10.1016\/j.ajog.2021.11.1353_bib30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12984-017-0318-y","article-title":"Skeletal muscle mechanics, energetics and plasticity","volume":"14","author":"Lieber","year":"2017","journal-title":"J\u00a0Neuroeng Rehabil"},{"key":"10.1016\/j.ajog.2021.11.1353_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1113\/jphysiol.1972.sp009891","article-title":"Physiological and\u00a0structural changes in the cat\u2019s soleus muscle due to immobilization at different lengths by\u00a0plaster casts","volume":"224","author":"Tabary","year":"1972","journal-title":"J\u00a0Physiol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937821025825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937821025825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:37:29Z","timestamp":1757590649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937821025825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0002937821025825"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2021.11.1353","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.01.454675","asserted-by":"object"}]},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms governing protective pregnancy-induced adaptations of the pelvic floor muscles in the rat preclinical model","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2021.11.1353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}