{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:02:55Z","timestamp":1793145775157,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1000400"],"award-info":[{"award-number":["2016YFC1000400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["BYSYDL2019001"],"award-info":[{"award-number":["BYSYDL2019001"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ajog.2021.12.021","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T19:52:39Z","timestamp":1639597959000},"page":"835.e1-835.e17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Is there a relationship between plasma, cytokine concentrations, and the subsequent risk of postpartum hemorrhage?"],"prefix":"10.1016","volume":"226","author":[{"given":"Hai","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2558-7122","authenticated-orcid":false,"given":"Yangyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2021.12.021_bib1","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: a WHO systematic analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.ajog.2021.12.021_bib2","article-title":"Obstetrics Subgroup Chinese Society of Obstetrics and Gynecology Chinese Medical Association. Guideline of prevention and treatment about postpartum hemorrhage (2014].","volume":"49","year":"2014","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.ajog.2021.12.021_bib3","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1097\/AOG.0000000000002351","article-title":"Practice Bulletin No. 183: postpartum hemorrhage","volume":"130","year":"2017","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.12.021_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ijgo.13474","article-title":"Poor uterine contractility and postpartum hemorrhage among low-risk women: a case-control study of a large-scale database from Japan","volume":"154","author":"Nishida","year":"2021","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajog.2021.12.021_bib5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/AOG.0000000000004228","article-title":"Risk factors for atonic postpartum hemorrhage: a systematic review and meta-analysis","volume":"137","author":"Ende","year":"2021","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.12.021_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-0897.2010.00858.x","article-title":"Antigen-presenting cells in pregnant and non-pregnant human myometrium","volume":"64","author":"Ivanisevic","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ajog.2021.12.021_bib7","doi-asserted-by":"crossref","first-page":"177.e15","DOI":"10.1016\/j.ajog.2010.09.025","article-title":"A\u00a0molecular signature of an arrest of descent in human parturition","volume":"204","author":"Mittal","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.12.021_bib8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1515\/jpm.2010.097","article-title":"Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term","volume":"38","author":"Mittal","year":"2010","journal-title":"J\u00a0Perinat Med"},{"key":"10.1016\/j.ajog.2021.12.021_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jri.2015.04.004","article-title":"Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology: a possible involvement of local immune reactions","volume":"110","author":"Farhana","year":"2015","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ajog.2021.12.021_bib10","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/jog.14012","article-title":"Elevated bradykinin receptor type 1 expression in postpartum acute myometritis: possible involvement in augmented interstitial edema of the atonic gravid uterus","volume":"45","author":"Shen","year":"2019","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.ajog.2021.12.021_bib11","doi-asserted-by":"crossref","first-page":"103116","DOI":"10.1016\/j.jri.2020.103116","article-title":"Acute inflammation in the uterine isthmus coincides with postpartum acute myometritis in the uterine body involving refractory postpartum hemorrhage of unknown etiology after cesarean delivery","volume":"139","author":"Jain","year":"2020","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ajog.2021.12.021_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0895-4356(00)00321-8","article-title":"Validating recommendations for coronary angiography following acute myocardial infarction in the elderly: a matched analysis using propensity scores","volume":"54","author":"Normand","year":"2001","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.ajog.2021.12.021_bib13","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/sim.3150","article-title":"A\u00a0critical appraisal of propensity-score matching in the medical literature between 1996 and 2003","volume":"27","author":"Austin","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.ajog.2021.12.021_bib14","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/EDE.0b013e318064630a","article-title":"Analysis of matched case-control data with incomplete strata: applying longitudinal approaches","volume":"18","author":"Lin","year":"2007","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajog.2021.12.021_bib15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.ajog.2021.12.021_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jri.2008.04.002","article-title":"Inflammatory processes in preterm and term parturition","volume":"79","author":"Christiaens","year":"2008","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ajog.2021.12.021_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra0904308","article-title":"The enigma of spontaneous preterm birth","volume":"362","author":"Muglia","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2021.12.021_bib18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/molehr\/gap054","article-title":"Leukocytes are primed in peripheral blood for activation during term and preterm labour","volume":"15","author":"Yuan","year":"2009","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ajog.2021.12.021_bib19","doi-asserted-by":"crossref","first-page":"70.e1","DOI":"10.1016\/j.ajog.2013.08.031","article-title":"Systemic increase in human maternal circulating CD14+CD16- MCP-1+ monocytes as a marker of labor","volume":"210","author":"Bardou","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.12.021_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/humrep\/14.1.229","article-title":"Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process","volume":"14","author":"Thomson","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2021.12.021_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1095\/biolreprod66.2.445","article-title":"Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term","volume":"66","author":"Young","year":"2002","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2021.12.021_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/molehr\/gag001","article-title":"Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term","volume":"9","author":"Osman","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ajog.2021.12.021_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/JOE-17-0318","article-title":"Is myometrial inflammation a cause or a consequence of term human labour?","volume":"235","author":"Singh","year":"2017","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.ajog.2021.12.021_bib24","doi-asserted-by":"crossref","first-page":"223.e1","DOI":"10.1016\/j.ajog.2011.01.002","article-title":"Maternal inflammation in spontaneous term labor","volume":"204","author":"Unal","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.12.021_bib25","doi-asserted-by":"crossref","first-page":"447.e1","DOI":"10.1016\/j.ajog.2013.11.038","article-title":"Maternal inflammatory markers and term labor performance","volume":"210","author":"Cierny","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.12.021_bib26","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1095\/biolreprod.110.086785","article-title":"Labor and inflammation increase the expression of oxytocin receptor in human amnion","volume":"84","author":"Terzidou","year":"2011","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2021.12.021_bib27","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1095\/biolreprod63.3.846","article-title":"Oxytocin signaling in human myometrium is impaired by prolonged exposure to interleukin-1","volume":"63","author":"Rauk","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2021.12.021_bib28","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1210\/endo.142.4.8107","article-title":"Transcriptional regulation of oxytocin receptor by interleukin-1beta and interleukin-6","volume":"142","author":"Schmid","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajog.2021.12.021_bib29","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.0001-6349.2004.00271.x","article-title":"Markedly elevated levels of inflammatory cytokines in maternal serum and peritoneal washing during arrested labor","volume":"83","author":"Abramov","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2021.12.021_bib30","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s43032-019-00114-4","article-title":"A\u00a0protein microarray analysis of plasma proteins for the prediction of spontaneous preterm delivery in women with preterm labor","volume":"27","author":"Hong","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajog.2021.12.021_bib31","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1242\/dev.051359","article-title":"Regulation of hematopoietic cell clusters in the placental niche through SCF\/Kit signaling in embryonic mouse","volume":"137","author":"Sasaki","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ajog.2021.12.021_bib32","doi-asserted-by":"crossref","first-page":"345.e1","DOI":"10.1016\/j.ajog.2017.12.234","article-title":"Comparative analysis of gene expression in maternal peripheral blood and monocytes during spontaneous preterm labor","volume":"218","author":"Paquette","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2021.12.021_bib33","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1080\/14767050802251024","article-title":"Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic, and neural cell adhesion molecule in preeclampsia","volume":"21","author":"Ozkan","year":"2008","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2021.12.021_bib34","doi-asserted-by":"crossref","first-page":"663044","DOI":"10.3389\/fphar.2021.663044","article-title":"Fibroblast growth factor type 2 (FGF2) administration attenuated the clinical manifestations of preeclampsia in a murine model induced by\u00a0L-NAME","volume":"12","author":"Martinez-Fierro","year":"2021","journal-title":"Front Pharmacol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937821026818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937821026818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:37:32Z","timestamp":1757590652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937821026818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0002937821026818"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2021.12.021","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is there a relationship between plasma, cytokine concentrations, and the subsequent risk of postpartum hemorrhage?","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2021.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}