{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:51:22Z","timestamp":1793267482552,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000764","name":"King&apos;s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ajog.2022.04.002","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T11:58:23Z","timestamp":1649246303000},"page":"72.e1-72.e16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Predictive RNA profiles for early and very early spontaneous preterm birth"],"prefix":"10.1016","volume":"227","author":[{"given":"Joan","family":"Camunas-Soler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine P.S.","family":"Gee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsu","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Dai","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mainou","family":"Thao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Brundage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farooq","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha L.","family":"Hezelgrave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Shennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeni","family":"Namsaraev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Haverty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneesh","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal A.","family":"Elovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-5683","authenticated-orcid":false,"given":"Morten","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Tribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2022.04.002_bib1","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","article-title":"Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis","volume":"7","author":"Chawanpaiboon","year":"2019","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.ajog.2022.04.002_bib2","doi-asserted-by":"crossref","first-page":"e1179","DOI":"10.1016\/S2214-109X(21)00337-5","article-title":"The rising preterm birth rate in China: a cause for concern","volume":"9","author":"Zhang","year":"2021","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.ajog.2022.04.002_bib3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1056\/NEJMoa0706475","article-title":"Long-term medical and social consequences of preterm birth","volume":"359","author":"Moster","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2022.04.002_bib4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1055\/s-0035-1571202","article-title":"Short- and long-term outcomes for extremely preterm infants","volume":"33","author":"Patel","year":"2016","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajog.2022.04.002_bib5","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1001\/jama.2019.15040","article-title":"Prevalence of survival without major comorbidities among adults born prematurely","volume":"322","author":"Crump","year":"2019","journal-title":"JAMA"},{"issue":"Suppl3","key":"10.1016\/j.ajog.2022.04.002_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1471-0528.2006.01120.x","article-title":"The preterm parturition syndrome","volume":"113","author":"Romero","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2022.04.002_bib7","doi-asserted-by":"crossref","first-page":"581.e1","DOI":"10.1016\/j.ajog.2007.09.016","article-title":"Second-trimester loss and subsequent pregnancy outcomes: what is the real risk?","volume":"197","author":"Edlow","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.04.002_bib8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ajog.2022.04.002_bib9","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1001\/jama.2017.1373","article-title":"Predictive accuracy of serial transvaginal cervical lengths and quantitative vaginal fetal fibronectin levels for spontaneous preterm birth among nulliparous women","volume":"317","author":"Esplin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2022.04.002_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/uog.20422","article-title":"Development and validation of predictive models for QUiPP App v.2: tool for predicting preterm birth in women with symptoms of threatened preterm labor","volume":"55","author":"Carter","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.04.002_bib11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/uog.20401","article-title":"Development and validation of predictive models for QUiPP App v.2: tool for predicting preterm birth in asymptomatic high-risk women","volume":"55","author":"Watson","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.04.002_bib12","doi-asserted-by":"crossref","first-page":"100140","DOI":"10.1016\/j.ajogmf.2020.100140","article-title":"Performance of a proteomic preterm delivery predictor in a large independent prospective cohort","volume":"2","author":"Markenson","year":"2020","journal-title":"Am J Obstet Gynecol MFM"},{"key":"10.1016\/j.ajog.2022.04.002_bib13","doi-asserted-by":"crossref","first-page":"633.e1","DOI":"10.1016\/j.ajog.2016.02.001","article-title":"Development and validation of a spontaneous preterm delivery predictor in asymptomatic women","volume":"214","author":"Saade","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.04.002_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11306-016-0985-x","article-title":"Identifying metabolite markers for preterm birth in cervicovaginal fluid by magnetic resonance spectroscopy","volume":"12","author":"Amabebe","year":"2016","journal-title":"Metabolomics"},{"key":"10.1016\/j.ajog.2022.04.002_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149257","article-title":"Cervicovaginal microbiota and metabolome predict preterm birth risk in an ethnically diverse cohort","volume":"6","author":"Flaviani","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.ajog.2022.04.002_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155191","article-title":"Maternal whole blood gene expression at 18 and 28 weeks of gestation associated with spontaneous preterm birth in asymptomatic women","volume":"11","author":"Heng","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2022.04.002_bib17","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.3389\/fimmu.2019.02863","article-title":"The cellular transcriptome in the maternal circulation during normal pregnancy: a longitudinal study","volume":"10","author":"Gomez-Lopez","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajog.2022.04.002_bib18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s43032-019-00027-2","article-title":"EBF1 gene mRNA levels in maternal blood and spontaneous preterm birth","volume":"27","author":"Zhou","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajog.2022.04.002_bib19","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/1471-0528.16736","article-title":"Early pregnancy prediction of spontaneous preterm birth before 32 completed weeks of pregnancy using plasma RNA: transcriptome discovery and initial validation of an RNA panel of markers","volume":"128","author":"Weiner","year":"2021","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2022.04.002_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.siny.2017.11.007","article-title":"Screening for spontaneous preterm birth and resultant therapies to reduce neonatal morbidity and mortality: a review","volume":"23","author":"Glover","year":"2018","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2022.04.002_bib21","doi-asserted-by":"crossref","first-page":"eaaz0131","DOI":"10.1126\/scitranslmed.aaz0131","article-title":"Circulating transcripts in maternal blood reflect a molecular signature of early-onset preeclampsia","volume":"12","author":"Munchel","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajog.2022.04.002_bib22","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1126\/science.aar3819","article-title":"Noninvasive blood tests for fetal development predict gestational age and preterm delivery","volume":"360","author":"Ngo","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.ajog.2022.04.002_bib23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41586-021-04249-w","article-title":"RNA profiles reveal signatures of future health and disease in pregnancy","volume":"601","author":"Rasmussen","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2022.04.002_bib24","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajog.2022.04.002_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajog.2022.04.002_bib26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajog.2022.04.002_bib27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41592-020-0772-5","article-title":"Author Correction: SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajog.2022.04.002_bib28","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajog.2022.04.002_bib29","doi-asserted-by":"crossref","first-page":"W186","DOI":"10.1093\/nar\/gkm323","article-title":"GeneTrail--advanced gene set enrichment analysis","volume":"35","author":"Backes","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajog.2022.04.002_bib30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1477-7827-9-107","article-title":"Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction","volume":"9","author":"Nishizawa","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ajog.2022.04.002_bib31","doi-asserted-by":"crossref","first-page":"122.e1","DOI":"10.1016\/j.ajog.2012.10.890","article-title":"Evaluation of a quantitative fetal fibronectin test for spontaneous preterm birth in symptomatic women","volume":"208","author":"Abbott","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.04.002_bib32","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJM199602293340904","article-title":"The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network","volume":"334","author":"Iams","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2022.04.002_bib33","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1055\/s-0038-1677472","article-title":"Early postnatal IGF-1 and IGFBP-1 blood levels in extremely preterm infants: relationships with indicators of placental insufficiency and with systemic inflammation","volume":"36","author":"Leviton","year":"2019","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajog.2022.04.002_bib34","doi-asserted-by":"crossref","first-page":"100323","DOI":"10.1016\/j.xcrm.2021.100323","article-title":"Crowdsourcing assessment of maternal blood\u00a0multi-omics for predicting gestational age and preterm birth","volume":"2","author":"Tarca","year":"2021","journal-title":"Cell Rep Med"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937822002678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937822002678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:38:08Z","timestamp":1757590688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937822002678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0002937822002678"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2022.04.002","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictive RNA profiles for early and very early spontaneous preterm birth","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2022.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}