{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:26:12Z","timestamp":1785839172140,"version":"3.56.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR1955\/4-1"],"award-info":[{"award-number":["GR1955\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ajog.2022.07.028","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T15:20:10Z","timestamp":1659453610000},"page":"84.e1-84.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of pentaerythritol tetranitrate (PETN) on the development of fetal growth restriction in pregnancies with impaired uteroplacental perfusion at midgestation\u2014a randomized trial"],"prefix":"10.1016","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-4056","authenticated-orcid":false,"given":"Tanja","family":"Groten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-7923","authenticated-orcid":false,"given":"Thomas","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariann","family":"St\u00e4dtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Komar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Lucia","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7456-9625","authenticated-orcid":false,"given":"Mateja","family":"Condic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Strizek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Seeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-1262","authenticated-orcid":false,"given":"Ulrich","family":"Pecks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Eckmann-Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Oliver","family":"Kagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hoopmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin S.","family":"von Kaisenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Brodowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tauscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Schrey-Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-9741","authenticated-orcid":false,"given":"Ulrike","family":"Friebe-Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztian","family":"Lato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"H\u00fcbener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0724-5241","authenticated-orcid":false,"given":"Maria","family":"Delius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Verlohren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-7616","authenticated-orcid":false,"given":"Dorota","family":"Sroka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Schlembach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-9303","authenticated-orcid":false,"given":"Gregor","family":"Seliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Schleu\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2022.07.028_bib1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.bpobgyn.2009.09.001","article-title":"Intrauterine growth restriction: new standards for assessing adverse outcome","volume":"23","author":"Gardosi","year":"2009","journal-title":"Best\u00a0Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2022.07.028_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2022.07.028_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1053\/j.semperi.2014.03.004","article-title":"Epidemiology of ischemic placental disease: a focus on preterm gestations","volume":"38","author":"Parker","year":"2014","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajog.2022.07.028_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/uog.15884","article-title":"Consensus definition of fetal growth restriction: a Delphi procedure","volume":"48","author":"Gordijn","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.07.028_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00392-007-0588-7","article-title":"New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance","volume":"97","author":"Daiber","year":"2008","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.ajog.2022.07.028_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1515\/jpm-2013-0212","article-title":"Impact of the nitric oxide-donor pentaerythrityl-tetranitrate on perinatal outcome in risk pregnancies: a prospective, randomized, double-blinded trial","volume":"42","author":"Schleussner","year":"2014","journal-title":"J\u00a0Perinat Med"},{"key":"10.1016\/j.ajog.2022.07.028_bib7","doi-asserted-by":"crossref","first-page":"E80","DOI":"10.1016\/j.placenta.2019.06.254","article-title":"Pentaerithrityl tetranitrate (PETN) for secondary prevention of intrauterine growth restriction (PETN)","volume":"83","author":"Groten","year":"2019","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2022.07.028_bib8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/uog.5315","article-title":"Reference ranges for uterine artery mean pulsatility index at 11-41 weeks of gestation","volume":"32","author":"G\u00f3mez","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.07.028_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1515\/jpm.2010.031","article-title":"Birth weight percentile charts based on daily measurements for very preterm male and female infants at the age of 154-223 days","volume":"38","author":"Voigt","year":"2010","journal-title":"J\u00a0Perinat Med"},{"key":"10.1016\/j.ajog.2022.07.028_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.preghy.2021.09.008","article-title":"The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice","volume":"27","author":"Magee","year":"2022","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ajog.2022.07.028_bib11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1503\/cmaj.070430","article-title":"Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis","volume":"178","author":"Cnossen","year":"2008","journal-title":"CMAJ"},{"key":"10.1016\/j.ajog.2022.07.028_bib12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/uog.14826","article-title":"Prediction of small-for-gestational-age neonates: screening by fetal biometry at 19-24 weeks","volume":"46","author":"Lesmes","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.07.028_bib13","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1515\/jpm-2017-0238","article-title":"Pentaerythrityltetranitrate (PETN) improves utero- and feto-placental Doppler parameters in pregnancies with impaired utero-placental perfusion in mid-gestation - a secondary analysis of the PETN-pilot trial","volume":"46","author":"Bowkalow","year":"2018","journal-title":"J\u00a0Perinat Med"},{"key":"10.1016\/j.ajog.2022.07.028_bib14","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1097\/HJH.0000000000000612","article-title":"Effect of birth weight on life-course blood pressure levels among children born premature: the cardiovascular Risk in Young Finns Study","volume":"33","author":"Juonala","year":"2015","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.ajog.2022.07.028_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrendo.2016.127","article-title":"Long-term metabolic risk among children born premature or small for gestational age","volume":"13","author":"Mericq","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ajog.2022.07.028_bib16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/jp.2011.201","article-title":"NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction","volume":"32","author":"Als","year":"2012","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.ajog.2022.07.028_bib17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/jp.2010.81","article-title":"Is the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) effective for preterm infants with intrauterine growth restriction?","volume":"31","author":"Als","year":"2011","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.ajog.2022.07.028_bib18","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/HYPERTENSIONAHA.117.09690","article-title":"Sildenafil during pregnancy: a preclinical meta-analysis on fetal growth and maternal blood pressure","volume":"70","author":"Paauw","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2022.07.028_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/AOG.0000000000001518","article-title":"Perinatal and hemodynamic evaluation of sildenafil citrate for preeclampsia treatment: a randomized controlled trial","volume":"128","author":"Trapani","year":"2016","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2022.07.028_bib20","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13063-018-3136-z","volume":"20","author":"Pels","year":"2019","journal-title":"Trials"},{"key":"10.1016\/j.ajog.2022.07.028_bib21","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/1471-0528.15658","article-title":"Strider NZAus: a multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction","volume":"126","author":"Groom","year":"2019","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2022.07.028_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S2352-4642(17)30173-6","article-title":"Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial","volume":"2","author":"Sharp","year":"2018","journal-title":"Lancet Child Adolesc Health"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293782200583X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000293782200583X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T14:56:25Z","timestamp":1751381785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000293782200583X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S000293782200583X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2022.07.028","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of pentaerythritol tetranitrate (PETN) on the development of fetal growth restriction in pregnancies with impaired uteroplacental perfusion at midgestation\u2014a randomized trial","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2022.07.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}