{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:02:51Z","timestamp":1782133371198,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"am","delay-in-days":354,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001422"],"award-info":[{"award-number":["UL1TR001422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001439"],"award-info":[{"award-number":["UL1TR001439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U10HD047892"],"award-info":[{"award-number":["U10HD047892"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U24HD36801"],"award-info":[{"award-number":["U24HD36801"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U54HD047891"],"award-info":[{"award-number":["U54HD047891"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U54HD047905"],"award-info":[{"award-number":["U54HD047905"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U54HD085601"],"award-info":[{"award-number":["U54HD085601"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["UG1HD40485"],"award-info":[{"award-number":["UG1HD40485"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["UG1HD40512"],"award-info":[{"award-number":["UG1HD40512"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["UG1HD53097"],"award-info":[{"award-number":["UG1HD53097"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["UG1HD87230"],"award-info":[{"award-number":["UG1HD87230"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.ajog.2023.02.016","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T18:57:11Z","timestamp":1677265031000},"page":"153.e1-153.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-term neurodevelopmental follow-up of children exposed to pravastatin in utero"],"prefix":"10.1016","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4076-469X","authenticated-orcid":false,"given":"Maged M.","family":"Costantine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca G.","family":"Clifton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha M.","family":"Boekhoudt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Gyamfi-Bannerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Wisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Grobman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve N.","family":"Caritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyagriv N.","family":"Simhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Saade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2023.02.016_bib1","first-page":"1","article-title":"ACOG Practice Bulletin No. 202: gestational hypertension and preeclampsia","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bpobgyn.2011.04.002","article-title":"Pre-eclampsia in low and middle income countries","volume":"25","author":"Firoz","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.32779","article-title":"Mortality among young adults born preterm and early term in 4 Nordic nations","volume":"4","author":"Risnes","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ajog.2023.02.016_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-028982","article-title":"Impact of gestational age on child intelligence, attention and executive function at age 5: a cohort study","volume":"9","author":"Sejer","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.ajog.2023.02.016_bib5","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/jamapsychiatry.2018.0854","article-title":"Association of hypertensive disorders of pregnancy with risk of neurodevelopmental disorders in offspring: a systematic review and meta-analysis","volume":"75","author":"Maher","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajog.2023.02.016_bib6","doi-asserted-by":"crossref","first-page":"200.e1","DOI":"10.1016\/j.ajog.2012.12.017","article-title":"Maternal hypertensive disorders in pregnancy and self-reported cognitive impairment of the offspring 70 years later: the Helsinki Birth Cohort Study","volume":"208","author":"Tuovinen","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib7","doi-asserted-by":"crossref","first-page":"510.e1","DOI":"10.1016\/j.ajog.2011.02.032","article-title":"Outcome at 4.5 years of children born after expectant management of early-onset hypertensive disorders of pregnancy","volume":"204","author":"van Wassenaer","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1001\/jamapsychiatry.2020.0306","article-title":"Association of preeclampsia in term births with neurodevelopmental disorders in offspring","volume":"77","author":"Sun","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajog.2023.02.016_bib9","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1055\/s-0040-1713651","article-title":"Evaluating the effect of pravastatin in early-onset fetal growth restriction: a nonrandomized and historically controlled pilot study","volume":"38","author":"Mendoza","year":"2021","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajog.2023.02.016_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1542\/peds.2008-2816","article-title":"Meta-analysis of neurobehavioral outcomes in very preterm and\/or very low birth weight children","volume":"124","author":"Aarnoudse-Moens","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2023.02.016_bib11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/jamapediatrics.2014.2645","article-title":"Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay","volume":"169","author":"Walker","year":"2015","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.ajog.2023.02.016_bib12","doi-asserted-by":"crossref","first-page":"S1171","DOI":"10.1016\/j.ajog.2020.08.040","article-title":"The role of statins in the prevention of preeclampsia","volume":"226","author":"Smith","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nri1839","article-title":"Statin therapy and autoimmune disease: from protein prenylation to immunomodulation","volume":"6","author":"Greenwood","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajog.2023.02.016_bib14","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajog.2023.02.016_bib15","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1042\/BST0371237","article-title":"Can the biology of VEGF and haem oxygenases help solve pre-eclampsia?","volume":"37","author":"Ahmed","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.ajog.2023.02.016_bib16","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.freeradbiomed.2004.09.009","article-title":"The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells","volume":"37","author":"Grosser","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajog.2023.02.016_bib17","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.CIR.97.12.1129","article-title":"Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors","volume":"97","author":"Laufs","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ajog.2023.02.016_bib18","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1073\/pnas.95.15.8880","article-title":"Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase","volume":"95","author":"Endres","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2023.02.016_bib19","doi-asserted-by":"crossref","first-page":"S1157","DOI":"10.1016\/j.ajog.2020.09.014","article-title":"Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia","volume":"226","author":"Tong","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib20","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1172\/JCI86957","article-title":"Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy","volume":"126","author":"Lefkou","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2023.02.016_bib21","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1182\/blood-2008-12-194258","article-title":"Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury","volume":"113","author":"Redecha","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ajog.2023.02.016_bib22","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1073\/pnas.1011293108","article-title":"Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model","volume":"108","author":"Kumasawa","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2023.02.016_bib23","doi-asserted-by":"crossref","first-page":"8055","DOI":"10.1080\/14767058.2021.1940940","article-title":"Pravastatin is useful for prevention of recurrent severe placenta-mediated complications - a pilot study","volume":"35","author":"Kupferminc","year":"2022","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2023.02.016_bib25","doi-asserted-by":"crossref","first-page":"373.e1","DOI":"10.1016\/j.ajog.2013.05.038","article-title":"Transplacental transfer and distribution of pravastatin","volume":"209","author":"Nanovskaya","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib26","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.placenta.2013.05.002","article-title":"The transfer of pravastatin in the dually perfused human placenta","volume":"34","author":"Zarek","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2023.02.016_bib27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2165\/00003088-200039060-00002","article-title":"Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events","volume":"39","author":"Hatanaka","year":"2000","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.ajog.2023.02.016_bib28","doi-asserted-by":"crossref","first-page":"666.e1","DOI":"10.1016\/j.ajog.2021.05.018","article-title":"A\u00a0randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia","volume":"225","author":"Costantine","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib29","doi-asserted-by":"crossref","first-page":"720.e1","DOI":"10.1016\/j.ajog.2015.12.038","article-title":"Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: a pilot randomized controlled trial","volume":"214","author":"Costantine","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/AOG.0b013e31827d8ad5","article-title":"Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric--Fetal Pharmacology Research Units Network\u2217. Pravastatin for the prevention of preeclampsia in high-risk pregnant women","volume":"121","author":"Costantine","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ajmg.a.30386","article-title":"Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins","volume":"131","author":"Edison","year":"2004","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajog.2023.02.016_bib32","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1365-2125.2007.02905.x","article-title":"Risk of congenital anomalies in pregnant users of statin drugs","volume":"64","author":"Ofori","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ajog.2023.02.016_bib33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.reprotox.2008.06.009","article-title":"Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomes","volume":"26","author":"Taguchi","year":"2008","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.ajog.2023.02.016_bib34","doi-asserted-by":"crossref","first-page":"h1035","DOI":"10.1136\/bmj.h1035","article-title":"Statins and congenital malformations: cohort study","volume":"350","author":"Bateman","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2023.02.016_bib35","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1002\/ajmg.a.32493","article-title":"Maternal exposure to statins and risk for birth defects: a case-series approach","volume":"146A","author":"Petersen","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajog.2023.02.016_bib36","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/1471-0528.12066","article-title":"Pregnancy outcome following maternal exposure to statins: a multicentre prospective study","volume":"120","author":"Winterfeld","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2023.02.016_bib37","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jacl.2016.07.002","article-title":"The risks of statin use in pregnancy: a systematic review","volume":"10","author":"Karalis","year":"2016","journal-title":"J\u00a0Clin Lipidol"},{"key":"10.1016\/j.ajog.2023.02.016_bib38","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCULATIONAHA.121.053963","article-title":"Pravastatin versus placebo in pregnancies at high risk of term preeclampsia","volume":"144","author":"D\u00f6bert","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.ajog.2023.02.016_bib39","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/1471-0528.16013","article-title":"Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial","volume":"127","author":"Ahmed","year":"2020","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2023.02.016_bib40","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.earlhumdev.2014.07.014","article-title":"Auditory neural myelination is associated with early childhood language development in premature infants","volume":"90","author":"Amin","year":"2014","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ajog.2023.02.016_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijdevneu.2013.11.004","article-title":"The effect of maternal pravastatin therapy on adverse sensorimotor outcomes of the offspring in a murine model of preeclampsia","volume":"33","author":"Carver","year":"2014","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.ajog.2023.02.016_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100873","article-title":"Maternal pravastatin prevents altered fetal brain development in a preeclamptic CD-1 mouse model","volume":"9","author":"Carver","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajog.2023.02.016_bib43","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120147","article-title":"Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice","volume":"3","author":"Garrett","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.ajog.2023.02.016_bib44","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/01.STR.0000080677.24419.88","volume":"34","author":"Balduini","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.ajog.2023.02.016_bib45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/1874467209666160112123457","article-title":"Statins, mevalonate pathway and its intermediate products in placental development and preeclampsia","volume":"10","author":"Ermini","year":"2017","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.ajog.2023.02.016_bib46","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/HYPERTENSIONAHA.111.175919","article-title":"Role of complement component C1q in the onset of preeclampsia in mice","volume":"58","author":"Singh","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.ajog.2023.02.016_bib47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jri.2017.09.009","article-title":"Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies","volume":"124","author":"Girardi","year":"2017","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ajog.2023.02.016_bib48","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1161\/CIRCULATIONAHA.106.660134","article-title":"Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1","volume":"115","author":"Cudmore","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ajog.2023.02.016_bib49","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/AOG.0b013e3181e10ebd","article-title":"Using pravastatin to improve the vascular reactivity in a mouse model of soluble fms-like tyrosine kinase-1-induced preeclampsia","volume":"116","author":"Costantine","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/14767058.2015.1129779","article-title":"Pravastatin for the prevention of adverse pregnancy outcome: preeclampsia and more?","volume":"30","author":"Chaiworapongsa","year":"2017","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2023.02.016_bib51","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3109\/14767058.2015.1022864","article-title":"Pravastatin to prevent recurrent fetal death in massive perivillous fibrin deposition of the placenta (MPFD)","volume":"29","author":"Chaiworapongsa","year":"2016","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2023.02.016_bib52","doi-asserted-by":"crossref","first-page":"366.e1","DOI":"10.1016\/j.ajog.2011.06.083","article-title":"Effects of pravastatin on mediators of vascular function in a mouse model of soluble Fms-like tyrosine kinase-1-induced preeclampsia","volume":"205","author":"Fox","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.02.016_bib53","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/1933719113492207","article-title":"Effects of pravastatin on angiogenic and placental hypoxic imbalance in a mouse model of preeclampsia","volume":"21","author":"Saad","year":"2014","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajog.2023.02.016_bib54","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/HYPERTENSIONAHA.111.00226","article-title":"Pravastatin attenuates hypertension, oxidative stress, and angiogenic imbalance in rat model of placental ischemia-induced hypertension","volume":"61","author":"Bauer","year":"2013","journal-title":"Hypertension"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937823001114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937823001114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:42:55Z","timestamp":1757590975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937823001114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0002937823001114"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2023.02.016","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term neurodevelopmental follow-up of children exposed to pravastatin in utero","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2023.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}