{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:24:20Z","timestamp":1780939460060,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"am","delay-in-days":358,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD099843"],"award-info":[{"award-number":["R01HD099843"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD102206"],"award-info":[{"award-number":["R01HD102206"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD108705"],"award-info":[{"award-number":["R01HD108705"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01HD100195"],"award-info":[{"award-number":["R01HD100195"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.ajog.2023.07.048","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:59:45Z","timestamp":1690801185000},"page":"254.e1-254.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["MicroRNA-322 overexpression reduces neural tube defects in diabetic pregnancies"],"prefix":"10.1016","volume":"230","author":[{"given":"Guanglei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Bin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Albert","family":"Reece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-0699","authenticated-orcid":false,"given":"Peixin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2023.07.048_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajmg.c.30056","article-title":"Current perspectives on the causes of neural tube defects resulting from diabetic pregnancy","volume":"135C","author":"Loeken","year":"2005","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.ajog.2023.07.048_bib2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1146\/annurev-genet-120213-092208","article-title":"Genetic, epigenetic, and environmental contributions to neural tube closure","volume":"48","author":"Wilde","year":"2014","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.ajog.2023.07.048_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2337\/db12-0026","article-title":"C-Jun NH2-terminal kinase 1\/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy","volume":"62","author":"Li","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.ajog.2023.07.048_bib4","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.2337\/db11-1624","article-title":"Oxidative stress-induced JNK1\/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy","volume":"61","author":"Li","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.ajog.2023.07.048_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ajog.2015.01.016","article-title":"Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy","volume":"213","author":"Wang","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ajog.2014.11.036","article-title":"Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling","volume":"212","author":"Yang","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ajog.2015.09.082","article-title":"New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects","volume":"214","author":"Dong","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib8","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/S0140-6736(02)08599-9","article-title":"Type 2 diabetes in pregnancy: a growing concern","volume":"359","author":"Feig","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2023.07.048_bib9","doi-asserted-by":"crossref","first-page":"237.e1","DOI":"10.1016\/j.ajog.2008.06.028","article-title":"Diabetes mellitus and birth defects","volume":"199","author":"Correa","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib10","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1001\/jama.285.23.2981","article-title":"Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects","volume":"285","author":"Honein","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2023.07.048_bib11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1542\/pir.21.2.58","article-title":"Prevention of neural tube defects by periconceptional use of folic acid","volume":"21","author":"Iqbal","year":"2000","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.ajog.2023.07.048_bib12","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1136\/bmj.329.7479.1375","article-title":"Taking folate in pregnancy and risk of maternal breast cancer","volume":"329","author":"Charles","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2023.07.048_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1398-9995.2011.02714.x","article-title":"The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood","volume":"67","author":"Dunstan","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.ajog.2023.07.048_bib14","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/bdra.20819","article-title":"MicroRNA gene expression signatures in the developing neural tube","volume":"91","author":"Mukhopadhyay","year":"2011","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ajog.2023.07.048_bib15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1471-4159.2012.07812.x","article-title":"Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects","volume":"122","author":"Gu","year":"2012","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.ajog.2023.07.048_bib16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.biocel.2009.11.023","article-title":"MicroRNAs: potential regulators involved in human anencephaly","volume":"42","author":"Zhang","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ajog.2023.07.048_bib17","doi-asserted-by":"crossref","first-page":"9551","DOI":"10.1073\/pnas.1608256113","article-title":"miR-322\/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification","volume":"113","author":"Shen","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2023.07.048_bib18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/toxsci\/kfu271","article-title":"The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells","volume":"144","author":"Gu","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.ajog.2023.07.048_bib19","doi-asserted-by":"crossref","first-page":"197.e1","DOI":"10.1016\/j.ajog.2018.04.045","article-title":"Modulation of nuclear factor-\u03baB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice","volume":"219","author":"Tan","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib20","doi-asserted-by":"crossref","first-page":"345.e1","DOI":"10.1016\/j.ajog.2013.06.037","article-title":"Superoxide dismutase 1 overexpression in mice abolishes maternal diabetes-induced endoplasmic reticulum stress in diabetic embryopathy","volume":"209","author":"Wang","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1226191","article-title":"IRE1\u03b1 cleaves select microRNAs during ER stress to derepress translation of proapoptotic caspase-2","volume":"338","author":"Upton","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ajog.2023.07.048_bib22","article-title":"Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy","volume":"8","author":"Wang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajog.2023.07.048_bib23","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nature01124","article-title":"Progenitor cell maintenance requires numb and numblike during mouse neurogenesis","volume":"419","author":"Petersen","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2023.07.048_bib24","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/1471-2164-14-568","article-title":"Global expression profiling reveals genetic programs underlying the developmental divergence between mouse and human embryogenesis","volume":"14","author":"Xue","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ajog.2023.07.048_bib25","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/CIRCULATIONAHA.115.017465","article-title":"Prepregnancy diabetes and offspring risk of congenital heart disease: a nationwide cohort study","volume":"133","author":"\u00d8yen","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ajog.2023.07.048_bib26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cmet.2006.07.007","article-title":"Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1","volume":"4","author":"Lipson","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajog.2023.07.048_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf5089","article-title":"Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin","volume":"7","author":"Xu","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.ajog.2023.07.048_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ajog.2023.07.048_bib29","doi-asserted-by":"crossref","first-page":"802.e1","DOI":"10.1016\/j.ajog.2015.01.017","article-title":"Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis","volume":"212","author":"Wu","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/CIRCRESAHA.121.320530","article-title":"Unfolded protein response differentially modulates the platelet phenotype","volume":"131","author":"Jain","year":"2022","journal-title":"Circ Res"},{"key":"10.1016\/j.ajog.2023.07.048_bib31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1\u03b1 induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajog.2023.07.048_bib32","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cell.2009.07.017","article-title":"IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates","volume":"138","author":"Han","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ajog.2023.07.048_bib33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jnutbio.2005.06.007","article-title":"Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications","volume":"16","author":"Allen","year":"2005","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.ajog.2023.07.048_bib34","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1101\/gad.992302","article-title":"ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats","volume":"16","author":"Nishitoh","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajog.2023.07.048_bib35","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1123480","article-title":"Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha","volume":"312","author":"Hetz","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ajog.2023.07.048_bib36","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41467-018-08268-6","article-title":"Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy","volume":"10","author":"Yang","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajog.2023.07.048_bib37","doi-asserted-by":"crossref","first-page":"16657","DOI":"10.1073\/pnas.0903775106","article-title":"Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability","volume":"106","author":"Iwawaki","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2023.07.048_bib38","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1091\/mbc.e10-01-0062","article-title":"MiR-322\/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A","volume":"21","author":"Sarkar","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajog.2023.07.048_bib39","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1172\/JCI42980","article-title":"Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-\u03b1 isoforms and promotes angiogenesis","volume":"120","author":"Ghosh","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ajog.2023.07.048_bib40","doi-asserted-by":"crossref","first-page":"14264","DOI":"10.1074\/jbc.M112.432104","article-title":"MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability","volume":"288","author":"G\u00e1mez","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ajog.2023.07.048_bib41","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1101\/gad.237404.114","article-title":"The miR-424(322)\/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland","volume":"28","author":"Llobet-Navas","year":"2014","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajog.2023.07.048_bib42","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tibs.2012.07.002","article-title":"MicroRNA turnover: when, how, and why","volume":"37","author":"R\u00fcegger","year":"2012","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.ajog.2023.07.048_bib43","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ajog.2023.07.048_bib44","doi-asserted-by":"crossref","first-page":"ra54","DOI":"10.1126\/scisignal.2004983","article-title":"Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis","volume":"7","author":"Groenendyk","year":"2014","journal-title":"Sci Signal"},{"key":"10.1016\/j.ajog.2023.07.048_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/srep18304","article-title":"PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response","volume":"5","author":"Gupta","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajog.2023.07.048_bib46","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1073\/pnas.94.6.2460","article-title":"Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB","volume":"94","author":"VanArsdale","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2023.07.048_bib47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41419-020-03278-z","article-title":"TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-\u03baB pathways","volume":"12","author":"Zhou","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajog.2023.07.048_bib48","first-page":"7","article-title":"TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function","volume":"27","author":"Kotsaris","year":"2020","journal-title":"J\u00a0Biol Res (Thessalon)"},{"key":"10.1016\/j.ajog.2023.07.048_bib49","doi-asserted-by":"crossref","first-page":"753.e1","DOI":"10.1016\/j.ajog.2020.05.015","article-title":"Deficiency of the oxidative stress-responsive kinase p70S6K1 restores autophagy and ameliorates neural tube defects in diabetic embryopathy","volume":"223","author":"Cao","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib50","doi-asserted-by":"crossref","first-page":"650.e1","DOI":"10.1016\/j.ajog.2015.01.014","article-title":"Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart","volume":"212","author":"Wang","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib51","doi-asserted-by":"crossref","first-page":"E487","DOI":"10.1152\/ajpendo.00121.2015","article-title":"ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development","volume":"309","author":"Wang","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajog.2023.07.048_bib52","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ajog.2022.04.024","article-title":"Telomeres, oxidative stress, and timing for spontaneous term and preterm labor","volume":"227","author":"Phillippe","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib53","doi-asserted-by":"crossref","first-page":"596.e1","DOI":"10.1016\/j.ajog.2019.02.028","article-title":"Immune tolerance attenuates gut dysbiosis, dysregulated uterine gene expression and high-fat diet potentiated preterm birth in mice","volume":"220","author":"Manuel","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib54","doi-asserted-by":"crossref","first-page":"681.e1","DOI":"10.1016\/j.ajog.2021.06.075","article-title":"Placental extracellular vesicles-associated microRNA-519c mediates endotoxin adaptation in pregnancy","volume":"225","author":"Tiozzo","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib55","doi-asserted-by":"crossref","first-page":"480.e1","DOI":"10.1016\/j.ajog.2019.01.228","article-title":"Deregulation of miR-324\/KISS1\/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications","volume":"220","author":"Romero-Ruiz","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib56","doi-asserted-by":"crossref","first-page":"497.e1","DOI":"10.1016\/j.ajog.2019.11.1286","article-title":"Early-onset preeclampsia, plasma microRNAs, and endothelial cell function","volume":"222","author":"Lip","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib57","doi-asserted-by":"crossref","first-page":"46.e1","DOI":"10.1016\/j.ajog.2019.02.047","article-title":"MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth","volume":"221","author":"Balaguer","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib58","doi-asserted-by":"crossref","first-page":"478.e1","DOI":"10.1016\/j.ajog.2018.08.021","article-title":"Amnion epithelial cell-derived exosomes induce inflammatory changes in uterine cells","volume":"219","author":"Hadley","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib59","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1095\/biolreprod.114.120741","article-title":"Endoplasmic reticulum stress is increased after spontaneous labor in human fetal membranes and myometrium where it regulates the expression of prolabor mediators","volume":"91","author":"Liong","year":"2014","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2023.07.048_bib60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/jhh.2016.17","article-title":"eNOS\/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia","volume":"31","author":"Du","year":"2017","journal-title":"J\u00a0Hum Hypertens"},{"key":"10.1016\/j.ajog.2023.07.048_bib61","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/path.4394","article-title":"Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early- and late-onset pre-eclampsia","volume":"234","author":"Yung","year":"2014","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.ajog.2023.07.048_bib62","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.3390\/cancers14102526","article-title":"IRE1\u03b1 inhibitors as a promising therapeutic strategy in blood malignancies","volume":"14","author":"Wiese","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ajog.2023.07.048_bib63","doi-asserted-by":"crossref","first-page":"E1395","DOI":"10.1073\/pnas.1621188114","article-title":"Targeting IRE1 with small molecules counteracts progression of atherosclerosis","volume":"114","author":"Tufanli","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2023.07.048_bib64","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2174\/2211536611666211228100811","article-title":"The regulatory network played by miRNAs during normal pregnancy and preeclampsia: a comparative study","volume":"10","author":"Ojeda-Casares","year":"2021","journal-title":"MicroRNA"},{"key":"10.1016\/j.ajog.2023.07.048_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.832577","article-title":"Serum exosomes microRNAs are novel non-invasive biomarkers of intrahepatic cholestasis of pregnancy","volume":"13","author":"Dong","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.ajog.2023.07.048_bib66","article-title":"Epigenetics in congenital heart disease","volume":"11","author":"Wang","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.ajog.2023.07.048_bib67","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fgene.2019.00478","article-title":"The potential for microRNA therapeutics and clinical research","volume":"10","author":"Hanna","year":"2019","journal-title":"Front Genet"},{"key":"10.1016\/j.ajog.2023.07.048_bib68","doi-asserted-by":"crossref","first-page":"S1171","DOI":"10.1016\/j.ajog.2020.08.040","article-title":"The role of statins in the prevention of preeclampsia","volume":"226","author":"Smith","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib69","doi-asserted-by":"crossref","first-page":"S928","DOI":"10.1016\/j.ajog.2020.11.005","article-title":"Placental energy metabolism in health and disease-significance of development and implications for preeclampsia","volume":"226","author":"Aye","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib70","doi-asserted-by":"crossref","first-page":"S945","DOI":"10.1016\/j.ajog.2021.11.1367","article-title":"Pregnancy-specific expression of protease-activated receptor 1: a therapeutic target for prevention and treatment of preeclampsia?","volume":"226","author":"Walsh","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.07.048_bib71","doi-asserted-by":"crossref","first-page":"576.e1","DOI":"10.1016\/j.ajog.2022.11.1282","article-title":"Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study","volume":"228","author":"Eick","year":"2023","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937823005203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937823005203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:44:51Z","timestamp":1757591091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937823005203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0002937823005203"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2023.07.048","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-322 overexpression reduces neural tube defects in diabetic pregnancies","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2023.07.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}