{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:23:33Z","timestamp":1791998613295,"version":"4.4.0"},"reference-count":87,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD060530"],"award-info":[{"award-number":["HD060530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.ajog.2023.12.040","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T04:15:54Z","timestamp":1704514554000},"page":"438.e1-438.e15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis"],"prefix":"10.1016","volume":"230","author":[{"given":"Changfeng","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Scott","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Rasooly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia Casson","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2023.12.040_bib1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: a systematic review","volume":"124","author":"Stewart","year":"2017","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2023.12.040_bib2","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1093\/humrep\/deh407","article-title":"Uterine leiomyoma and menstrual cycle characteristics in a population-based cohort study","volume":"19","author":"Marino","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajog.2023.12.040_bib3","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0015-0282(98)00208-8","article-title":"A\u00a0prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata","volume":"70","author":"Marshall","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2023.12.040_bib4","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1016\/j.fertnstert.2010.04.065","article-title":"Reproductive characteristics and risk of uterine leiomyomata","volume":"94","author":"Terry","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2023.12.040_bib5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/aje\/kwh016","article-title":"Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: a prospective study","volume":"159","author":"Wise","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1210\/er.2009-0006","article-title":"Ovarian aging: mechanisms and clinical consequences","volume":"30","author":"Broekmans","year":"2009","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ajog.2023.12.040_bib7","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ng.3841","article-title":"Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk","volume":"49","author":"Day","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41586-021-03779-7","article-title":"Genetic insights into biological mechanisms governing human ovarian ageing","volume":"596","author":"Ruth","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2023.12.040_bib9","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/s41562-021-01135-3","article-title":"Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour","volume":"5","author":"Mills","year":"2021","journal-title":"Nat Hum Behav"},{"key":"10.1016\/j.ajog.2023.12.040_bib10","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1038\/s41467-019-12536-4","article-title":"Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis","volume":"10","author":"Gallagher","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajog.2023.12.040_bib11","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13059-021-02478-w","article-title":"SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits","volume":"22","author":"Zhang","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajog.2023.12.040_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ajhg.2014.11.011","article-title":"Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension","volume":"96","author":"Zhu","year":"2015","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13835","article-title":"Genetic and epigenetic fine mapping of causal autoimmune disease variants","volume":"518","author":"Farh","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2023.12.040_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib16","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajog.2023.12.040_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib18","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ng.3412","article-title":"Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair","volume":"47","author":"Day","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41591-020-0751-5","article-title":"Using human genetics to understand the disease impacts of testosterone in men and women","volume":"26","author":"Ruth","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.ajog.2023.12.040_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002805","article-title":"A\u00a0genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation","volume":"8","author":"Coviello","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.kint.2018.03.017","article-title":"Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions","volume":"94","author":"Langefeld","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajog.2023.12.040_bib22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.381","article-title":"Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes","volume":"41","author":"Barrett","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib23","article-title":"Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer","volume":"6","author":"Guo","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajog.2023.12.040_bib24","first-page":"1297","article-title":"Renalase overexpression in ER-positive breast cancer","volume":"11","author":"Yu","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.ajog.2023.12.040_bib25","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/bjc.2014.429","article-title":"Identification of 33 candidate oncogenes by screening for base-specific mutations","volume":"111","author":"Tuupanen","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajog.2023.12.040_bib26","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000015698","article-title":"ATP binding cassette subfamily B member 9 (ABCB9) is a prognostic indicator of overall survival in ovarian cancer","volume":"98","author":"Hou","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ajog.2023.12.040_bib27","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.3892\/ol.2016.5139","article-title":"Overexpression of microRNA-24 increases the sensitivity to paclitaxel in drug-resistant breast carcinoma cell lines via targeting ABCB9","volume":"12","author":"Gong","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ajog.2023.12.040_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/0022034511420723","article-title":"Double edge: CDK2AP1 in cell-cycle regulation and epigenetic regulation","volume":"91","author":"Wong","year":"2012","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1095\/biolreprod61.1.120","article-title":"Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells","volume":"61","author":"Kilpatrick","year":"1999","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajog.2023.12.040_bib30","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1158\/0008-5472.CAN-11-3701","article-title":"Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression","volume":"72","author":"Takawa","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib31","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jaci.2020.07.004","article-title":"Investigating asthma heterogeneity through shared and distinct genetics: insights from genome-wide cross-trait analysis","volume":"147","author":"Zhu","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.ajog.2023.12.040_bib32","doi-asserted-by":"crossref","first-page":"e236","DOI":"10.1038\/oncsis.2016.45","article-title":"Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma","volume":"5","author":"Patel","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ajog.2023.12.040_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13578-018-0204-8","article-title":"PML: regulation and multifaceted function beyond tumor suppression","volume":"8","author":"Hsu","year":"2018","journal-title":"Cell Biosci"},{"key":"10.1016\/j.ajog.2023.12.040_bib34","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1158\/0008-5472.CAN-15-1524","article-title":"Renalase expression by melanoma and tumor-associated macrophages promotes tumor growth through a STAT3-mediated mechanism","volume":"76","author":"Hollander","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dnarep.2019.02.003","article-title":"The MCM8\/9 complex: a recent recruit to the roster of helicases involved in genome maintenance","volume":"76","author":"Griffin","year":"2019","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.ajog.2023.12.040_bib36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41419-017-0177-2","article-title":"RAP80 is an independent prognosis biomarker for the outcome of patients with esophageal squamous cell carcinoma","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajog.2023.12.040_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.997970","article-title":"REV1: a novel biomarker and potential therapeutic target for various cancers","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib38","doi-asserted-by":"crossref","first-page":"E4315","DOI":"10.1073\/pnas.1320477111","article-title":"Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages","volume":"111","author":"Lee","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajog.2023.12.040_bib39","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3390\/cancers11060797","article-title":"The Metallophosphoesterase-domain-containing Protein 2 (MPPED2) gene acts as tumor suppressor in breast cancer","volume":"11","author":"Pellecchia","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ajog.2023.12.040_bib40","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1158\/1055-9965.EPI-17-0849","article-title":"miRNA-processing gene methylation and cancer risk","volume":"27","author":"Joyce","year":"2018","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ajog.2023.12.040_bib41","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41420-021-00668-w","article-title":"Roles and action mechanisms of WNT4 in cell differentiation and human diseases: a review","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.ajog.2023.12.040_bib42","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.4251\/wjgo.v13.i10.1367","article-title":"Diverse roles of FOXO family members in gastric cancer","volume":"13","author":"Chen","year":"2021","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.ajog.2023.12.040_bib43","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s43018-020-0056-0","article-title":"eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer","volume":"1","author":"Suresh","year":"2020","journal-title":"Nat Cancer"},{"key":"10.1016\/j.ajog.2023.12.040_bib44","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11357-016-9939-5","article-title":"Age at menarche and age at natural menopause in East Asian women: a genome-wide association study","volume":"38","author":"Shi","year":"2016","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.ajog.2023.12.040_bib45","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/jcmm.13062","article-title":"Extracellular renalase protects cells and organs by outside-in signalling","volume":"21","author":"Wang","year":"2017","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.ajog.2023.12.040_bib46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40659-020-00311-5","article-title":"MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells","volume":"53","author":"Cao","year":"2020","journal-title":"Biol Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib47","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13148-016-0268-4","article-title":"The emerging role of lysine methyltransferase SETD8 in human diseases","volume":"8","author":"Milite","year":"2016","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.ajog.2023.12.040_bib48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40659-018-0162-y","article-title":"MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma","volume":"51","author":"Wu","year":"2018","journal-title":"Biol Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.43","article-title":"Uterine fibroids","volume":"2","author":"Stewart","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ajog.2023.12.040_bib50","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bpobgyn.2007.07.005","article-title":"Hormone-dependent gynaecological disorders: a pathophysiological perspective for appropriate treatment","volume":"22","author":"Petraglia","year":"2008","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2023.12.040_bib51","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/jnci\/djr101","article-title":"Reproductive history and risk of colorectal cancer in postmenopausal women","volume":"103","author":"Zervoudakis","year":"2011","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ajog.2023.12.040_bib52","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1136\/gut.2007.129411","article-title":"Menstrual and reproductive factors and gastric cancer risk in a large prospective study of women","volume":"56","author":"Freedman","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.ajog.2023.12.040_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.863594","article-title":"Uterine fibroid patients reveal alterations in the gut microbiome","volume":"12","author":"Mao","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib54","doi-asserted-by":"crossref","first-page":"m3502","DOI":"10.1136\/bmj.m3502","article-title":"Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review","volume":"371","author":"Okoth","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2023.12.040_bib55","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/OGX.0000000000000718","article-title":"Cardiometabolic risk factors and benign gynecologic disorders","volume":"74","author":"AlAshqar","year":"2019","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.ajog.2023.12.040_bib56","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/GRF.0000000000000164","article-title":"Epidemiology of uterine fibroids: from menarche to menopause","volume":"59","author":"Wise","year":"2016","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.12.040_bib57","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1210\/jcem-57-1-82","article-title":"Early menarche, a risk factor for breast cancer, indicates early onset of ovulatory cycles","volume":"57","author":"Apter","year":"1983","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2023.12.040_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bpobgyn.2015.11.015","article-title":"Hormones and pathogenesis of uterine fibroids","volume":"34","author":"Reis","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2023.12.040_bib59","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/ijc.2910440506","article-title":"Some endocrine characteristics of early menarche, a risk factor for breast cancer, are preserved into adulthood","volume":"44","author":"Apter","year":"1989","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajog.2023.12.040_bib60","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/000456329002700603","article-title":"Sex hormone binding globulin: origin, function and clinical significance","volume":"27","author":"Selby","year":"1990","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.ajog.2023.12.040_bib61","first-page":"624","article-title":"New concepts in the treatment of uterine leiomyomas","volume":"92","author":"Stewart","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2023.12.040_bib62","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/gepi.21998","article-title":"Bias due to participant overlap in two-sample Mendelian randomization","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib63","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41467-023-35974-7","article-title":"Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata","volume":"14","author":"Sliz","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajog.2023.12.040_bib64","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib65","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13059-021-02478-w","article-title":"SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits","volume":"22","author":"Zhang","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajog.2023.12.040_bib66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ajhg.2014.11.011","article-title":"Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension","volume":"96","author":"Zhu","year":"2015","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib67","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association\u00a0and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib68","doi-asserted-by":"crossref","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib69","doi-asserted-by":"crossref","first-page":"D643","DOI":"10.1093\/nar\/gkw1022","article-title":"3DSNP: a database for linking human noncoding SNPs to their three-dimensional interacting genes","volume":"45","author":"Lu","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib70","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13835","article-title":"Genetic and epigenetic fine mapping of causal autoimmune disease variants","volume":"518","author":"Farh","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ajog.2023.12.040_bib71","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ng.2435","article-title":"Bayesian refinement of association signals for 14 loci in 3 common diseases","volume":"44","author":"Wellcome Trust Case Control Consortium","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLOS Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib73","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib74","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajog.2023.12.040_bib75","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib76","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41588-018-0092-1","article-title":"Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights","volume":"50","author":"Gusev","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajog.2023.12.040_bib77","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","article-title":"Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors","volume":"30","author":"Burgess","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib78","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib79","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib80","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib82","doi-asserted-by":"crossref","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajog.2023.12.040_bib83","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib84","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpobgyn.2017.09.004","article-title":"Epidemiology and risk factors of uterine fibroids","volume":"46","author":"Pavone","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2023.12.040_bib85","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s10654-018-0367-y","article-title":"Body mass index and age at natural menopause: an international pooled analysis of 11 prospective studies","volume":"33","author":"Zhu","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ajog.2023.12.040_bib86","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1127\/0003-5548\/2010\/0066","article-title":"Association between BMI and age at menarche in girls from different socio-economic groups","volume":"68","author":"Wronka","year":"2010","journal-title":"Anthropol Anz"},{"key":"10.1016\/j.ajog.2023.12.040_bib87","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/hmg\/ddy327","article-title":"Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry","volume":"28","author":"Pulit","year":"2019","journal-title":"Hum Mol Genet"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937824000085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937824000085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:39:22Z","timestamp":1777336762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937824000085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":87,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0002937824000085"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2023.12.040","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2023.12.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}