{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:57:18Z","timestamp":1793642238754,"version":"4.5.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"am","delay-in-days":359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","ajog.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ajog.2024.04.042","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T23:52:41Z","timestamp":1714866761000},"page":"263.e1-263.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Three-year outcomes of a randomized clinical trial of perioperative vaginal estrogen as adjunct to native tissue vaginal apical prolapse repair"],"prefix":"10.1016","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-2368","authenticated-orcid":false,"given":"David D.","family":"Rahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly E.","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian W.","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Pruszynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2024.04.042_bib1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1097\/AOG.0000000000000286","article-title":"Lifetime risk of stress urinary incontinence or pelvic organ prolapse surgery","volume":"123","author":"Wu","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib2","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/AOG.0b013e3181f73729","article-title":"Lifetime risk of undergoing surgery for pelvic organ prolapse","volume":"116","author":"Smith","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/AOG.0b013e318195888d","article-title":"Complication and reoperation rates after apical vaginal prolapse surgical repair: a systematic review","volume":"113","author":"Diwadkar","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib4","article-title":"Surgery for women with apical vaginal prolapse","volume":"10","author":"Maher","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajog.2024.04.042_bib5","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1001\/jama.2013.4919","article-title":"Long-term outcomes following abdominal sacrocolpopexy for pelvic organ prolapse","volume":"309","author":"Nygaard","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2024.04.042_bib6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ajog.2003.08.040","article-title":"Impact of menopause on collagen subtypes in the arcus tendineous fasciae pelvis","volume":"190","author":"Moalli","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/mob.2002.124845","article-title":"Regulation of matrix metalloproteinase expression by estrogen in fibroblasts that are derived from the pelvic floor","volume":"187","author":"Moalli","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib8","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1210\/jc.2014-1216","article-title":"Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial","volume":"99","author":"Rahn","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.ajog.2024.04.042_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/nau.24819","article-title":"The effects of oestrogen on vaginal wound healing: a systematic review and meta-analysis","volume":"41","author":"Vodegel","year":"2022","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.ajog.2024.04.042_bib10","article-title":"Oestrogens for treatment or prevention of pelvic organ prolapse in postmenopausal women","volume":"2010","author":"Ismail","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajog.2024.04.042_bib11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/jama.2023.12317","article-title":"Perioperative vaginal estrogen as adjunct to native tissue vaginal apical prolapse repair: a randomized clinical trial","volume":"330","author":"Rahn","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2024.04.042_bib12","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1097\/SPV.0000000000000899","article-title":"Design of a randomized clinical trial of perioperative vaginal estrogen versus placebo with transvaginal native tissue apical prolapse repair (Investigation to Minimize Prolapse Recurrence of the Vagina using Estrogen: IMPROVE)","volume":"27","author":"Rahn","year":"2021","journal-title":"Female Pelvic Med Reconstr Surg"},{"key":"10.1016\/j.ajog.2024.04.042_bib13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1001\/jama.2014.1719","article-title":"Comparison of 2 transvaginal surgical approaches and perioperative behavioral therapy for apical vaginal prolapse: the OPTIMAL randomized trial","volume":"311","author":"Barber","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2024.04.042_bib14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cct.2008.12.001","article-title":"Operations and pelvic muscle training in the management of apical support loss (OPTIMAL) trial: design and methods","volume":"30","author":"Barber","year":"2009","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.ajog.2024.04.042_bib15","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1067\/mob.2000.110910","article-title":"A\u00a0transvaginal approach to repair of apical and other associated sites of pelvic organ prolapse with uterosacral ligaments","volume":"183","author":"Shull","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib16","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/0002-9378(88)90088-9","article-title":"Sacrospinous ligament fixation for eversion of the vagina","volume":"158","author":"Morley","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ajog.2004.12.025","article-title":"Short forms of two condition-specific quality-of-life questionnaires for women with pelvic floor disorders (PFDI-20 and PFIQ-7)","volume":"193","author":"Barber","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0002-9378(96)70243-0","article-title":"The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction","volume":"175","author":"Bump","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1067\/mob.2003.379","article-title":"Validation of two global impression questionnaires for incontinence","volume":"189","author":"Yalcin","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib20","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/gme.0b013e3181a48c4e","article-title":"Efficacy and safety of low-dose regimens of conjugated estrogens cream administered vaginally","volume":"16","author":"Bachmann","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.ajog.2024.04.042_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1191\/1740774504cn049oa","article-title":"The effect of correlation structure on treatment contrasts estimated from incomplete clinical trial data with likelihood-based repeated measures compared with last observation carried forward ANOVA","volume":"1","author":"Mallinckrodt","year":"2004","journal-title":"Clin Trials"},{"key":"10.1016\/j.ajog.2024.04.042_bib22","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1001\/jama.2018.2827","article-title":"Effect of uterosacral ligament suspension vs sacrospinous ligament fixation with or without perioperative behavioral therapy for pelvic organ vaginal prolapse on surgical outcomes and prolapse symptoms at 5 years in the OPTIMAL randomized clinical trial","volume":"319","author":"Jelovsek","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2024.04.042_bib23","first-page":"195","article-title":"Obesity as a risk for the recurrence of anterior vaginal wall prolapse after anterior colporrhaphy","volume":"58","author":"Kawasaki","year":"2013","journal-title":"J\u00a0Reprod Med"},{"key":"10.1016\/j.ajog.2024.04.042_bib24","doi-asserted-by":"crossref","first-page":"252.e1","DOI":"10.1016\/j.ajog.2022.04.017","article-title":"Risk factors for pelvic organ prolapse recurrence after sacrospinous hysteropexy or vaginal hysterectomy with uterosacral ligament suspension","volume":"227","author":"Schulten","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib25","doi-asserted-by":"crossref","first-page":"718.e1","DOI":"10.1016\/j.ajog.2015.12.027","article-title":"Genital hiatus size is associated with and predictive of apical vaginal support loss","volume":"214","author":"Lowder","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijgo.2007.11.008","article-title":"Wide genital hiatus is a risk factor for recurrence following anterior vaginal repair","volume":"101","author":"Medina","year":"2008","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajog.2024.04.042_bib27","first-page":"312","article-title":"Characteristics associated with surgical failure after native tissue apical prolapse repair","volume":"143","author":"Rahn","year":"2024","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ajog.2022.04.046","article-title":"Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis","volume":"227","author":"Schulten","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib29","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.ajog.2004.06.109","article-title":"Risk factors for prolapse recurrence after vaginal repair","volume":"191","author":"Whiteside","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2023.05.023","article-title":"Effects of preoperative intravaginal estrogen on pelvic floor disorder symptoms in postmenopausal women with pelvic organ prolapse","volume":"229","author":"Rahn","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2024.04.042_bib31","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/GME.0000000000000840","article-title":"Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall","volume":"24","author":"Ripperda","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.ajog.2024.04.042_bib32","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S1357-2725(98)00058-2","article-title":"The role of apoptosis in wound healing","volume":"30","author":"Greenhalgh","year":"1998","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ajog.2024.04.042_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.ajog.2024.04.042_bib34","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/AOG.0b013e3181b2b1ae","article-title":"Defining success after surgery for pelvic organ prolapse","volume":"114","author":"Barber","year":"2009","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937824005684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937824005684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T16:39:14Z","timestamp":1728405554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937824005684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0002937824005684"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2024.04.042","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Three-year outcomes of a randomized clinical trial of perioperative vaginal estrogen as adjunct to native tissue vaginal apical prolapse repair","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2024.04.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}