{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:12:35Z","timestamp":1791843155346,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ajog.2025.01.001","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T07:30:26Z","timestamp":1735975826000},"page":"66.e1-66.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of umbilical vein blood flow assessment in the prediction of fetal growth velocity and adverse outcome: a prospective observational cohort study"],"prefix":"10.1016","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-659X","authenticated-orcid":false,"given":"Daniele","family":"Farsetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Magni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Zamagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Monasta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"Maso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vasapollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pometti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Maria","family":"Ferrazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Valensise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Stampalija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2025.01.001_bib1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ajog.2021.11.1357","article-title":"Clinical Opinion: the diagnosis and management of suspected fetal growth restriction: an evidence-based approach","volume":"226","author":"Lees","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/uog.11112","article-title":"Neurodevelopmental delay in small babies at term: a systematic review","volume":"40","author":"Arcangeli","year":"2012","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/uog.14644","article-title":"Human fetal growth is constrained below optimal for perinatal survival","volume":"45","author":"Vasak","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/uog.22134","article-title":"ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction","volume":"56","author":"Lees","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/uog.15884","article-title":"Consensus definition of fetal growth restriction: a Delphi procedure","volume":"48","author":"Gordijn","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib6","doi-asserted-by":"crossref","first-page":"71.e1","DOI":"10.1016\/j.ajog.2022.06.023","article-title":"Reduced fetal growth velocity and weight loss are associated with adverse perinatal outcome in fetuses at risk of growth restriction","volume":"228","author":"Stampalija","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S2352-4642(18)30129-9","article-title":"Screening for fetal growth restriction using ultrasound and the sFLT1\/PlGF ratio in nulliparous women: a prospective cohort study","volume":"2","author":"Gaccioli","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.ajog.2025.01.001_bib8","doi-asserted-by":"crossref","first-page":"224.e1","DOI":"10.1016\/j.ajog.2024.04.033","article-title":"Validity of a Delphi consensus definition of growth restriction in the newborn for identifying neonatal morbidity","volume":"232","author":"Monier","year":"2025","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejogrb.2020.12.023","article-title":"Fetal weight change close to term is proportional to the birthweight percentile","volume":"257","author":"Stephens","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2025.01.001_bib10","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1111\/aogs.13645","article-title":"Comparing the relation between ultrasound-estimated fetal weight and birthweight in cohort of small-for-gestational-age fetuses","volume":"98","author":"Stephens","year":"2019","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2025.01.001_bib11","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1046\/j.1469-0705.2000.00208.x","article-title":"Umbilical vein blood flow in growth-restricted fetuses","volume":"16","author":"Ferrazzi","year":"2000","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jcu.23412","article-title":"Umbilical vein blood flow: state-of-the-art","volume":"51","author":"Barbieri","year":"2023","journal-title":"J Clin Ultrasound"},{"key":"10.1016\/j.ajog.2025.01.001_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.placenta.2024.04.014","article-title":"Nitric oxide donor increases umbilical vein blood flow and fetal oxygenation in fetal growth restriction. A pilot study","volume":"151","author":"Farsetti","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.ajog.2025.01.001_bib14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/uog.5306","article-title":"Umbilical venous blood flow measurement: accuracy and reproducibility","volume":"32","author":"Figueras","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib15","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.3390\/jcm12093132","article-title":"Umbilical vein blood flow in uncomplicated pregnancies: systematic review of available reference charts and comparison with a new cohort","volume":"12","author":"Barbieri","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.ajog.2025.01.001_bib16","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.1080\/14767058.2021.1918091","article-title":"Distinction between SGA and FGR by means of fetal umbilical vein flow and maternal hemodynamics","volume":"35","author":"Farsetti","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajog.2025.01.001_bib17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/jum.15993","article-title":"Umbilical venous volume flow in late-onset fetal growth restriction","volume":"42","author":"Hamidi","year":"2023","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.ajog.2025.01.001_bib18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ajog.2025.01.001_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9378(85)90298-4","article-title":"Estimation of fetal weight with the use of head, body, and femur measurements--a prospective study","volume":"151","author":"Hadlock","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/uog.23698","article-title":"ISUOG Practice Guidelines (updated): use of Doppler velocimetry in obstetrics","volume":"58","author":"Bhide","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejogrb.2022.03.032","article-title":"Late-term fetuses with reduced umbilical vein blood flow volume: an under-recognized population at increased risk of growth restriction","volume":"272","author":"Stampalija","year":"2022","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2025.01.001_bib22","article-title":"The world Health organization fetal growth charts: a multinational longitudinal study of ultrasound biometric measurements and estimated fetal weight","volume":"14","author":"Kiserud","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.ajog.2025.01.001_bib23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/jpme.1990.18.3.165","article-title":"Normal values of pulsatility index from fetal vessels: a cross-sectional study on 1556 healthy fetuses","volume":"18","author":"Arduini","year":"1990","journal-title":"J Perinat Med"},{"key":"10.1016\/j.ajog.2025.01.001_bib24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/uog.5315","article-title":"Reference ranges for uterine artery mean pulsatility index at 11-41 weeks of gestation","volume":"32","author":"G\u00f3mez","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ajog.2025.01.001_bib25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1148\/radiology.181.1.1887021","article-title":"In utero analysis of fetal growth: a sonographic weight standard","volume":"181","author":"Hadlock","year":"1991","journal-title":"Radiology"},{"key":"10.1016\/j.ajog.2025.01.001_bib26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/MPG.0b013e3181da213e","article-title":"Neonatal anthropometric charts: the Italian neonatal study compared with other European studies","volume":"51","author":"Bertino","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.ajog.2025.01.001_bib27","article-title":"Calculating the sample size required for developing a clinical prediction model","volume":"368","author":"Riley","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.ajog.2025.01.001_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/uog.20854","article-title":"Validation of Delphi procedure consensus criteria for defining fetal growth restriction","volume":"56","author":"Molina","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2023.101117","article-title":"Do differences in diagnostic criteria for late fetal growth restriction matter?","volume":"5","author":"Mylrea-Foley","year":"2023","journal-title":"Am J Obstet Gynecol MFM"},{"key":"10.1016\/j.ajog.2025.01.001_bib30","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/1471-0528.13607","article-title":"Brain sparing effect in growth-restricted fetuses is associated with decreased cardiac acceleration and deceleration capacities: a case\u2013control study","volume":"123","author":"Stampalija","year":"2016","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2025.01.001_bib31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/uog.20103","article-title":"Premature placental aging in term small-for-gestational-age and growth-restricted fetuses","volume":"53","author":"Paules","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib32","doi-asserted-by":"crossref","first-page":"S656","DOI":"10.1016\/j.ajog.2017.12.210","article-title":"Individualized growth assessment: conceptual framework and practical implementation for the evaluation of fetal growth and neonatal growth outcome","volume":"218","author":"Deter","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib33","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/S0140-6736(15)00131-2","article-title":"Screening for fetal growth restriction with universal third trimester ultrasonography in nulliparous women in the Pregnancy Outcome Prediction (POP) study: a prospective cohort study","volume":"386","author":"Sovio","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2025.01.001_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/uog.15835","article-title":"Prediction of adverse perinatal outcome of small-for-gestational-age pregnancy using size centiles and conditional growth centiles","volume":"48","author":"Karlsen","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/uog.7699","article-title":"First-trimester umbilical vein blood flow in pregnancies with low serum pregnancy-associated plasma protein-A levels: an early predictor of fetal growth restriction","volume":"36","author":"Rizzo","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib36","doi-asserted-by":"crossref","first-page":"222.e1","DOI":"10.1016\/j.ajog.2022.08.004","article-title":"The cardiac-fetal-placental unit: fetal umbilical vein flow rate is linked to the maternal cardiac profile in fetal growth restriction","volume":"228","author":"Valensise","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/reprodmed2010006","article-title":"Fetal umbilical vein flow in the classification of fetuses with growth restriction","volume":"2","author":"Farsetti","year":"2021","journal-title":"Reprod Med"},{"key":"10.1016\/j.ajog.2025.01.001_bib38","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1067\/mob.2001.117356","article-title":"Early and persistent reduction in umbilical vein blood flow in the growth-restricted fetus: a longitudinal study","volume":"185","author":"Rigano","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib39","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/uog.27534","article-title":"Association of umbilical vein flow with abnormal fetal growth and adverse perinatal outcome in low-risk population: multicenter prospective study","volume":"63","author":"Ramirez Zegarra","year":"2024","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib40","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/uog.23664","article-title":"Diagnosis and management of fetal growth restriction: the ISUOG guideline and comparison with the SMFM guideline","volume":"57","author":"Lees","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib41","doi-asserted-by":"crossref","first-page":"290.e1","DOI":"10.1016\/j.ajog.2013.02.007","article-title":"Optimizing the definition of intrauterine growth restriction: the multicenter prospective PORTO Study","volume":"208","author":"Unterscheider","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejogrb.2007.02.016","article-title":"Small-for-gestational-age fetuses with normal umbilical artery Doppler have suboptimal perinatal and neurodevelopmental outcome","volume":"136","author":"Figueras","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajog.2025.01.001_bib43","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/uog.5389","article-title":"Low cardiac output to the placenta: an early hemodynamic adaptive mechanism in intrauterine growth restriction","volume":"32","author":"Rizzo","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib44","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1095-6433(98)01010-1","article-title":"Metabolic and circulatory adaptations to chronic hypoxia in the fetus","volume":"119","author":"Richardson","year":"1998","journal-title":"Comp Biochem Physiol Mol Integr Physiol"},{"key":"10.1016\/j.ajog.2025.01.001_bib45","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00006250-199203000-00018","article-title":"Cerebral-umbilical Doppler ratio as a predictor of adverse perinatal outcome","volume":"79","author":"Gramellini","year":"1992","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.01.001_bib46","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1471-0528.1986.tb08654.x","article-title":"Fetal volume blood flow and umbilical artery flow velocity waveform analysis: a comparison","volume":"93","author":"Giles","year":"1986","journal-title":"Br J Obstet Gynaecol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937825000018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937825000018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T03:23:06Z","timestamp":1751599386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937825000018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0002937825000018"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2025.01.001","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of umbilical vein blood flow assessment in the prediction of fetal growth velocity and adverse outcome: a prospective observational cohort study","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2025.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}