{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:56:58Z","timestamp":1787241418941,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FPU19\/0496"],"award-info":[{"award-number":["FPU19\/0496"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016386","name":"Government of Valencia Ministry of Innovation Universities Science and Society","doi-asserted-by":"publisher","award":["CIPROM\/2021\/058"],"award-info":[{"award-number":["CIPROM\/2021\/058"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI21\/00170"],"award-info":[{"award-number":["PI21\/00170"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CD20\/00116"],"award-info":[{"award-number":["CD20\/00116"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ajog.2025.02.006","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T14:47:33Z","timestamp":1738939653000},"page":"112.e1-112.e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Nicotinamide mononucleotide supplementation improves oocyte developmental competence in different ovarian damage conditions"],"prefix":"10.1016","volume":"233","author":[{"given":"Noelia","family":"Ram\u00edrez-Mart\u00edn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Buigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rodr\u00edguez-Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Bl\u00e1zquez-Sim\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rodr\u00edguez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Pellicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pellicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Escrib\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-6922","authenticated-orcid":false,"given":"Sonia","family":"Herraiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2025.02.006_bib1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: an overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajog.2025.02.006_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005402","article-title":"Cyclophosphamide triggers follicle activation and \"burnout\"; AS101 prevents follicle loss and preserves fertility","volume":"5","author":"Kalich-Philosoph","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajog.2025.02.006_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/humupd\/dmy002","article-title":"The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing","volume":"24","author":"Winship","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2025.02.006_bib4","article-title":"Cyclophosphamide exposure causes long-term detrimental effect of oocytes developmental competence through affecting the epigenetic modification and maternal factors' transcription during oocyte growth","volume":"9","author":"Yang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.ajog.2025.02.006_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD(+) metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajog.2025.02.006_bib6","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.celrep.2020.01.058","article-title":"NAD(+) repletion rescues female fertility during reproductive aging","volume":"30","author":"Bertoldo","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajog.2025.02.006_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fcell.2020.00246","article-title":"Nicotinamide mononucleotide: a promising molecule for therapy of diverse diseases by targeting NAD+ metabolism","volume":"8","author":"Hong","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.ajog.2025.02.006_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jare.2021.08.003","article-title":"Nicotinamide mononucleotide (NMN) as an anti-aging health product - promises and safety concerns","volume":"37","author":"Nadeeshani","year":"2022","journal-title":"J Adv Res"},{"key":"10.1016\/j.ajog.2025.02.006_bib9","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1038\/s44321-024-00119-w","article-title":"Fertility protection during chemotherapy treatment by boosting the NAD(P)(+) metabolome","volume":"16","author":"Ho","year":"2024","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.ajog.2025.02.006_bib10","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s43032-020-00191-w","article-title":"Diminished ovarian reserve chemotherapy-induced mouse model: a tool for the preclinical assessment of new therapies for ovarian damage","volume":"27","author":"Buigues","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajog.2025.02.006_bib11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.fertnstert.2018.01.004","article-title":"Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion","volume":"109","author":"Herraiz","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2025.02.006_bib12","doi-asserted-by":"crossref","first-page":"65.e1","DOI":"10.1016\/j.ajog.2021.01.023","article-title":"Stem cell-secreted factor therapy regenerates the ovarian niche and rescues follicles","volume":"225","author":"Buigues","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.02.006_bib13","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1093\/humrep\/deab165","article-title":"The cyto-protective effects of LH on ovarian reserve and female fertility during exposure to gonadotoxic alkylating agents in an adult mouse model","volume":"36","author":"Del Castillo","year":"2021","journal-title":"Hum reprod (Oxford, England)"},{"key":"10.1016\/j.ajog.2025.02.006_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.actbio.2024.07.056","article-title":"Growth factor-loaded ovarian extracellular matrix hydrogels promote in vivo ovarian niche regeneration and enhance fertility in premature ovarian insufficiency preclinical models","volume":"186","author":"Franc\u00e9s-Herrero","year":"2024","journal-title":"Acta Biomater"},{"key":"10.1016\/j.ajog.2025.02.006_bib15","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.rbmo.2018.08.023","article-title":"Do immature and mature sibling oocytes recovered from stimulated cycles have the same reproductive potential?","volume":"37","author":"Escrich","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ajog.2025.02.006_bib16","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.fertnstert.2012.07.1116","article-title":"The dynamics of in vitro maturation of germinal vesicle oocytes","volume":"98","author":"Escrich","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2025.02.006_bib17","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1530\/jrf.0.0170555","article-title":"Proposal for a classification of oocytes and follicles in the mouse ovary","volume":"17","author":"Pedersen","year":"1968","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.ajog.2025.02.006_bib18","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/hmg\/ddt486","article-title":"Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions","volume":"23","author":"Zheng","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajog.2025.02.006_bib19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/humupd\/dmx035","article-title":"Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors","volume":"24","author":"Greaney","year":"2018","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajog.2025.02.006_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107987","article-title":"Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes","volume":"32","author":"Miao","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajog.2025.02.006_bib21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJMoa1616361","article-title":"NAD deficiency, congenital malformations, and niacin supplementation","volume":"377","author":"Shi","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2025.02.006_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12929-016-0253-4","article-title":"Impact of stress on oocyte quality and reproductive outcome","volume":"23","author":"Prasad","year":"2016","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.ajog.2025.02.006_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1477-7827-3-28","article-title":"Role of oxidative stress in female reproduction","volume":"3","author":"Agarwal","year":"2005","journal-title":"Reprod Biol Endocrinol : RB&E"},{"key":"10.1016\/j.ajog.2025.02.006_bib24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s10495-005-0367-8","article-title":"Hydrogen peroxide modulates meiotic cell cycle and induces morphological features characteristic of apoptosis in rat oocytes cultured in vitro","volume":"10","author":"Chaube","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.ajog.2025.02.006_bib25","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S1472-6483(10)60038-7","article-title":"Could oxidative stress influence the in-vitro maturation of oocytes?","volume":"18","author":"Combelles","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ajog.2025.02.006_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1477-7827-7-40","article-title":"Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics","volume":"7","author":"Revelli","year":"2009","journal-title":"Reprod Biol Endocrinol : RB&E"},{"key":"10.1016\/j.ajog.2025.02.006_bib27","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1600-079X.2007.00524.x","article-title":"Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate","volume":"44","author":"Tamura","year":"2008","journal-title":"J Pineal Res"},{"key":"10.1016\/j.ajog.2025.02.006_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0070-2153(06)77002-8","article-title":"The role of mitochondrial function in the oocyte and embryo","volume":"77","author":"Dumollard","year":"2007","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.ajog.2025.02.006_bib29","first-page":"105","article-title":"Oocyte quality and aging","volume":"26","author":"Moghadam","year":"2022","journal-title":"JBRA Assis Reprod"},{"key":"10.1016\/j.ajog.2025.02.006_bib30","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jcp.22171","article-title":"Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation","volume":"224","author":"Yu","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajog.2025.02.006_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","article-title":"NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus","volume":"22","author":"Cant\u00f3","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajog.2025.02.006_bib32","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1101\/gad.328105","article-title":"Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes","volume":"19","author":"Homer","year":"2005","journal-title":"Genes & development"},{"key":"10.1016\/j.ajog.2025.02.006_bib33","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1093\/oxfordjournals.humrep.a019080","article-title":"Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women","volume":"11","author":"Battaglia","year":"1996","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ajog.2025.02.006_bib34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41419-019-1578-1","article-title":"AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair","volume":"10","author":"Pei","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajog.2025.02.006_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-0040-1721377","article-title":"The role of oocyte quality in explaining \"unexplained\" infertility","volume":"38","author":"Homer","year":"2020","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.ajog.2025.02.006_bib36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ando.2010.02.021","article-title":"Human ovarian follicular development: from activation of resting follicles to preovulatory maturation","volume":"71","author":"Gougeon","year":"2010","journal-title":"Ann Endocrinol"},{"key":"10.1016\/j.ajog.2025.02.006_bib37","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s43032-020-00191-w","article-title":"Diminished ovarian reserve chemotherapy-induced mouse model: a tool for the preclinical assessment of new therapies for ovarian damage","volume":"27","author":"Buigues","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajog.2025.02.006_bib38","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.celrep.2020.01.058","article-title":"NAD(+) repletion rescues female fertility during reproductive aging","volume":"30","author":"Bertoldo","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajog.2025.02.006_bib39","doi-asserted-by":"crossref","first-page":"65.e1","DOI":"10.1016\/j.ajog.2021.01.023","article-title":"Stem cell-secreted factor therapy regenerates the ovarian niche and rescues follicles","volume":"225","author":"Buigues","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.02.006_bib40","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.rbmo.2018.08.023","article-title":"Do immature and mature sibling oocytes recovered from stimulated cycles have the same reproductive potential?","volume":"37","author":"Escrich","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ajog.2025.02.006_bib41","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.fertnstert.2012.07.1116","article-title":"The dynamics of in vitro maturation of germinal vesicle oocytes","volume":"98","author":"Escrich","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2025.02.006_bib42","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.fertnstert.2018.01.004","article-title":"Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion","volume":"109","author":"Herraiz","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajog.2025.02.006_bib43","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1093\/humrep\/deab165","article-title":"The cyto-protective effects of LH on ovarian reserve and female fertility during exposure to gonadotoxic alkylating agents in an adult mouse model","volume":"36","author":"Del Castillo","year":"2021","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ajog.2025.02.006_bib44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.actbio.2024.07.056","article-title":"Growth factor-loaded ovarian extracellular matrix hydrogels promote in vivo ovarian niche regeneration and enhance fertility in premature ovarian insufficiency preclinical models","volume":"186","author":"Franc\u00e9s-Herrero","year":"2024","journal-title":"Acta Biomater"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937825000870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937825000870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:15:20Z","timestamp":1778544920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937825000870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0002937825000870"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2025.02.006","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinamide mononucleotide supplementation improves oocyte developmental competence in different ovarian damage conditions","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2025.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}