{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:44:04Z","timestamp":1791492244998,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ajog.2025.11.018","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:14:51Z","timestamp":1763644491000},"page":"1130-1147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early prediction of congenital cytomegalovirus infection and symptoms after maternal primary infection: an in vivo study using cytomegalovirus polymerase chain reaction in chorionic villi and in amniotic fluid"],"prefix":"10.1016","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3093-4085","authenticated-orcid":false,"given":"Nicolas","family":"Bourgon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Fourgeaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Daclin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"L\u0153uillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Bessieres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Faure-Bardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Guilleminot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bussieres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Magny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Leruez-Ville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-267X","authenticated-orcid":false,"given":"Yves","family":"Ville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2025.11.018_bib1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection","volume":"17","author":"Dollard","year":"2007","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.ajog.2025.11.018_bib2","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1542\/peds.2014-1173","article-title":"Hearing loss and congenital CMV infection: a systematic review","volume":"134","author":"Goderis","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2025.11.018_bib3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jcv.2005.09.015","article-title":"Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome","volume":"35","author":"Pass","year":"2006","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ajog.2025.11.018_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ajog.2020.02.018","article-title":"Cytomegalovirus infection during pregnancy: state of the science","volume":"223","author":"Leruez-Ville","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1086\/526499","article-title":"Human cytomegalovirus (HCMV) DNAemia in the mother at amniocentesis as a risk factor for iatrogenic HCMV infection of the fetus","volume":"197","author":"Revello","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajog.2025.11.018_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/uog.26128","article-title":"Neonatal and long-term outcomes of infants with congenital cytomegalovirus infection and negative amniocentesis: systematic review and meta-analysis","volume":"61","author":"Chatzakis","year":"2023","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/cid\/ciac482","article-title":"Prevalence, outcome, and prevention of congenital cytomegalovirus infection in neonates born to women with preconception immunity (CHILd study)","volume":"76","author":"Lilleri","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2025.11.018_bib8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/cid\/cix337","article-title":"Risk factors for congenital cytomegalovirus infection following primary and nonprimary maternal infection: a prospective neonatal screening study using polymerase chain reaction in saliva","volume":"65","author":"Leruez-Ville","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2025.11.018_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.909646","article-title":"Universal newborn screening for congenital cytomegalovirus infection\u2014from infant to maternal infection: a prospective multicenter study","volume":"10","author":"Chiereghin","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.ajog.2025.11.018_bib10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jcv.2007.10.015","article-title":"New advances in the diagnosis of congenital cytomegalovirus infection","volume":"41","author":"Lazzarotto","year":"2008","journal-title":"J Clin Virol"},{"issue":"Suppl4","key":"10.1016\/j.ajog.2025.11.018_bib11","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1093\/cid\/cit629","article-title":"Congenital cytomegalovirus infection: clinical outcome","volume":"57","author":"Boppana","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2025.11.018_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/rmv.535","article-title":"Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection","volume":"17","author":"Kenneson","year":"2007","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.ajog.2025.11.018_bib13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1086\/649903","article-title":"Cytomegalovirus reinfections in healthy seroimmune women","volume":"201","author":"Ross","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajog.2025.11.018_bib14","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1056\/NEJM200105033441804","article-title":"Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity","volume":"344","author":"Boppana","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajog.2025.11.018_bib15","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1093\/cid\/ciy1128","article-title":"Sequelae of congenital cytomegalovirus following maternal primary infections are limited to those acquired in the first trimester of pregnancy","volume":"69","author":"Faure-Bardon","year":"2019","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2025.11.018_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/CMR.00023-08","article-title":"Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention","volume":"22","author":"Cheeran","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ajog.2025.11.018_bib17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bpobgyn.2016.10.005","article-title":"Fetal cytomegalovirus infection","volume":"38","author":"Leruez-Ville","year":"2017","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib18","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1128\/JVI.74.15.6808-6820.2000","article-title":"Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis","volume":"74","author":"Fisher","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.ajog.2025.11.018_bib19","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/pd.5025","article-title":"Prenatal diagnosis of congenital cytomegalovirus infection in 115 cases: a 5 years\u2019 single center experience","volume":"37","author":"Enders","year":"2017","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2025.11.018_bib20","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/uog.23608","article-title":"First-trimester diagnosis of congenital cytomegalovirus infection after maternal primary infection in early pregnancy: feasibility study of viral genome amplification by PCR on chorionic villi obtained by CVS","volume":"57","author":"Faure-Bardon","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0140-6736(20)31868-7","article-title":"Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial","volume":"396","author":"Shahar-Nissan","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ajog.2025.11.018_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ajog.2023.07.022","article-title":"The effect of valacyclovir on secondary prevention of congenital cytomegalovirus infection, following primary maternal infection acquired periconceptionally or in the first trimester of pregnancy. An individual patient data meta-analysis","volume":"230","author":"Chatzakis","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib23","article-title":"Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)","volume":"40","author":"Leruez-Ville","year":"2024","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.ajog.2025.11.018_bib24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/jama.2018.9396","article-title":"Effect of cell-free DNA screening vs direct invasive diagnosis on miscarriage rates in women with pregnancies at high risk of trisomy 21: a randomized clinical Trial","volume":"320","author":"Malan","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.ajog.2025.11.018_bib25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/uog.20353","article-title":"Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis","volume":"54","author":"Salomon","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib26","doi-asserted-by":"crossref","first-page":"462.e1","DOI":"10.1016\/j.ajog.2016.04.003","article-title":"In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study","volume":"215","author":"Leruez-Ville","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.arcped.2020.01.006","article-title":"Outcome and management of newborns with congenital cytomegalovirus infection","volume":"27","author":"Nicloux","year":"2020","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.ajog.2025.11.018_bib28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10024-003-1004-6","article-title":"Standards for dysmorphological diagnosis in human fetuses","volume":"6","author":"Guihard-Costa","year":"2003","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.ajog.2025.11.018_bib29","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/pd.5757","article-title":"Is it time for routine prenatal serological screening for congenital cytomegalovirus?","volume":"40","author":"Leruez-Ville","year":"2020","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ajog.2025.11.018_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2021.100355","article-title":"Is it time to adopt routine cytomegalovirus screening in pregnancy? No","volume":"3","author":"Hui","year":"2021","journal-title":"Am J Obstet Gynecol MFM"},{"key":"10.1016\/j.ajog.2025.11.018_bib31","article-title":"Current evidence gaps to support systematic cytomegalovirus screening in pregnancy","volume":"78","author":"Billette de Villemeur AB de","year":"2024","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.ajog.2025.11.018_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/uog.26039","article-title":"New data on efficacy of valacyclovir in secondary prevention of maternal-fetal transmission of cytomegalovirus","volume":"61","author":"Egloff","year":"2023","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib33","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/uog.23685","article-title":"Secondary prevention of congenital cytomegalovirus infection with valacyclovir following maternal primary infection in early pregnancy","volume":"58","author":"Faure-Bardon","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/cid\/ciw237","article-title":"Clinical implications for children born with congenital cytomegalovirus infection following a negative amniocentesis","volume":"63","author":"Bilavsky","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajog.2025.11.018_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005547","article-title":"PPAR\u03b3 is activated during congenital cytomegalovirus infection and inhibits neuronogenesis from human neural stem cells","volume":"12","author":"Rolland","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajog.2025.11.018_bib36","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-3095","article-title":"Hearing loss with congenital cytomegalovirus infection","volume":"144","author":"Foulon","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajog.2025.11.018_bib37","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00401-011-0895-y","article-title":"Inner ear lesions in congenital cytomegalovirus infection of human fetuses","volume":"122","author":"Teissier","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ajog.2025.11.018_bib38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/2051-5960-1-63","article-title":"Human fetal inner ear involvement in congenital cytomegalovirus infection","volume":"1","author":"Gabrielli","year":"2013","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.ajog.2025.11.018_bib39","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1471-0528.2007.01308.x","article-title":"Maternal administration of valaciclovir in symptomatic intrauterine cytomegalovirus infection","volume":"114","author":"Jacquemard","year":"2007","journal-title":"BJOG"},{"key":"10.1016\/j.ajog.2025.11.018_bib40","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/uog.26136","article-title":"Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis","volume":"61","author":"D\u2019Antonio","year":"2023","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ajog.2025.11.018_bib41","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tim.2005.02.009","article-title":"Insights into viral transmission at the uterine-placental interface","volume":"13","author":"Pereira","year":"2005","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.ajog.2025.11.018_bib42","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00430-019-00613-w","article-title":"Survey of cellular immune responses to human cytomegalovirus infection in the microenvironment of the uterine-placental interface","volume":"208","author":"Tabata","year":"2019","journal-title":"Med Microbiol Immunol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937825008543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937825008543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:40:24Z","timestamp":1787380824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937825008543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0002937825008543"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2025.11.018","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early prediction of congenital cytomegalovirus infection and symptoms after maternal primary infection: an in vivo study using cytomegalovirus polymerase chain reaction in chorionic villi and in amniotic fluid","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2025.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}