{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:44:32Z","timestamp":1792125872206,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajog.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ajog.2026.09.044","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:20:47Z","timestamp":1791008447000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival outcomes of ovarian-sparing surgery for early-stage adult granulosa cell tumor"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1872-3958","authenticated-orcid":false,"given":"Fiamma L.","family":"Van Biema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6248-2832","authenticated-orcid":false,"given":"Yongmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7535-642X","authenticated-orcid":false,"given":"Delanie","family":"Ludmir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6021-5154","authenticated-orcid":false,"given":"Kevin J.","family":"Rouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9144-7861","authenticated-orcid":false,"given":"Shayan","family":"Dioun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2362-9525","authenticated-orcid":false,"given":"Alexandre","family":"Buckley de Meritens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-0310","authenticated-orcid":false,"given":"Thomas","family":"Randall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-2628","authenticated-orcid":false,"given":"Tarah","family":"Pua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6098-3300","authenticated-orcid":false,"given":"Caryn M.","family":"St. Clair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7938-2459","authenticated-orcid":false,"given":"June Y.","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-8701","authenticated-orcid":false,"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8807-153X","authenticated-orcid":false,"given":"Dawn L.","family":"Hershman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-825X","authenticated-orcid":false,"given":"Jason D.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6519-1731","authenticated-orcid":false,"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajog.2026.09.044_bib1","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1111\/aogs.14189","article-title":"Progress in the management of ovarian granulosa cell tumor: a review","volume":"100","author":"Li","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ajog.2026.09.044_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2007.08.007","article-title":"Granulosa cell tumor of the ovary","volume":"34","author":"Pectasides","year":"2008","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ajog.2026.09.044_bib3","series-title":"StatPearls [Internet]","article-title":"Granulosa theca cell tumors of the ovary","author":"Shamsudeen","year":"2023"},{"key":"10.1016\/j.ajog.2026.09.044_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/onco5020020","article-title":"A regional experience of adult granulosa cell tumours: a retrospective analysis","volume":"5","author":"Moffatt","year":"2025","journal-title":"Onco"},{"key":"10.1016\/j.ajog.2026.09.044_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ygyno.2018.09.004","article-title":"Analysis of oncologic and reproductive outcomes after fertility-sparing surgery in apparent stage I adult ovarian granulosa cell tumors","volume":"151","author":"Wang","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/bjc.2013.241","article-title":"Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary","volume":"109","author":"Mangili","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajog.2026.09.044_bib7","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1186\/s12885-024-13069-w","article-title":"Clinical features and survival rate of patients with ovarian granulosa cell tumor in Iran; a 10-year retrospective study","volume":"24","author":"Mousavi","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ajog.2026.09.044_bib8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ygyno.2018.05.013","article-title":"Estrogen receptor \u03b2: potential target for therapy in adult granulosa cell tumors?","volume":"150","author":"Ciucci","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ygyno.2017.05.020","article-title":"Ovarian granulosa cell tumor: a National Cancer Database study","volume":"146","author":"Seagle","year":"2017","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib10","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/AOG.0b013e3182864350","article-title":"Long-term mortality associated with oophorectomy compared with ovarian conservation in the nurses\u2019 health study","volume":"121","author":"Parker","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajog.2026.09.044_bib11","series-title":"NCCN guidelines for patients: ovarian cancer","year":"2025"},{"key":"10.1016\/j.ajog.2026.09.044_bib12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jpag.2021.12.005","article-title":"Analysis of outcomes and prognostic factors after fertility-sparing surgery in patients with early stage juvenile granulosa cell tumor of the ovary: experience from a tertiary center","volume":"35","author":"Wang","year":"2022","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.ajog.2026.09.044_bib14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1245\/s10434-007-9747-3","article-title":"The national cancer data base: a powerful initiative to improve cancer care in the United States","volume":"15","author":"Bilimoria","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib15","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1007\/s10147-025-02897-w","article-title":"Stage IA and IC adult granulosa cell tumors: clinical features, long-term outcomes and prognostic factors in a 333-patient cohort over three decades","volume":"30","author":"Gan","year":"2025","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3802\/jgo.2011.22.3.188","article-title":"Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective study","volume":"22","author":"Lee","year":"2011","journal-title":"J Gynecol Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ygyno.2019.05.029","article-title":"Conservative surgery in stage I adult type granulosa cells tumors of the ovary: results from the MITO-9 study","volume":"154","author":"Bergamini","year":"2019","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.11604\/pamj.2024.47.58.38324","article-title":"Granulosa cell tumor of the ovary: a series of 6 cases","volume":"47","author":"da Costa","year":"2024","journal-title":"Pan Afr Med J"},{"issue":"11","key":"10.1016\/j.ajog.2026.09.044_bib19","first-page":"e31045","article-title":"Adult-Type Ovarian Granulosa Cell Tumour: Treatment Outcomes From a Single-Institution Experience","volume":"14","author":"Alhusaini","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.ajog.2026.09.044_bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3802\/jgo.2009.20.3.158","article-title":"Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases","volume":"20","author":"Ayhan","year":"2009","journal-title":"J Gynecol Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jso.2930550203","article-title":"Granulosa cell tumor of the ovary: a study of 18 cases","volume":"55","author":"Piura","year":"1994","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1006\/gyno.2001.6183","article-title":"Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease","volume":"81","author":"Lauszus","year":"2001","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajog.2026.09.044_bib23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1046\/j.1525-1438.1997.00417.x","article-title":"Adult granulosa-cell tumor of the ovary: a retrospective study of 45 cases","volume":"7","author":"Pautier","year":"1997","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ajog.2026.09.044_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/gme.0b013e31818888f7","article-title":"Increased cardiovascular mortality after early bilateral oophorectomy","volume":"16","author":"Rivera","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.ajog.2026.09.044_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/GCO.0000000000000238","article-title":"Hormone replacement therapy after treatment for a gynaecological malignancy","volume":"28","author":"O\u2019Donnell","year":"2016","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.ajog.2026.09.044_bib26","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1111\/jog.14805","article-title":"Retrospective analysis of clinicopathological characteristics of 19 ovarian juvenile granulosa cell tumor cases","volume":"47","author":"Ndhlovu","year":"2021","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.ajog.2026.09.044_bib27","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ejso.2021.02.003","article-title":"Stage I juvenile granulosa cell tumors of the ovary: a multicentre analysis from the MITO-9 study","volume":"47","author":"Bergamini","year":"2021","journal-title":"Eur J Surg Oncol"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937826005399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937826005399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:53:43Z","timestamp":1792122823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937826005399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":26,"alternative-id":["S0002937826005399"],"URL":"https:\/\/doi.org\/10.1016\/j.ajog.2026.09.044","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Survival outcomes of ovarian-sparing surgery for early-stage adult granulosa cell tumor","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajog.2026.09.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}