{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:40:15Z","timestamp":1788910815301,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T00:00:00Z","timestamp":1595030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ajogmfm.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.ajogmf.2020.100184","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T12:15:11Z","timestamp":1595333711000},"page":"100184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Low-dose aspirin for preeclampsia prevention: efficacy by ethnicity and race"],"prefix":"10.1016","volume":"2","author":[{"given":"Mary Catherine","family":"Tolcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleh","family":"Sangi-Haghpeykar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Mendez-Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjersti M.","family":"Aagaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajogmf.2020.100184_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.earlhumdev.2016.09.007","article-title":"Preeclampsia; short and long-term consequences for mother and neonate","volume":"102","author":"Bokslag","year":"2016","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ajogmf.2020.100184_bib2","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1097\/AOG.0000000000002708","article-title":"ACOG Committee Opinion no. 743: low-dose aspirin use during pregnancy","volume":"132","year":"2018","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.7326\/M14-1884","article-title":"Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement","volume":"161","author":"LeFevre","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajogmf.2020.100184_bib5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7326\/M13-2844","article-title":"Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force","volume":"160","author":"Henderson","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajogmf.2020.100184_bib6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/jch.12541","article-title":"Low-dose aspirin for preventing preeclampsia and its complications: a meta-analysis","volume":"17","author":"Xu","year":"2015","journal-title":"J\u00a0Clin Hypertens (Greenwich)"},{"key":"10.1016\/j.ajogmf.2020.100184_bib7","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data","volume":"369","author":"Askie","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ajogmf.2020.100184_bib8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM199803123381101","article-title":"Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units","volume":"338","author":"Caritis","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajogmf.2020.100184_bib9","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1056\/NEJM199310213291701","article-title":"Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units","volume":"329","author":"Sibai","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajogmf.2020.100184_bib10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0140-6736(94)92633-6","article-title":"CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group","volume":"343","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ajogmf.2020.100184_bib11","doi-asserted-by":"crossref","first-page":"365.e1","DOI":"10.1016\/j.ajog.2017.04.035","article-title":"Impact of USPSTF recommendations for aspirin for prevention of recurrent preeclampsia","volume":"217","author":"Tolcher","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1365-2125.2008.03183.x","article-title":"Pharmacogenetics of aspirin resistance: a comprehensive systematic review","volume":"66","author":"Goodman","year":"2008","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib13","first-page":"974","article-title":"Genetic signatures in ischemic stroke: focus on aspirin resistance","volume":"16","author":"Vasudeva","year":"2017","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.ajogmf.2020.100184_bib14","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.2174\/138161212803251907","article-title":"Pharmacogenetics of the antiplatelet effect of aspirin","volume":"18","author":"W\u00fcrtz","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ajogmf.2020.100184_bib15","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/jth.12318","article-title":"Pharmacogenomics in cardiovascular disease: focus on aspirin and ADP receptor antagonists","volume":"11","author":"W\u00fcrtz","year":"2013","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.ajogmf.2020.100184_bib16","doi-asserted-by":"crossref","first-page":"e78093","DOI":"10.1371\/journal.pone.0078093","article-title":"The association of four common polymorphisms from four candidate genes (COX-1, COX-2, ITGA2B, ITGA2) with aspirin insensitivity: a meta-analysis","volume":"8","author":"Weng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajogmf.2020.100184_bib17","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0140-6736(06)68040-9","article-title":"Aspirin resistance","volume":"367","author":"Hankey","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ajogmf.2020.100184_bib18","doi-asserted-by":"crossref","first-page":"e84244","DOI":"10.1371\/journal.pone.0084244","article-title":"Novel single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding","volume":"8","author":"Shiotani","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajogmf.2020.100184_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2217\/pgs.10.65","article-title":"Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics","volume":"11","author":"Kim","year":"2010","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.ajogmf.2020.100184_bib20","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2174\/138920009790711814","article-title":"Pharmacogenomics in aspirin intolerance","volume":"10","author":"Ag\u00fandez","year":"2009","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.ajogmf.2020.100184_bib21","doi-asserted-by":"crossref","first-page":"585.e1","DOI":"10.1016\/j.ajog.2017.07.038","article-title":"Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and medical and obstetrical history","volume":"217","author":"Poon","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib22","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/bcp.12335","article-title":"Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects","volume":"78","author":"Floyd","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pharmthera.2013.08.005","article-title":"Mechanisms of aspirin resistance","volume":"141","author":"Floyd","year":"2014","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.ajogmf.2020.100184_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/bmj.39430.529549.BE","article-title":"Aspirin \u201dresistance\u201d and risk of cardiovascular morbidity: systematic review and meta-analysis","volume":"336","author":"Krasopoulos","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.ajogmf.2020.100184_bib25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1159\/000214223","article-title":"Influence of cyclooxygenase-1 genotype on ex\u00a0vivo aspirin response in patients at risk for stroke","volume":"27","author":"Momary","year":"2009","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.ajogmf.2020.100184_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pharmthera.2011.01.011","article-title":"Aspirin resistance: effect of clinical, biochemical and genetic factors","volume":"130","author":"Fitzgerald","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.ajogmf.2020.100184_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.iac.2012.10.003","article-title":"Genetics of hypersensitivity to aspirin and nonsteroidal anti-inflammatory drugs","volume":"33","author":"Kim","year":"2013","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.ajogmf.2020.100184_bib28","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.2174\/1381612821666150915105537","article-title":"Low-dose aspirin-associated upper and mid gastrointestinal tract damage and gene polymorphism","volume":"21","author":"Shiotani","year":"2015","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ajogmf.2020.100184_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.12.004","article-title":"Predictors of biochemical aspirin and clopidogrel resistance in patients with ischemic stroke","volume":"20","author":"Fong","year":"2011","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.ajogmf.2020.100184_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2020.03.004","article-title":"Impact of the ACOG guideline regarding low-dose aspirin for prevention of superimposed preeclampsia in women with chronic hypertension","author":"Banala","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejogrb.2017.12.052","article-title":"Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia","volume":"221","author":"Navaratnam","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajog.2016.09.076","article-title":"The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis","volume":"216","author":"Roberge","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib33","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia","volume":"377","author":"Rolnik","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ajogmf.2020.100184_bib34","doi-asserted-by":"crossref","first-page":"685.e1","DOI":"10.1016\/j.ajog.2017.08.110","article-title":"Aspirin for Evidence-Based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia","volume":"217","author":"Wright","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ajog.2016.10.016","article-title":"Antiplatelet therapy before or after 16 weeks\u2019 gestation for preventing preeclampsia: an individual participant data meta-analysis","volume":"216","author":"Meher","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"2 Pt 1","key":"10.1016\/j.ajogmf.2020.100184_bib36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ajog.2018.03.018","article-title":"Optimal aspirin dosing for preeclampsia prevention","volume":"219","author":"Seidler","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100184_bib38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajog.2017.11.561","article-title":"Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis","volume":"218","author":"Roberge","year":"2018","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933320301282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933320301282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:47:49Z","timestamp":1762904869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589933320301282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2589933320301282"],"URL":"https:\/\/doi.org\/10.1016\/j.ajogmf.2020.100184","relation":{},"ISSN":["2589-9333"],"issn-type":[{"value":"2589-9333","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-dose aspirin for preeclampsia prevention: efficacy by ethnicity and race","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics & Gynecology MFM","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajogmf.2020.100184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100184"}}