{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:58:45Z","timestamp":1785304725183,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010377","name":"National Institute for Health and Care Excellence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajogmfm.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.ajogmf.2020.100220","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T12:40:16Z","timestamp":1599050416000},"page":"100220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cervical priming before surgical abortion up to 13+6 weeks\u2019 gestation: a systematic review and metaanalyses for the National Institute for Health and Care Excellence\u2014new clinical guidelines for England"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-6914","authenticated-orcid":false,"given":"Laura E.","family":"O\u2019Shea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Hasler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajogmf.2020.100220_bib1","series-title":"Safe abortion: technical and policy guidance for health systems","year":"2012"},{"key":"10.1016\/j.ajogmf.2020.100220_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.contraception.2007.05.001","article-title":"Cervical dilation before first-trimester surgical abortion (<14 weeks\u2019 gestation). SFP Guideline 20071","volume":"76","author":"Allen","year":"2007","journal-title":"Contraception"},{"key":"10.1016\/j.ajogmf.2020.100220_bib4","series-title":"The care of women requesting induced abortion (Evidence-based Clinical Guideline No.7)","year":"2000"},{"key":"10.1016\/j.ajogmf.2020.100220_bib6","series-title":"Cochrane handbook for systematic reviews of interventions version 5.1.0","year":"2011"},{"key":"10.1016\/j.ajogmf.2020.100220_bib7","series-title":"Review Manager. Version 5.3. Cochrane Training","year":"2014"},{"key":"10.1016\/j.ajogmf.2020.100220_bib8","author":"Deeks"},{"key":"10.1016\/j.ajogmf.2020.100220_bib9","series-title":"GRADEpro Guideline Development Tool","year":"2015"},{"key":"10.1016\/j.ajogmf.2020.100220_bib10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/01.MLR.0000062554.74615.4C","article-title":"Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation","volume":"41","author":"Norman","year":"2003","journal-title":"Med Care"},{"key":"10.1016\/j.ajogmf.2020.100220_bib11","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.jclinepi.2011.01.012","article-title":"GRADE guidelines 6. Rating the quality of evidence\u2014imprecision","volume":"64","author":"Guyatt","year":"2011","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.ajogmf.2020.100220_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.contraception.2004.11.009","article-title":"Comparison of oral and vaginal misoprostol for cervical ripening before manual vacuum aspiration of first trimester pregnancy under local anesthesia: a randomized placebo-controlled study","volume":"71","author":"Cakir","year":"2005","journal-title":"Contraception"},{"issue":"152","key":"10.1016\/j.ajogmf.2020.100220_bib13","first-page":"26","article-title":"Sublingual misoprostol prior to manual vacuum aspiration for reducing blood loss at 8-12 weeks of gestation: a randomized double-blind placebo-controlled study","author":"Chitaishvili","year":"2007","journal-title":"Georgian Med News"},{"key":"10.1016\/j.ajogmf.2020.100220_bib14","first-page":"256","article-title":"Randomised controlled trial of the efficacy of misoprostol used as a cervical ripening agent prior to termination of pregnancy in the first trimester","volume":"90","author":"de Jonge","year":"2000","journal-title":"S\u00a0Afr Med J"},{"key":"10.1016\/j.ajogmf.2020.100220_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/ejc.8.4.197.202","article-title":"The effect of oral versus vaginal misoprostol on cervical dilatation in first-trimester abortion: a double-blind, randomized study","volume":"8","author":"Inal","year":"2003","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.ajogmf.2020.100220_bib16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00006250-200309000-00028","article-title":"A\u00a0comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation","volume":"102","author":"Li","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100220_bib17","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/S0140-6736(11)61937-5","article-title":"WHO Research Group on Postovulatory Methods of Fertility Regulation. Complications of first-trimester abortion by vacuum aspiration after cervical preparation with and without misoprostol: a multicentre randomised trial","volume":"379","author":"Meirik","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ajogmf.2020.100220_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0010-7824(02)00517-6","article-title":"Role of sublingual misoprostol for cervical ripening prior to vacuum aspiration in first trimester interruption of pregnancy","volume":"67","author":"Saxena","year":"2003","journal-title":"Contraception"},{"key":"10.1016\/j.ajogmf.2020.100220_bib19","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1471-0528.2005.00255.x","article-title":"Oral versus vaginal misoprostol administered one hour before surgical termination of pregnancy: a randomized controlled trial","volume":"112","author":"Sharma","year":"2005","journal-title":"BJOG"},{"key":"10.1016\/j.ajogmf.2020.100220_bib20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s13224-011-0082-z","article-title":"Sublingual misoprostol for cervical priming in surgical first trimester pregnancy termination","volume":"61","author":"Sharma","year":"2011","journal-title":"J\u00a0Obstet Gynaecol India"},{"key":"10.1016\/j.ajogmf.2020.100220_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0010-7824(03)00024-6","article-title":"Sublingual misoprostol for preabortion cervical ripening in first-trimester pregnancy termination","volume":"67","author":"Vimala","year":"2003","journal-title":"Contraception"},{"key":"10.1016\/j.ajogmf.2020.100220_bib22","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1067\/mob.2000.106767","article-title":"Mifepristone versus vaginally administered misoprostol for cervical priming before first-trimester termination of pregnancy: a randomized, controlled study","volume":"183","author":"Ashok","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2020.100220_bib23","first-page":"54","article-title":"Sublingual misoprostol before first trimester abortion: a comparative study using two dose regimens","volume":"58","author":"Vimala","year":"2004","journal-title":"Indian J Med Sci"},{"key":"10.1016\/j.ajogmf.2020.100220_bib24","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/humrep\/dev071","article-title":"Sublingual versus vaginal misoprostol for cervical dilatation 1 or 3 h prior to surgical abortion: a double-blinded RCT","volume":"30","author":"S\u00e4\u00e4v","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajogmf.2020.100220_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejogrb.2005.07.022","article-title":"Sublingual versus vaginal route of misoprostol for cervical ripening prior to surgical termination of first trimester abortions","volume":"125","author":"Saxena","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ajogmf.2020.100220_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1479-828X.2007.00809.x","article-title":"A\u00a0randomized comparison between sublingual, oral and vaginal route of misoprostol for pre-abortion cervical ripening in first-trimester pregnancy termination under local anaesthesia","volume":"48","author":"Saxena","year":"2008","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ajogmf.2020.100220_bib27","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.contraception.2006.03.031","article-title":"Sublingual versus vaginal misoprostol (400 microg) for cervical priming in first-trimester abortion: a randomized trial","volume":"74","author":"Carbonell Esteve","year":"2006","journal-title":"Contraception"},{"key":"10.1016\/j.ajogmf.2020.100220_bib28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/humrep\/deh143","article-title":"A\u00a0randomized study comparing the use of sublingual to vaginal misoprostol for pre-operative cervical priming prior to surgical termination of pregnancy in the first trimester","volume":"19","author":"Tang","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajogmf.2020.100220_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.contraception.2004.02.017","article-title":"A\u00a0randomized comparison of sublingual and vaginal misoprostol for cervical priming before suction termination of first-trimester pregnancy","volume":"70","author":"Vimala","year":"2004","journal-title":"Contraception"},{"issue":"2","key":"10.1016\/j.ajogmf.2020.100220_bib30","first-page":"CD007207","article-title":"Cervical preparation for first trimester surgical abortion","author":"Kapp","year":"2010","journal-title":"Cochrane Database Syst Rev"}],"container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933320301889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933320301889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:46:50Z","timestamp":1762904810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589933320301889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2589933320301889"],"URL":"https:\/\/doi.org\/10.1016\/j.ajogmf.2020.100220","relation":{},"ISSN":["2589-9333"],"issn-type":[{"value":"2589-9333","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cervical priming before surgical abortion up to 13+6 weeks\u2019 gestation: a systematic review and metaanalyses for the National Institute for Health and Care Excellence\u2014new clinical guidelines for England","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics & Gynecology MFM","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajogmf.2020.100220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100220"}}