{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:00:30Z","timestamp":1794002430111,"version":"4.8.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajogmfm.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.ajogmf.2021.100393","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T12:57:40Z","timestamp":1620824260000},"page":"100393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Metabolites from midtrimester plasma of pregnant patients at high risk for preterm birth"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-6747","authenticated-orcid":false,"given":"Tracy A.","family":"Manuck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjia","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica V.","family":"Glover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Rager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl1","key":"10.1016\/j.ajogmf.2021.100393_bib0001","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1742-4755-10-S1-S2","article-title":"Born too soon: the global epidemiology of 15 million preterm births","volume":"10","author":"Blencowe","year":"2013","journal-title":"Reprod Health"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0002","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/01.AOG.0000267498.95402.bd","article-title":"Neonatal and 5-year outcomes after birth at 30-34 weeks of gestation","volume":"110","author":"Marret","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0003","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1001\/jama.288.6.728","article-title":"Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis","volume":"288","author":"Bhutta","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0004","doi-asserted-by":"crossref","first-page":"F70","DOI":"10.1136\/archdischild-2013-303788","article-title":"Very preterm\/very low birthweight infants\u2019 attachment: infant and maternal characteristics","volume":"99","author":"Wolke","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"Suppl2","key":"10.1016\/j.ajogmf.2021.100393_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/14767050902860690","article-title":"The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth","volume":"22","author":"Gotsch","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0006","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ajog.2011.10.864","article-title":"Challenges in defining and classifying the preterm birth syndrome","volume":"206","author":"Kramer","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0007","first-page":"433","article-title":"Ethnic and racial disparities in the risk of preterm birth: a systematic review and meta-analysis","volume":"30","author":"Schaaf","year":"2013","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0008","first-page":"1","article-title":"Births: final data for 2015","volume":"66","author":"Martin","year":"2017","journal-title":"Natl Vital Stat Rep"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0009","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1289\/ehp.10958","article-title":"Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction","volume":"116","author":"Choi","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0010","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.envres.2018.12.031","article-title":"Prenatal exposure to air pollution, maternal diabetes and preterm birth","volume":"170","author":"Padula","year":"2019","journal-title":"Environ Res"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0011","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1476-069X-10-89","article-title":"Traffic-related air toxics and preterm birth: a population-based case-control study in los Angeles County, California","volume":"10","author":"Wilhelm","year":"2011","journal-title":"Environ Health"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0012","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4103\/0971-5916.191922","article-title":"Organochlorine pesticides exposure & preterm birth","volume":"143","author":"Porpora","year":"2016","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0013","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4103\/0971-5916.191986","article-title":"Association of organochlorine pesticides with the mRNA expression of tumour necrosis factor-alpha (TNF-\u03b1) & cyclooxygenase-2 (COX-2) genes in idiopathic preterm birth","volume":"143","author":"Tyagi","year":"2016","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0014","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/toxics6030041","article-title":"Prenatal exposure to ambient pesticides and preterm birth and term low birthweight in agricultural regions of California","volume":"6","author":"Ling","year":"2018","journal-title":"Toxics"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0015","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3390\/ijerph14111339","article-title":"Prenatal heavy metal exposure and adverse birth outcomes in Myanmar: a birth-cohort study","volume":"14","author":"Wai","year":"2017","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0016","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.envint.2016.06.003","article-title":"Maternal urinary cadmium concentrations in relation to preterm birth in the Healthy Baby Cohort Study in China","volume":"94","author":"Yang","year":"2016","journal-title":"Environ Int"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0017","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.envint.2018.09.052","article-title":"Urinary trace metals individually and in mixtures in association with preterm birth","volume":"121","author":"Kim","year":"2018","journal-title":"Environ Int"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0018","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.3390\/ijerph15091832","article-title":"Prenatal exposure to perfluoroalkyl substances and birth outcomes; an updated analysis from the Danish National birth cohort","volume":"15","author":"Meng","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0019","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/aje\/kwx332","article-title":"Early-pregnancy plasma concentrations of perfluoroalkyl substances and birth outcomes in project viva: confounded by pregnancy hemodynamics?","volume":"187","author":"Sagiv","year":"2018","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0020","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1161\/CIRCULATIONAHA.105.569137","article-title":"Metabolomic identification of novel biomarkers of myocardial ischemia","volume":"112","author":"Sabatine","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0021","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1093\/eurheartj\/ehz235","article-title":"Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease","volume":"40","author":"Tzoulaki","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0022","article-title":"Women with preterm birth have a distinct cervicovaginal metabolome","volume":"212","author":"Ghartey","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0023","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1055\/s-0037-1603817","article-title":"Women with symptomatic preterm birth have a distinct cervicovaginal metabolome","volume":"34","author":"Ghartey","year":"2017","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0024","doi-asserted-by":"crossref","first-page":"27741","DOI":"10.3390\/ijms161126052","article-title":"Metabolite profile of cervicovaginal fluids from early pregnancy is not predictive of spontaneous preterm birth","volume":"16","author":"Thomas","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164211","article-title":"Untargeted metabolomic analysis of amniotic fluid in the prediction of preterm delivery and bronchopulmonary dysplasia","volume":"11","author":"Baraldi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0026","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1177\/1933719113518987","article-title":"Amniotic fluid metabolomic analysis in spontaneous preterm birth","volume":"21","author":"Menon","year":"2014","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0027","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1021\/acs.jproteome.6b00845","article-title":"Amniotic fluid and maternal serum metabolic signatures in the second trimester associated with preterm delivery","volume":"16","author":"Virgiliou","year":"2017","journal-title":"J Proteome Res"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2015.11.029","article-title":"Gestational dating by metabolic profile at birth: a California cohort study","volume":"214","author":"Jelliffe-Pawlowski","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0029","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/01.AOG.0000454932.15177.be","article-title":"Committee opinion no 611: method for estimating due date","volume":"124","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research Electronic Data Capture (REDCap)\u2013a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0031","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1002\/cpbi.86","article-title":"Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis","volume":"68","author":"Chong","year":"2019","journal-title":"Curr Protocols Bioinformatics"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0032","first-page":"18","article-title":"Classification and Regression by random Forest","volume":"2","author":"Liaw","year":"2002","journal-title":"R News"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0033","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2105-13-99","article-title":"MetaMapp: mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity","volume":"13","author":"Barupal","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0034","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1592\/phco.21.5.405.34503","article-title":"Post hoc power analysis: an idea whose time has passed?","volume":"21","author":"Levine","year":"2001","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0035","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/720514","article-title":"Metabolomics application in maternal-fetal medicine","volume":"2013","author":"Fanos","year":"2013","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0036","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3109\/14767058.2010.482618","article-title":"Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery","volume":"23","author":"Romero","year":"2010","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0037","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/metabo9050090","article-title":"Screening for preterm birth: potential for a metabolomics biomarker panel","volume":"9","author":"Considine","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0038","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9362820","article-title":"Maternal plasma metabolomic profiles in spontaneous preterm birth: preliminary results","volume":"2018","author":"Lizewska","year":"2018","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0039","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1210\/jcem-58-4-629","article-title":"Daily hormonal changes in the maternal, fetal, and amniotic fluid compartments before parturition in a primate species","volume":"58","author":"Walsh","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209579","article-title":"Maternal dyslipidemia and risk for preterm birth","volume":"13","author":"Smith","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0041","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tjog.2016.07.012","article-title":"Maternal dyslipidemia during pregnancy may increase the risk of preterm birth: a meta-analysis","volume":"56","author":"Jiang","year":"2017","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0042","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/nu8050313","article-title":"The role of avocados in maternal diets during the periconceptional period, pregnancy, and lactation","volume":"8","author":"Comerford","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0043","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.biopha.2016.10.049","article-title":"Diosgenin ameliorates gestational diabetes through inhibition of sterol regulatory element-binding protein-1","volume":"84","author":"Hua","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0044","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3390\/nu8060351","article-title":"Maternal dietary patterns and pregnancy outcome","volume":"8","author":"Chen","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0045","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.3945\/jn.115.212019","article-title":"Maternal dietary patterns during the second trimester are associated with preterm birth","volume":"145","author":"Martin","year":"2015","journal-title":"J Nutr"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0046","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/152873901753246205","article-title":"Associations of polycyclic organic matter in outdoor air with decreased birth weight: a pilot cross-sectional analysis","volume":"64","author":"Vassilev","year":"2001","journal-title":"J Toxicol Environ Health A"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0047","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/papr.12814","article-title":"Medication use and pain management in pregnancy: a critical review","volume":"19","author":"Black","year":"2019","journal-title":"Pain Pract"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0048","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/s41390-019-0726-8","article-title":"Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort","volume":"87","author":"Arneja","year":"2020","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajogmf.2021.100393_bib0049","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3109\/14767050903334877","article-title":"Use of acetaminophen during pregnancy and risk of preeclampsia, hypertensive and vascular disorders: a birth cohort study","volume":"23","author":"Rebordosa","year":"2010","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933321000884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933321000884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:48:24Z","timestamp":1762904904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589933321000884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S2589933321000884"],"URL":"https:\/\/doi.org\/10.1016\/j.ajogmf.2021.100393","relation":{},"ISSN":["2589-9333"],"issn-type":[{"value":"2589-9333","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolites from midtrimester plasma of pregnant patients at high risk for preterm birth","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics & Gynecology MFM","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajogmf.2021.100393","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100393"}}