{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:24:01Z","timestamp":1790115841588,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD000849"],"award-info":[{"award-number":["HD000849"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 ES022242"],"award-info":[{"award-number":["K23 ES022242"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002541"],"award-info":[{"award-number":["UL1 TR002541"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001680","name":"Charles H. Hood Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajogmfm.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics & Gynecology MFM"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ajogmf.2022.100783","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:01:18Z","timestamp":1666396878000},"page":"100783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cervical microRNA expression and spontaneous preterm birth"],"prefix":"10.1016","volume":"5","author":[{"given":"Heather H.","family":"Burris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin D.","family":"Gerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson M.","family":"Redhunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Ledyard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasey","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Baccarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Hecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Ris Y.","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele R.","family":"Hacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajogmf.2022.100783_bib0001","unstructured":"World Health Organization. Preterm birth. 2018. Available at: https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/preterm-birth. Accessed February 3, 2021."},{"key":"10.1016\/j.ajogmf.2022.100783_bib0002","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jamapediatrics.2018.1792","article-title":"Association between temporal changes in neonatal mortality and spontaneous and clinician-initiated deliveries in the United States, 2006-2013","volume":"172","author":"Ananth","year":"2018","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0003","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2016.04.027","article-title":"The role of routine cervical length screening in selected high- and low-risk women for preterm birth prevention","volume":"215","author":"McIntosh","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0004","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.siny.2015.12.009","article-title":"Cervical etiology of spontaneous preterm birth","volume":"21","author":"Vink","year":"2016","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0005","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0006","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0007","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0008","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/15592294.2015.1006498","article-title":"microRNA expression in the cervix during pregnancy is associated with length of gestation","volume":"10","author":"Sanders","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0009","first-page":"221","article-title":"Distinct cervical microRNA profiles are present in women destined to have a preterm birth","volume":"210","author":"Elovitz","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0010","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1097\/AOG.0000000000004447","article-title":"American College of Obstetricians and Gynecologists\u2019 Committee on Obstetric Practice, Society for Maternal-Fetal Medicine. Medically indicated late-preterm and early-term deliveries: ACOG Committee Opinion","volume":"138","year":"2021","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0011","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.2217\/epi-2019-0231","article-title":"Pregnancy-associated changes in cervical noncoding RNA","volume":"12","author":"Gerson","year":"2020","journal-title":"Epigenomics"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0012","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2217\/epi.15.54","article-title":"Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure","volume":"7","author":"Sanders","year":"2015","journal-title":"Epigenomics"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0013","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2217\/epi-2016-0095","article-title":"Bacterial and cytokine mixtures predict the length of gestation and are associated with miRNA expression in the cervix","volume":"9","author":"Sanders","year":"2017","journal-title":"Epigenomics"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0014","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jbi.2018.07.015","article-title":"Benchmarking relief-based feature selection methods for bioinformatics data mining","volume":"85","author":"Urbanowicz","year":"2018","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jbi.2018.07.014","article-title":"Relief-based feature selection: introduction and review","volume":"85","author":"Urbanowicz","year":"2018","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0016","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw345","article-title":"miEAA: microRNA enrichment analysis and annotation","volume":"44","author":"Backes","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0017","doi-asserted-by":"crossref","first-page":"W521","DOI":"10.1093\/nar\/gkaa309","article-title":"miEAA 2.0: integrating multi-species microRNA enrichment analysis and workflow management systems","volume":"48","author":"Kern","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0018","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191524","article-title":"Colonization of the cervicovaginal space with vaginalis leads to local inflammation and cervical remodeling in pregnant mice","volume":"13","author":"Sierra","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0020","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13059-022-02635-9","article-title":"Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data","volume":"23","author":"France","year":"2022","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0021","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2049-2618-1-12","article-title":"Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis","volume":"1","author":"Macklaim","year":"2013","journal-title":"Microbiome"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0022","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphys.2015.00151","article-title":"Human cervicovaginal fluid biomarkers to predict term and preterm labor","volume":"6","author":"Heng","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0023","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ajog.2019.11.1252","article-title":"Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth","volume":"222","author":"Parry","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0024","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1126\/science.aaa1738","article-title":"Gene expression. MicroRNA control of protein expression noise","volume":"348","author":"Schmiedel","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0025","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1038\/ncomms3364","article-title":"MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise","volume":"4","author":"Siciliano","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0026","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0027","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/ncb2441","article-title":"Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs","volume":"14","author":"Hergenreider","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0028","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-derived circulating miRNAs regulate gene expression in other tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0029","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1158\/1078-0432.CCR-13-2500","article-title":"Molecular pathways: microRNAs, cancer cells, and microenvironment","volume":"20","author":"Berindan-Neagoe","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0030","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrm2868","article-title":"MicroRNA control of signal transduction","volume":"11","author":"Inui","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0031","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2014.06.005","article-title":"MicroRNAs in cancer: biomarkers, functions and therapy","volume":"20","author":"Hayes","year":"2014","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0032","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jcp.25056","article-title":"MicroRNA as biomarkers and diagnostics","volume":"231","author":"Wang","year":"2016","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0033","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4939-7046-9_4","article-title":"MicroRNAs: biomarkers, diagnostics, and therapeutics","volume":"1617","author":"Huang","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0034","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1158\/0008-5472.CAN-06-1894","article-title":"MicroRNA responses to cellular stress","volume":"66","author":"Marsit","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0035","doi-asserted-by":"crossref","first-page":"e6045","DOI":"10.1371\/journal.pone.0006045","article-title":"Increased microRNA activity in human cancers","volume":"4","author":"Israel","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0036","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1111\/febs.14482","article-title":"A guide to miRNAs in inflammation and innate immune responses","volume":"285","author":"Nejad","year":"2018","journal-title":"FEBS Journal"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0037","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1055\/s-0040-1718575","article-title":"Inflammatory proteins in the amniotic fluid, plasma, and cervicovaginal fluid for the prediction of intra-amniotic infection\/inflammation and imminent preterm birth in preterm labor","volume":"39","author":"Kim","year":"2022","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0038","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1530\/REP-12-0264","article-title":"Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes","volume":"145","author":"Liong","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0039","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ppe.12087","article-title":"Predicting risk of spontaneous preterm delivery in women with a singleton pregnancy","volume":"28","author":"Morken","year":"2014","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13040-022-00289-8","article-title":"PredictPTB: an interpretable preterm birth prediction model using attention-based recurrent neural networks","volume":"15","author":"AlSaad","year":"2022","journal-title":"BioData Min"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0041","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1038\/s41598-017-03217-7","article-title":"miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation","volume":"7","author":"Anton","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.anaerobe.2019.102127","article-title":"Microbial supernatants from Mobiluncus mulieris, a bacteria strongly associated with spontaneous preterm birth, disrupts the cervical epithelial barrier through inflammatory and miRNA mediated mechanisms","volume":"61","author":"Dude","year":"2020","journal-title":"Anaerobe"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0043","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1109\/34.709601","article-title":"The random subspace method for constructing decision forests","volume":"20","author":"Ho","year":"1998","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"10.1016\/j.ajogmf.2022.100783_bib0044","series-title":"at: Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining","article-title":"XGBoost: A scalable tree boosting system","author":"Chen","year":"2016"}],"container-title":["American Journal of Obstetrics & Gynecology MFM"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933322002130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933322002130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:50:56Z","timestamp":1762905056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589933322002130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2589933322002130"],"URL":"https:\/\/doi.org\/10.1016\/j.ajogmf.2022.100783","relation":{},"ISSN":["2589-9333"],"issn-type":[{"value":"2589-9333","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cervical microRNA expression and spontaneous preterm birth","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics & Gynecology MFM","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajogmf.2022.100783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100783"}}